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Relationship between serum bilirubin and uric acid to oxidative stress markers in Italian and Czech populations
Libor Vítek, Ladislav Novotný, Aleš Žák, Barbora Staňková, Tomáš Zima, Angelo Polito, Greco Cesare, Chiara Zerbinati, Luigi Iuliano
Language English Country Czech Republic
Document type Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 2003 to 2013
Freely Accessible Science Journals
from 2003 to 2013
ROAD: Directory of Open Access Scholarly Resources
from 2002
- MeSH
- White People MeSH
- Bilirubin * blood MeSH
- Biomarkers MeSH
- Cholesterol blood adverse effects MeSH
- Epidemiologic Studies MeSH
- Cardiovascular Diseases diet therapy epidemiology etiology MeSH
- Ketocholesterols blood adverse effects MeSH
- Uric Acid * blood MeSH
- Humans MeSH
- Multicenter Studies as Topic MeSH
- Oxidative Stress * MeSH
- Statistics as Topic MeSH
- Diet, Mediterranean ethnology MeSH
- Feeding Behavior MeSH
- Vitamin E MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Recently, a South-to-North oxidative stress marker gradient has been reported; consistent with known differences in the incidence of coronary heart disease between southern and northern European countries. The aim of the present study was to compare the plasma concentrations of 7-oxocholesterol (7OxCH) and 7beta-hydroxycholesterol (7BCH) with systemic antioxidants in healthy Italian and Czech subjects. The study was performed in healthy subjects of Italian (n=131) and Czech (n=84) origins. In all subjects routine biochemistry work-ups were performed; additionally, plasma oxysterols and the peroxyl radicals scavenging activity (PERSA) of the sera were determined. Close relationship of serum bilirubin and uric acid to markers of oxidative stress was observed in both examined populations. Compared to the Czechs, the Italian population showed higher plasma concentrations of both oxysterols (7OxCH: 3.6 vs. 6.0 ng/mL, p<10-6; 7BCH: 5.3 vs. 8.6 ng/mL, p<10-6), lower PERSA (p<10-6), and lower serum concentrations of bilirubin and uric acid (p<10-6 in both cases). The dietary patterns of the Italian population did not match the Mediterranean style, but was more similar to the Continental type of diet, presumably due to non-adherence to a Mediterranean diet.
4th Department of Internal Medicine 1st Faculty of Medicine of the Charles University Prague
Department Attilio Reale Sapienza University of Rome Rome Italy
Department of Medical Sciences and Biotechnology Sapienza University of Rome Rome Italy
Food and Nutrition National Research Institue Rome Italy
Institute of Medical Biochemistry and Laboratory Diagnostics
References provided by Crossref.org
Literatura
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