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The role of adipose tissue immune cells in obesity and low-grade inflammation
M. Mraz, M. Haluzik,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
NT13299
MZ0
CEP Register
Digital library NLK
Full text - Article
Source
NLK
Free Medical Journals
from 1997-09-01 to 1 year ago
PubMed
25006217
DOI
10.1530/joe-14-0283
Knihovny.cz E-resources
- MeSH
- Insulin Resistance immunology MeSH
- Humans MeSH
- Lymphocytes immunology pathology MeSH
- Myeloid Cells immunology pathology MeSH
- Obesity etiology immunology pathology MeSH
- Adipose Tissue immunology metabolism pathology MeSH
- Inflammation etiology immunology pathology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Adipose tissue (AT) lies at the crossroad of nutrition, metabolism, and immunity; AT inflammation was proposed as a central mechanism connecting obesity with its metabolic and vascular complications. Resident immune cells constitute the second largest AT cellular component after adipocytes and as such play important roles in the maintenance of AT homeostasis. Obesity-induced changes in their number and activity result in the activation of local and later systemic inflammatory response, marking the transition from simple adiposity to diseases such as type 2 diabetes mellitus, arterial hypertension, and ischemic heart disease. This review has focused on the various subsets of immune cells in AT and their role in the development of AT inflammation and obesity-induced insulin resistance.
References provided by Crossref.org
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