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Cell-cycle checkpoints and cancer
MB Kastan, J Bartek
Language English Country England, Great Britain
NLK
Nature Journals Online
from 1997
Nature Journal Archive
from 1997
ProQuest Central
from 1990-01-04 to 1 year ago
Medline Complete (EBSCOhost)
from 1997-06-05 to 2015-11-26
Nursing & Allied Health Database (ProQuest)
from 1990-01-04 to 1 year ago
Health & Medicine (ProQuest)
from 1990-01-04 to 1 year ago
Psychology Database (ProQuest)
from 1990-01-04 to 1 year ago
Public Health Database (ProQuest)
from 1990-01-04 to 1 year ago
PubMed
15549093
Knihovny.cz E-resources
- MeSH
- Cell Cycle * MeSH
- Humans MeSH
- Neoplasms enzymology metabolism pathology MeSH
- DNA Damage MeSH
- Signal Transduction * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical determinants of whether that individual will develop cancer. These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA.
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- $a Kastan, M.B. $u Department of Hematology-Oncology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA. michael.kastan@stjude.org
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- $a All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical determinants of whether that individual will develop cancer. These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA.
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