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Molecular structure of purinergic P2X receptors and their expression in the hypothalamus and pituitary
H. Zemková, A. Balík, M. Jindrichová, V. Vávra
Language English Country Czech Republic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
IAA5011408
MZ0
CEP Register
IAA500110702
MZ0
CEP Register
NLK
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- MeSH
- Adenosine Triphosphate metabolism MeSH
- Gonadotrophs metabolism MeSH
- Pituitary Gland metabolism MeSH
- Hypothalamus metabolism MeSH
- Ivermectin chemistry pharmacology MeSH
- Protein Structure, Quaternary MeSH
- Humans MeSH
- Models, Molecular MeSH
- Neuroglia metabolism MeSH
- Neurons metabolism MeSH
- Receptors, Purinergic P2 chemistry drug effects metabolism MeSH
- Protein Structure, Secondary MeSH
- Protein Structure, Tertiary MeSH
- Protein Binding MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Purinergic P2X receptors represent a novel structural type of ligand-gated ion channels activated by extracellular ATP. So far, seven P2X receptor subunits have been found in excitable as well as non-excitable tissues. Little is known about their structure, mechanism of channel opening, localization, and role in the central nervous system. The aim of this work is to summarize recent investigations and describe our contribution to elucidating the structure of the ATP binding site and transmembrane domains of the P2X receptor, we also discuss the expression and physiological roles played by the ATP and P2X receptors in the anterior pituitary and hypothalamus.
References provided by Crossref.org
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