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Asymptomatic abdominal aortic aneurysms show histological signs of progression: a quantitative histochemical analysis
L. Eberlová, Z. Tonar, K. Witter, V. Křížková, L. Nedorost, M. Korabečná, P. Tolinger, J. Kočová, L. Boudová, V. Třeška, K. Houdek, J. Moláček, J. Vrzalová, M. Pešta, O. Topolčan, J. Valenta,
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, práce podpořená grantem
Nursing & Allied Health Database (ProQuest) od 1995-05-01 do 2015-11-30
Health & Medicine (ProQuest) od 1995-05-01 do Před 1 rokem
Public Health Database (ProQuest) od 1995-05-01 do 2015-11-30
Odkazy
PubMed
22797551
DOI
10.1159/000339304
Knihovny.cz E-zdroje
- MeSH
- aktiny metabolismus MeSH
- aneurysma břišní aorty metabolismus patologie MeSH
- aorta abdominalis metabolismus patologie MeSH
- asymptomatické nemoci MeSH
- cévní buněčněadhezivní molekula-1 metabolismus MeSH
- desmin metabolismus MeSH
- dospělí MeSH
- elastin metabolismus MeSH
- extracelulární matrix metabolismus MeSH
- histocytochemie MeSH
- inhibitor aktivátoru plazminogenu 1 metabolismus MeSH
- kolagen metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- matrixová metaloproteinasa 2 metabolismus MeSH
- progrese nemoci MeSH
- prospektivní studie MeSH
- ruptura aorty metabolismus patologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- trombóza metabolismus patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
OBJECTIVE: Abdominal aortic aneurysm (AAA) is a serious disease due to its covert nature, relatively high prevalence and fatal prognosis in the case of rupture. To obtain new insights into AAA pathogenesis, we examined the relationships between histopathology, multiplex in vitro immunoassay data, diameter and symptomatology. METHODS: In a prospective, non-randomised study, we evaluated samples from 6 normal infrarenal aortae and 65 AAA patients (65 walls, 55 thrombi). The AAA patients were either asymptomatic (n = 44), symptomatic (n = 7) or with ruptured AAA (n = 14). The AAA diameter was classified as small (<5 cm, n = 18), medium (5-7 cm, n = 26) and large (>7 cm, n = 21). We quantified the histopathology of the AAA wall and the adjacent thrombus. We assessed the expression of proteins in the same samples. RESULTS: Asymptomatic AAAs had walls with more abundant inflammatory infiltrates, lower amounts of PAI-1, a higher number of tPA-positive elements, a tendency towards decreased collagen content, whereas the adjacent thrombi had a greater concentration of VCAM-1 and MMP-2 when compared with symptomatic AAAs. Compared with the aneurysmatic aorta, the normal aorta contained less collagen and more elastin, actin, desmin and PAI-1-positive elements; in addition, it was more vascular. Medium-sized AAAs were the most actin and vimentin rich, and large AAAs were the most vascular. CONCLUSION: Our results show that asymptomatic AAA walls often have more potentially deleterious histopathological alterations than symptomatic AAA walls. This result indicates that a progression from an asymptomatic AAA to rupture can be expected and screening patients who are at risk of rupture could be beneficial.
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- $a Eberlová, Lada $u Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
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- $a Asymptomatic abdominal aortic aneurysms show histological signs of progression: a quantitative histochemical analysis / $c L. Eberlová, Z. Tonar, K. Witter, V. Křížková, L. Nedorost, M. Korabečná, P. Tolinger, J. Kočová, L. Boudová, V. Třeška, K. Houdek, J. Moláček, J. Vrzalová, M. Pešta, O. Topolčan, J. Valenta,
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- $a OBJECTIVE: Abdominal aortic aneurysm (AAA) is a serious disease due to its covert nature, relatively high prevalence and fatal prognosis in the case of rupture. To obtain new insights into AAA pathogenesis, we examined the relationships between histopathology, multiplex in vitro immunoassay data, diameter and symptomatology. METHODS: In a prospective, non-randomised study, we evaluated samples from 6 normal infrarenal aortae and 65 AAA patients (65 walls, 55 thrombi). The AAA patients were either asymptomatic (n = 44), symptomatic (n = 7) or with ruptured AAA (n = 14). The AAA diameter was classified as small (<5 cm, n = 18), medium (5-7 cm, n = 26) and large (>7 cm, n = 21). We quantified the histopathology of the AAA wall and the adjacent thrombus. We assessed the expression of proteins in the same samples. RESULTS: Asymptomatic AAAs had walls with more abundant inflammatory infiltrates, lower amounts of PAI-1, a higher number of tPA-positive elements, a tendency towards decreased collagen content, whereas the adjacent thrombi had a greater concentration of VCAM-1 and MMP-2 when compared with symptomatic AAAs. Compared with the aneurysmatic aorta, the normal aorta contained less collagen and more elastin, actin, desmin and PAI-1-positive elements; in addition, it was more vascular. Medium-sized AAAs were the most actin and vimentin rich, and large AAAs were the most vascular. CONCLUSION: Our results show that asymptomatic AAA walls often have more potentially deleterious histopathological alterations than symptomatic AAA walls. This result indicates that a progression from an asymptomatic AAA to rupture can be expected and screening patients who are at risk of rupture could be beneficial.
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