• Something wrong with this record ?

Short-term fasting reduces the extent of myocardial infarction and incidence of reperfusion arrhythmias in rats

M. Snorek, D. Hodyc, V. Sedivý, J. Durišová, A. Skoumalová, J. Wilhelm, J. Neckář, F. Kolář, J. Herget

. 2012 ; 61 (6) : 567-574.

Language English Country Czech Republic

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc13033352

The effect of three-day fasting on cardiac ischemic tolerance was investigated in adult male Wistar rats. Anesthetized open-chest animals (pentobarbitone 60 mg/kg, i.p.) were subjected to 20-min left anterior descending coronary artery occlusion and 3-h reperfusion for infarct size determination. Ventricular arrhythmias were monitored during ischemia and at the beginning (3 min) of reperfusion. Myocardial concentrations of beta-hydroxybutyrate and acetoacetate were measured to assess mitochondrial redox state. Short-term fasting limited the infarct size (48.5+/-3.3 % of the area at risk) compared to controls (74.3+/-2.2 %) and reduced the total number of premature ventricular complexes (12.5+/-5.8) compared to controls (194.9+/-21.9) as well as the duration of ventricular tachycardia (0.6+/-0.4 s vs. 18.8+/-2.5 s) occurring at early reperfusion. Additionally, fasting increased the concentration of beta-hydroxybutyrate and beta-hydroxybutyrate/acetoacetate ratio (87.8+/-27.0) compared to controls (7.9+/-1.7), reflecting altered mitochondrial redox state. It is concluded that three-day fasting effectively protected rat hearts against major endpoints of acute I/R injury. Further studies are needed to find out whether these beneficial effects can be linked to altered mitochondrial redox state resulting from increased ketogenesis.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc13033352
003      
CZ-PrNML
005      
20230522105130.0
007      
ta
008      
131015s2012 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.932338 $2 doi
035    __
$a (PubMed)23098657
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Šnorek, Michal $u Department of Physiology, Second Faculty of Medicine, Charles University in Prague, Prague; Department of the Medical Chemistry and Biochemistry, Second Faculty of Medicine, Charles University in Prague, Prague; Heart Center, České Budějovice Hospital, České Budějovice $7 xx0241468
245    10
$a Short-term fasting reduces the extent of myocardial infarction and incidence of reperfusion arrhythmias in rats / $c M. Snorek, D. Hodyc, V. Sedivý, J. Durišová, A. Skoumalová, J. Wilhelm, J. Neckář, F. Kolář, J. Herget
520    9_
$a The effect of three-day fasting on cardiac ischemic tolerance was investigated in adult male Wistar rats. Anesthetized open-chest animals (pentobarbitone 60 mg/kg, i.p.) were subjected to 20-min left anterior descending coronary artery occlusion and 3-h reperfusion for infarct size determination. Ventricular arrhythmias were monitored during ischemia and at the beginning (3 min) of reperfusion. Myocardial concentrations of beta-hydroxybutyrate and acetoacetate were measured to assess mitochondrial redox state. Short-term fasting limited the infarct size (48.5+/-3.3 % of the area at risk) compared to controls (74.3+/-2.2 %) and reduced the total number of premature ventricular complexes (12.5+/-5.8) compared to controls (194.9+/-21.9) as well as the duration of ventricular tachycardia (0.6+/-0.4 s vs. 18.8+/-2.5 s) occurring at early reperfusion. Additionally, fasting increased the concentration of beta-hydroxybutyrate and beta-hydroxybutyrate/acetoacetate ratio (87.8+/-27.0) compared to controls (7.9+/-1.7), reflecting altered mitochondrial redox state. It is concluded that three-day fasting effectively protected rat hearts against major endpoints of acute I/R injury. Further studies are needed to find out whether these beneficial effects can be linked to altered mitochondrial redox state resulting from increased ketogenesis.
650    _2
$a kyselina 3-hydroxymáselná $x metabolismus $x farmakologie $7 D020155
650    _2
$a acetoacetáty $x metabolismus $x farmakologie $7 D000090
650    _2
$a zvířata $7 D000818
650    _2
$a srdeční arytmie $x patofyziologie $x veterinární $7 D001145
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a mitochondrie $x metabolismus $7 D008928
650    _2
$a infarkt myokardu $x metabolismus $x veterinární $7 D009203
650    _2
$a reperfuzní poškození myokardu $x metabolismus $x veterinární $7 D015428
650    _2
$a oxidace-redukce $7 D010084
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani Wistar $7 D017208
650    _2
$a komorová tachykardie $x komplikace $7 D017180
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Hodyc, Daniel, $u Department of Physiology, Second Faculty of Medicine, Charles University in Prague, Prague; Centre for Cardiovascular Research, Prague $d 1979- $7 xx0074202
700    1_
$a Šedivý, Vojtěch. $u Department of Physiology, Second Faculty of Medicine, Charles University in Prague, Prague; Centre for Cardiovascular Research, Prague $7 xx0216304
700    1_
$a Ďurišová, Jana $u Centre for Cardiovascular Research, Prague $7 xx0301778
700    1_
$a Skoumalová, Alice, $u Department of the Medical Chemistry and Biochemistry, Second Faculty of Medicine, Charles University in Prague, Prague; Centre for Cardiovascular Research, Prague $d 1973- $7 xx0037063
700    1_
$a Wilhelm, Jiří, $u Department of the Medical Chemistry and Biochemistry, Second Faculty of Medicine, Charles University in Prague, Prague; Centre for Cardiovascular Research, Prague $d 1950- $7 nlk19990074059
700    1_
$a Neckář, Jan, $u Institute of Physiology, Academy of Sciences of the Czech Republic, Prague; Centre for Cardiovascular Research, Prague $d 1973- $7 xx0074182
700    1_
$a Kolář, František, $u Institute of Physiology, Academy of Sciences of the Czech Republic, Prague; Centre for Cardiovascular Research, Prague $d 1952 říjen 2.- $7 xx0037264
700    1_
$a Herget, Jan, $u Department of Physiology, Second Faculty of Medicine, Charles University in Prague, Prague; Centre for Cardiovascular Research, Prague $d 1945-2019 $7 nlk19990073223
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 61, č. 6 (2012), s. 567-574
856    41
$u http://www.biomed.cas.cz/physiolres/archive.htm $y domovská stránka časopisu - plný text volně přístupný = fulltext
910    __
$a ABA008 $b A 4120 $c 266 $y 3 $z 0
990    __
$a 20131015 $b ABA008
991    __
$a 20230522105128 $b ABA008
999    __
$a ok $b bmc $g 998658 $s 831806
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2012 $b 61 $c 6 $d 567-574 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK111 $a Pubmed-20131015

Find record

Citation metrics

Archiving options