Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation

Y. Nishiyama, T. Kataoka, J. Teraoka, A. Sakoda, H. Tanaka, Y. Ishimori, F. Mitsunobu, T. Taguchi, K. Yamaoka

. 2013 ; 62 (1) : 57-66.

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc13033360

We examined the protective effect of radon inhalation on streptozotocin (STZ)-induced type-1 diabetes in mice. Mice inhaled radon at concentrations of 1000, 2500, and 5500 Bq/m3 for 24 hours before STZ administration. STZ administration induced characteristics of type-1 diabetes such as hyperglycemia and hypoinsulinemia; however, radon inhalation at doses of 1000 and 5500 Bq/m3 significantly suppressed the elevation of blood glucose in diabetic mice. Serum insulin was significantly higher in mice pre-treated with radon at a dose of 1000 Bq/m3 than in mice treated with a sham. In addition, superoxide dismutase activities and total glutathione contents were significantly higher and lipid peroxide was significantly lower in mice pre-treated with radon at doses of 1000 and 5500 Bq/m3 than in mice treated with a sham. These results were consistent with the result that radon inhalation at 1000 and 5500 Bq/m3 suppressed hyperglycemia. These findings suggested that radon inhalation suppressed STZ-induced type-1 diabetes through the enhancement of antioxidative functions in the pancreas.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc13033360
003      
CZ-PrNML
005      
20150310093527.0
007      
ta
008      
131015s2013 xr da f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.932317 $2 doi
035    __
$a (PubMed)23173687
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Nishiyama, Y. $u Graduate School of Health Sciences, Okayama University, Okayama, Japan
245    10
$a Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation / $c Y. Nishiyama, T. Kataoka, J. Teraoka, A. Sakoda, H. Tanaka, Y. Ishimori, F. Mitsunobu, T. Taguchi, K. Yamaoka
520    9_
$a We examined the protective effect of radon inhalation on streptozotocin (STZ)-induced type-1 diabetes in mice. Mice inhaled radon at concentrations of 1000, 2500, and 5500 Bq/m3 for 24 hours before STZ administration. STZ administration induced characteristics of type-1 diabetes such as hyperglycemia and hypoinsulinemia; however, radon inhalation at doses of 1000 and 5500 Bq/m3 significantly suppressed the elevation of blood glucose in diabetic mice. Serum insulin was significantly higher in mice pre-treated with radon at a dose of 1000 Bq/m3 than in mice treated with a sham. In addition, superoxide dismutase activities and total glutathione contents were significantly higher and lipid peroxide was significantly lower in mice pre-treated with radon at doses of 1000 and 5500 Bq/m3 than in mice treated with a sham. These results were consistent with the result that radon inhalation at 1000 and 5500 Bq/m3 suppressed hyperglycemia. These findings suggested that radon inhalation suppressed STZ-induced type-1 diabetes through the enhancement of antioxidative functions in the pancreas.
650    _2
$a aplikace inhalační $7 D000280
650    _2
$a zvířata $7 D000818
650    _2
$a antioxidancia $x aplikace a dávkování $7 D000975
650    _2
$a biologické markery $x krev $7 D015415
650    _2
$a krevní glukóza $x účinky léků $x metabolismus $7 D001786
650    _2
$a tělesná hmotnost $x účinky léků $7 D001835
650    _2
$a experimentální diabetes mellitus $x krev $x chemicky indukované $x patologie $x prevence a kontrola $7 D003921
650    _2
$a diabetes mellitus 1. typu $x krev $x chemicky indukované $x patologie $x prevence a kontrola $7 D003922
650    _2
$a vztah mezi dávkou a účinkem léčiva $7 D004305
650    _2
$a plyny $7 D005740
650    _2
$a glutathion $x metabolismus $7 D005978
650    _2
$a hypoglykemika $x aplikace a dávkování $7 D007004
650    _2
$a inzulin $x krev $7 D007328
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a myši $7 D051379
650    _2
$a myši inbrední C57BL $7 D008810
650    _2
$a pankreas $x účinky léků $x metabolismus $x patologie $7 D010179
650    _2
$a radon $x aplikace a dávkování $7 D011886
650    12
$a streptozocin $7 D013311
650    _2
$a superoxiddismutasa $x metabolismus $7 D013482
650    _2
$a časové faktory $7 D013997
655    _2
$a časopisecké články $7 D016428
700    1_
$a Kataoka, T. $u Graduate School of Health Sciences, Okayama University, Okayama, Japan
700    1_
$a Teraoka, J. $u Graduate School of Health Sciences, Okayama University, Okayama, Japan
700    1_
$a Sakoda, A. $u Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency, Tomata-gun, Japan
700    1_
$a Tanaka, H. $u Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency, Tomata-gun, Japan
700    1_
$a Ishimori, Y. $u Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency, Tomata-gun, Japan
700    1_
$a Mitsunobu, F. $u Misasa Medical Center, Okayama University Hospital, Tohaku-gun, Japan
700    1_
$a Taguchi, T. $u Graduate School of Health Sciences, Okayama University, Okayama, Japan
700    1_
$a Yamaoka, K. $u Graduate School of Health Sciences, Okayama University, Okayama, Japan
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 62, č. 1 (2013), s. 57-66
856    41
$u http://www.biomed.cas.cz/physiolres/archive.htm $y domovská stránka časopisu - plný text volně přístupný = fulltext
910    __
$a ABA008 $b A 4120 $c 266 $y 3 $z 0
990    __
$a 20131015 $b ABA008
991    __
$a 20150310093804 $b ABA008
999    __
$a ok $b bmc $g 999111 $s 831814
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2013 $b 62 $c 1 $d 57-66 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK111 $a Pubmed-20131015

Najít záznam

Citační ukazatele

Možnosti archivace