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The role of adipose tissue immune cells in obesity and low-grade inflammation
M. Mraz, M. Haluzik,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
NT13299
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Zdroj
NLK
Free Medical Journals
od 1997-09-01 do Před 1 rokem
Open Access Digital Library
od 1939-01-01
Open Access Digital Library
od 1997-09-01
PubMed
25006217
DOI
10.1530/joe-14-0283
Knihovny.cz E-zdroje
- MeSH
- inzulinová rezistence imunologie MeSH
- lidé MeSH
- lymfocyty imunologie patologie MeSH
- myeloidní buňky imunologie patologie MeSH
- obezita etiologie imunologie patologie MeSH
- tuková tkáň imunologie metabolismus patologie MeSH
- zánět etiologie imunologie patologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Adipose tissue (AT) lies at the crossroad of nutrition, metabolism, and immunity; AT inflammation was proposed as a central mechanism connecting obesity with its metabolic and vascular complications. Resident immune cells constitute the second largest AT cellular component after adipocytes and as such play important roles in the maintenance of AT homeostasis. Obesity-induced changes in their number and activity result in the activation of local and later systemic inflammatory response, marking the transition from simple adiposity to diseases such as type 2 diabetes mellitus, arterial hypertension, and ischemic heart disease. This review has focused on the various subsets of immune cells in AT and their role in the development of AT inflammation and obesity-induced insulin resistance.
Citace poskytuje Crossref.org
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