Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: metal-induced oligomerization of dota-bisphosphonate conjugates
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20973114
DOI
10.1002/cmmi.386
Knihovny.cz E-resources
- MeSH
- Diphosphonates chemistry MeSH
- Gadolinium chemistry MeSH
- Magnesium chemistry MeSH
- Contrast Media chemistry MeSH
- Magnetic Resonance Imaging methods MeSH
- Calcium chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Diphosphonates MeSH
- Gadolinium MeSH
- Magnesium MeSH
- Contrast Media MeSH
- Calcium MeSH
In magnetic resonance imaging (MRI), paramagnetic complexes are utilized as contrast agents. Much attention has been paid to the development of new contrast agents responsive to pH, temperature or concentration of various components of body liquids. We report a new type of MRI probe sensing the concentrations of calcium and magnesium in biological media. The ligand do3ap(BP) combines a dota-like chelator with a bisphosphonate group. In the complex, the Gd(III) ion is entrapped in the macrocyclic cavity whereas the bisphosphonate group is not coordinated and therefore is available for coordination with endogenous metal ions. In the presence of metal ions, Gd-do3ap(BP) appears to show formation of coordination oligomers leading to an unprecedented increase in r(1) up to 200-500%. The extremely high relaxivity response makes this type of compound interesting for further studies as MRI ion-responsive probes for biomedical research.
Department of Inorganic Chemistry Faculty of Science Charles University Prague Prague Czech Republic
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