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Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
K. Pilatova, K. Greplova, R. Demlova, B. Bencsikova, GL. Klement, L. Zdrazilova-Dubska,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
NLK
BioMedCentral
from 2008-01-12
BioMedCentral Open Access
from 2008
Directory of Open Access Journals
from 2008
Free Medical Journals
from 2008
PubMed Central
from 2008
Europe PubMed Central
from 2008
ProQuest Central
from 2009-01-01
Open Access Digital Library
from 2008-01-01
Open Access Digital Library
from 2008-01-01
Medline Complete (EBSCOhost)
from 2009-01-17
Health & Medicine (ProQuest)
from 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2008
Springer Nature OA/Free Journals
from 2008-12-01
- MeSH
- Humans MeSH
- Neoplasms blood immunology pathology MeSH
- Neovascularization, Pathologic MeSH
- Peptides blood MeSH
- Platelet Factor 4 blood MeSH
- Blood Platelets metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers.
References provided by Crossref.org
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