• Something wrong with this record ?

Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: metal-induced oligomerization of dota-bisphosphonate conjugates

V. Kubíček, T. Vitha, J. Kotek, P. Hermann, L. Vander Elst, R. N. Muller, I. Lukeš, J. A. Peters

. 2010 ; 5 (5) : 294-296.

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc12026696

In magnetic resonance imaging (MRI), paramagnetic complexes are utilized as contrast agents. Much attention has been paid to the development of new contrast agents responsive to pH, temperature or concentration of various components of body liquids. We report a new type of MRI probe sensing the concentrations of calcium and magnesium in biological media. The ligand do3ap(BP) combines a dota-like chelator with a bisphosphonate group. In the complex, the Gd(III) ion is entrapped in the macrocyclic cavity whereas the bisphosphonate group is not coordinated and therefore is available for coordination with endogenous metal ions. In the presence of metal ions, Gd-do3ap(BP) appears to show formation of coordination oligomers leading to an unprecedented increase in r(1) up to 200-500%. The extremely high relaxivity response makes this type of compound interesting for further studies as MRI ion-responsive probes for biomedical research.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12026696
003      
CZ-PrNML
005      
20160307111647.0
007      
ta
008      
120816s2010 xxu f 000 0#eng||
009      
AR
024    7_
$a 10.1002/cmmi.386 $2 doi
035    __
$a (PubMed)20973114
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Kubíček, Vojtěch, $d 1978- $7 uk2007350367 $u Department of Inorganic Chemistry, Faculty of Science, Charles University in Prague, Prague, Czech Republic. kubicek@natur.cuni.cz
245    10
$a Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: metal-induced oligomerization of dota-bisphosphonate conjugates / $c V. Kubíček, T. Vitha, J. Kotek, P. Hermann, L. Vander Elst, R. N. Muller, I. Lukeš, J. A. Peters
520    9_
$a In magnetic resonance imaging (MRI), paramagnetic complexes are utilized as contrast agents. Much attention has been paid to the development of new contrast agents responsive to pH, temperature or concentration of various components of body liquids. We report a new type of MRI probe sensing the concentrations of calcium and magnesium in biological media. The ligand do3ap(BP) combines a dota-like chelator with a bisphosphonate group. In the complex, the Gd(III) ion is entrapped in the macrocyclic cavity whereas the bisphosphonate group is not coordinated and therefore is available for coordination with endogenous metal ions. In the presence of metal ions, Gd-do3ap(BP) appears to show formation of coordination oligomers leading to an unprecedented increase in r(1) up to 200-500%. The extremely high relaxivity response makes this type of compound interesting for further studies as MRI ion-responsive probes for biomedical research.
650    _2
$a vápník $x chemie $7 D002118
650    _2
$a kontrastní látky $x chemie $7 D003287
650    _2
$a bisfosfonáty $x chemie $7 D004164
650    _2
$a gadolinium $x chemie $7 D005682
650    _2
$a hořčík $x chemie $7 D008274
650    _2
$a magnetická rezonanční tomografie $x metody $7 D008279
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Viťha, Tomáš $7 _AN061390 $u Department of Inorganic Chemistry, Faculty of Science, Charles University in Prague,Prague, Czech Republic
700    1_
$a Kotek, Jan, $d 1976- $7 jx20071212039 $u Department of Inorganic Chemistry, Faculty of Science, Charles University in Prague,Prague, Czech Republic
700    1_
$a Hermann, Petr, $d 1963- $7 uk2008403108 $u Department of Inorganic Chemistry, Faculty of Science, Charles University in Prague,Prague, Czech Republic
700    1_
$a Vander Elst, Luce $u Department of Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Mons, Belgium
700    1_
$a Muller, Robert N. $u Department of Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Mons, Belgium
700    1_
$a Lukeš, Ivan, $d 1947- $7 jn20000710422 $u Department of Inorganic Chemistry, Faculty of Science, Charles University in Prague,Prague, Czech Republic
700    1_
$a Peters, Joop A. $u Biocatalysis and Organic Chemistry, Department of Biotechnology, Delft University of Technology, Delft, The Netherlands
773    0_
$w MED00180205 $t Contrast media & molecular imaging $x 1555-4317 $g Roč. 5, č. 5 (2010), s. 294-296
856    41
$u https://pubmed.ncbi.nlm.nih.gov/20973114 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m $z 0
990    __
$a 20120816 $b ABA008
991    __
$a 20160307111704 $b ABA008
999    __
$a ok $b bmc $g 948738 $s 784042
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2010 $b 5 $c 5 $d 294-296 $i 1555-4317 $m Contrast Media Mol Imaging $n Contrast Media Mol Imaging $x MED00180205
LZP    __
$b NLK122 $a Pubmed-20120816/11/01

Find record

Citation metrics

Archiving options