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Expression of alveolar macrophage adhesion molecules in pulmonary sarcoidosis
I Striz, YM Wang, O Kalaycioglu, U Costabel
Language English Country United States
Document type Research Support, Non-U.S. Gov't
Grant support
IZ71
MZ0
CEP Register
PubMed
1355420
Knihovny.cz E-resources
- MeSH
- Macrophages, Alveolar * immunology MeSH
- CD11 Antigens MeSH
- CD18 Antigens MeSH
- Bronchoalveolar Lavage Fluid cytology MeSH
- Antigens, CD * analysis MeSH
- Adult MeSH
- Immunoenzyme Techniques MeSH
- Integrins * analysis MeSH
- Humans MeSH
- Intercellular Adhesion Molecule-1 MeSH
- Cell Adhesion Molecules analysis MeSH
- Lung Diseases * immunology MeSH
- Receptors, Leukocyte-Adhesion immunology MeSH
- Sarcoidosis * immunology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Beta-2-integrins belong to a family of leukocyte surface glycoproteins that are essential for immune functions of bronchoalveolar cells. The expression of three alpha chains designed as CD11a, CD11b, CD11c, a common beta chain CD18, and of a ligand for several integrins CD54 (ICAM-1) was studied on alveolar macrophages of patients with active and inactive sarcoidosis and in control subjects. The percentage of macrophages expressing CD11b (CR3) was significantly increased in patients with active sarcoidosis compared with patients who had inactive disease and control subjects. The adhesion molecule CD54 (ICAM-1) was detected on a higher percentage of alveolar macrophages in patients with active rather than inactive sarcoidosis and in control subjects. Since integrin-mediated adhesion seems to be important in macrophage-lymphocyte interactions during the immune response, higher expression of both CD11b and CD54 on sarcoid alveolar macrophages may be related to several immune abnormalities reported in pulmonary sarcoidosis.
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- $a Beta-2-integrins belong to a family of leukocyte surface glycoproteins that are essential for immune functions of bronchoalveolar cells. The expression of three alpha chains designed as CD11a, CD11b, CD11c, a common beta chain CD18, and of a ligand for several integrins CD54 (ICAM-1) was studied on alveolar macrophages of patients with active and inactive sarcoidosis and in control subjects. The percentage of macrophages expressing CD11b (CR3) was significantly increased in patients with active sarcoidosis compared with patients who had inactive disease and control subjects. The adhesion molecule CD54 (ICAM-1) was detected on a higher percentage of alveolar macrophages in patients with active rather than inactive sarcoidosis and in control subjects. Since integrin-mediated adhesion seems to be important in macrophage-lymphocyte interactions during the immune response, higher expression of both CD11b and CD54 on sarcoid alveolar macrophages may be related to several immune abnormalities reported in pulmonary sarcoidosis.
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