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Impact of psychotropic drugs on adult hippocampal neurogenesis
A. Kubesova, V. Bubenikova-Valesova, M. Mertlova, T. Palenicek, J. Horacek,
Jazyk angličtina Země Irsko
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
NS10378
MZ0
CEP - Centrální evidence projektů
- MeSH
- emoce účinky léků fyziologie MeSH
- hipokampus cytologie účinky léků fyziologie MeSH
- kognice účinky léků fyziologie MeSH
- lidé MeSH
- neurogeneze účinky léků fyziologie MeSH
- psychotropní léky farmakologie MeSH
- stárnutí účinky léků fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
This review focuses on the relationship between psychotropic drugs and adult hippocampal neurogenesis. Adult neurogenesis is important for learning and memory, as well as for depression and anxiety. There is some evidence that chronic treatment with opiates, stimulants and entactogens decreases neurogenesis and consequently impairs cognitive function, as well as inducing depressive-like behaviour in animals during drug withdrawal. On the other hand, NMDA receptor antagonists increase neurogenesis, but negatively affect cognitive function and have an antidepressant-like profile. We suggest that drug-induced changes in neurogenesis have a greater and more concise effect on emotive state reflecting the direction of influencing new cells proliferation than the performance of cognitive tasks. In this review we provide some evidence for this assumption.
Citace poskytuje Crossref.org
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- $a This review focuses on the relationship between psychotropic drugs and adult hippocampal neurogenesis. Adult neurogenesis is important for learning and memory, as well as for depression and anxiety. There is some evidence that chronic treatment with opiates, stimulants and entactogens decreases neurogenesis and consequently impairs cognitive function, as well as inducing depressive-like behaviour in animals during drug withdrawal. On the other hand, NMDA receptor antagonists increase neurogenesis, but negatively affect cognitive function and have an antidepressant-like profile. We suggest that drug-induced changes in neurogenesis have a greater and more concise effect on emotive state reflecting the direction of influencing new cells proliferation than the performance of cognitive tasks. In this review we provide some evidence for this assumption.
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