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Recent advances in the combination of capillary electrophoresis with mass spectrometry: from element to single-cell analysis

K. Klepárník,

. 2013 ; 34 (1) : 70-85.

Language English Country Germany

Document type Journal Article, Research Support, Non-U.S. Gov't, Review

Persistent link   https://www.medvik.cz/link/bmc13024143

This overview deals with the latest development of electrophoresis in capillaries and microfluidic devices coupled to MS detection. A wide selection of relevant articles covers the literature published from January 2010 till June 2012 as a continuation of the review article on the same topic by Pantuckova et al. [Electrophoresis 2011, 32, 43-51]. Special attention is paid to the new improvements in instrumentation and methodology of three interfacing methods, ESI, matrix-assisted desorption/ionization, and ICP. Representative examples illustrate applications in the proteomics, glycomics, metabolomics, biomarker research, forensics, pharmacology, food analysis and single-cell analysis. The combinations of MS with capillary versions of electrochromatography, ITP, IEF, and micellar electrokinetic chromatography are not included.

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