• Je něco špatně v tomto záznamu ?

Kinetics of neurotransmitter release in neuromuscular synapses of newborn and adult rats

V. Khuzakhmetova, D. Samigullin, L. Nurullin, F. Vyskočil, E. Nikolsky, E. Bukharaeva,

. 2014 ; 34 (-) : 9-18.

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc15008406

The kinetics of the phasic synchronous and delayed asynchronous release of acetylcholine quanta was studied at the neuromuscular junctions of aging rats from infant to mature animals at various frequencies of rhythmic stimulation of the motor nerve. We found that in infants 6 (P6) and 10 (P10) days after birth a strongly asynchronous phase of quantal release was observed, along with a reduced number of quanta compared to the synapses of adults. The rise time and decay of uni-quantal end-plate currents were significantly longer in infant synapses. The presynaptic immunostaining revealed that the area of the synapses in infants was significantly (up to six times) smaller than in mature junctions. The intensity of delayed asynchronous release in infants increased with the frequency of stimulation more than in adults. A blockade of the ryanodine receptors, which can contribute to the formation of delayed asynchronous release, had no effect on the kinetics of delayed secretion in the infants unlike synapses of adults. Therefore, high degree of asynchrony of quantal release in infants is not associated with the activity of ryanodine receptors and with the liberation of calcium ions from intracellular calcium stores.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc15008406
003      
CZ-PrNML
005      
20150325111833.0
007      
ta
008      
150306s2014 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ijdevneu.2013.12.010 $2 doi
035    __
$a (PubMed)24412779
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Khuzakhmetova, Venera $u Kazan Institute of Biochemistry and Biophysics Kazan Scientific Center of the Russian Academy of Sciences, Post Box 30, 420111 Kazan, Russia.
245    10
$a Kinetics of neurotransmitter release in neuromuscular synapses of newborn and adult rats / $c V. Khuzakhmetova, D. Samigullin, L. Nurullin, F. Vyskočil, E. Nikolsky, E. Bukharaeva,
520    9_
$a The kinetics of the phasic synchronous and delayed asynchronous release of acetylcholine quanta was studied at the neuromuscular junctions of aging rats from infant to mature animals at various frequencies of rhythmic stimulation of the motor nerve. We found that in infants 6 (P6) and 10 (P10) days after birth a strongly asynchronous phase of quantal release was observed, along with a reduced number of quanta compared to the synapses of adults. The rise time and decay of uni-quantal end-plate currents were significantly longer in infant synapses. The presynaptic immunostaining revealed that the area of the synapses in infants was significantly (up to six times) smaller than in mature junctions. The intensity of delayed asynchronous release in infants increased with the frequency of stimulation more than in adults. A blockade of the ryanodine receptors, which can contribute to the formation of delayed asynchronous release, had no effect on the kinetics of delayed secretion in the infants unlike synapses of adults. Therefore, high degree of asynchrony of quantal release in infants is not associated with the activity of ryanodine receptors and with the liberation of calcium ions from intracellular calcium stores.
650    _2
$a věkové faktory $7 D000367
650    _2
$a zvířata $7 D000818
650    _2
$a novorozená zvířata $7 D000831
650    _2
$a bungarotoxiny $x farmakokinetika $7 D002038
650    _2
$a elektrická stimulace $7 D004558
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a kyselina gallová $x analogy a deriváty $x farmakokinetika $7 D005707
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a nervosvalové spojení $x účinky léků $x růst a vývoj $x metabolismus $7 D009469
650    _2
$a neurotransmiterové látky $x metabolismus $7 D018377
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a reakční čas $x fyziologie $7 D011930
650    _2
$a nikotinové receptory $x metabolismus $7 D011978
650    _2
$a ryanodin $x farmakokinetika $7 D012433
650    _2
$a synaptické potenciály $x fyziologie $7 D055366
650    _2
$a synaptofysin $x metabolismus $7 D016708
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Samigullin, Dmitry $u Kazan Institute of Biochemistry and Biophysics Kazan Scientific Center of the Russian Academy of Sciences, Post Box 30, 420111 Kazan, Russia.
700    1_
$a Nurullin, Leniz $u Kazan Institute of Biochemistry and Biophysics Kazan Scientific Center of the Russian Academy of Sciences, Post Box 30, 420111 Kazan, Russia.
700    1_
$a Vyskočil, Frantisek $u Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 14200 Prague, Czech Republic; Department of Physiology, Faculty of Sciences, Charles University, Vinicna 7, Prague, Czech Republic.
700    1_
$a Nikolsky, Evgeny $u Kazan Institute of Biochemistry and Biophysics Kazan Scientific Center of the Russian Academy of Sciences, Post Box 30, 420111 Kazan, Russia; Kazan State Medical University, Butlerov st. 49, 420012 Kazan, Russia; Kazan Federal University, Kremlyovskaya st. 18, 420008 Kazan, Russia.
700    1_
$a Bukharaeva, Ellya $u Kazan Institute of Biochemistry and Biophysics Kazan Scientific Center of the Russian Academy of Sciences, Post Box 30, 420111 Kazan, Russia; Kazan State Medical University, Butlerov st. 49, 420012 Kazan, Russia; Kazan Federal University, Kremlyovskaya st. 18, 420008 Kazan, Russia. Electronic address: elbukhara@gmail.com.
773    0_
$w MED00002312 $t International journal of developmental neuroscience the official journal of the International Society for Developmental Neuroscience $x 1873-474X $g Roč. 34, č. - (2014), s. 9-18
856    41
$u https://pubmed.ncbi.nlm.nih.gov/24412779 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20150306 $b ABA008
991    __
$a 20150325112122 $b ABA008
999    __
$a ok $b bmc $g 1065679 $s 891206
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 34 $c - $d 9-18 $i 1873-474X $m International journal of developmental neuroscience $n Int J Dev Neurosci $x MED00002312
LZP    __
$a Pubmed-20150306

Najít záznam

Citační ukazatele

Možnosti archivace