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Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
DE. Arking, SL. Pulit, L. Crotti, P. van der Harst, PB. Munroe, TT. Koopmann, N. Sotoodehnia, EJ. Rossin, M. Morley, X. Wang, AD. Johnson, A. Lundby, DF. Gudbjartsson, PA. Noseworthy, M. Eijgelsheim, Y. Bradford, KV. Tarasov, M. Dörr, M....
Nature genetics.
2014 ;
46 (8) :
826-36.
Language English Country United States
Document type Journal Article, Meta-Analysis
Persistent link
https://www.medvik.cz/link/bmc15014200
Online
Full text
NLK
ProQuest Central
from 2000-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 1998-06-01 to 2015-11-30
Health & Medicine (ProQuest)
from 2000-01-01 to 1 year ago
Public Health Database (ProQuest)
from 2000-01-01 to 1 year ago
PubMed
24952745
DOI
10.1038/ng.3014
Knihovny.cz E-resources
- MeSH
- Genome-Wide Association Study methods MeSH
- Adult MeSH
- Electrocardiography methods MeSH
- Genetic Predisposition to Disease MeSH
- Genotype MeSH
- Polymorphism, Single Nucleotide MeSH
- Middle Aged MeSH
- Humans MeSH
- Myocardium metabolism MeSH
- Death, Sudden, Cardiac etiology MeSH
- Aged MeSH
- Arrhythmias, Cardiac genetics metabolism MeSH
- Heart Ventricles metabolism MeSH
- Long QT Syndrome genetics metabolism MeSH
- Calcium Signaling genetics MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Meta-Analysis MeSH
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.
] deCODE genetics Reykjavik Iceland [2] Faculty of Medicine University of Iceland Reykjavik Iceland
Biomedical Sciences St George's University of London London UK
California Pacific Medical Center Research Institute San Francisco California USA
Cardiovascular and Cell Sciences Institute St George's University of London London UK
Cardiovascular Department Ospedali Riuniti and University of Trieste Trieste Italy
Center for Biomedicine European Academy Bozen Bolzano
Center for Human Genetics Research Vanderbilt University School of Medicine Nashville Tennessee USA
Center for Systems Genomics Pennsylvania State University University Park Pennsylvania USA
Centre for Population Health Sciences University of Edinburgh Edinburgh UK
Clinical Pharmacology University of Cambridge Addenbrooke's Hospital Cambridge UK
Department of Biology Massachusetts Institute of Technology Cambridge Massachusetts USA
Department of Biomedical Engineering Johns Hopkins University Baltimore Maryland USA
Department of Cardiology University Hospital of Essen University Duisburg Essen Essen Germany
Department of Cardiovascular Science University of Leicester Glenfield Hospital Leicester UK
Department of Clinical Genetics Academic Medical Center Amsterdam The Netherlands
Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands
Department of Medical Informatics Erasmus Medical Center Rotterdam The Netherlands
Department of Medical Sciences Uppsala University Uppsala Sweden
Department of Medicine 1 University Hospital Munich Ludwig Maximilians Universität Munich Germany
Department of Medicine 3 Medical Faculty Martin Luther University Halle Wittenberg Halle Germany
Department of Medicine Division of Cardiology Helsinki University Central Hospital Helsinki Finland
Department of Medicine Division of Cardiology Landspitali University Hospital Reykjavik Iceland
Department of Medicine Turku University Hospital and University of Turku Turku Finland
Department of Medicine University of Helsinki Helsinki Finland
Department of Neurology Innsbruck Medical University Innsbruck Austria
Department of Pharmacology Ernst Moritz Arndt University of Greifswald Greifswald Germany
Department of Public Health Faculty of Medicine University of Split Split Croatia
Department of Twin Research and Genetic Epidemiology King's College London London UK
Division of Genetic Epidemiology Innsbruck Medical University Innsbruck Austria
Division of Population Health Sciences and Education St George's University of London London UK
eCODE genetics Reykjavik Iceland
General Practice and Primary Care University of Glasgow Glasgow UK
Human Genetics Research Centre St George's University of London London UK
Icelandic Heart Association Kopavogur Iceland
Informatics and Biocomputing Platform Ontario Institute for Cancer Research Toronto Ontario Canada
Institut du Thorax INSERM UMR1087 CNRS UMR 6291 Université de Nantes Nantes France
Institute for Community Medicine University Medicine Greifswald Greifswald Germany
Institute for Maternal and Child Health Burlo Garofolo Trieste Trieste Italy
Institute of Cardiovascular Science University College London London UK
Institute of Clinical Molecular Biology Christian Albrechts University of Kiel Kiel Germany
Laboratory of Epidemiology Demography and Biometry National Institute on Aging Bethesda Maryland USA
Medical Genetics Unit Casa Sollievo della Sofferenza San Giovanni Rotondo Italy
National Heart Lung and Blood Institute Framingham Heart Study Framingham Massachusetts USA
Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA
Sanofi Research and Development Paris France
The Centre for Applied Genomics The Hospital for Sick Children Toronto Ontario Canada
Translational Gerontology Branch National Institute on Aging Baltimore Maryland USA
References provided by Crossref.org
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- $a The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- $a Psaty, Bruce M $u 1] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA. [2] Department of Epidemiology, University of Washington, Seattle, Washington, USA. [3] Department of Health Services, University of Washington, Seattle, Washington, USA. [4] Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA. [5] Department of Medicine, University of Washington, Seattle, Washington, USA.
- 700 1_
- $a Rotter, Jerome I $u Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (UCLA) Medical Center, Torrance, California, USA.
- 700 1_
- $a Kolcic, Ivana $u Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
- 700 1_
- $a Polašek, Ozren $u Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
- 700 1_
- $a Wright, Alan F $u Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
- 700 1_
- $a Griffin, Maura $u Vascular Screening and Diagnostic Centre, London, UK.
- 700 1_
- $a Daly, Mark J $u 1] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [2] Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
- 700 1_
- $a ,
- 700 1_
- $a Arnar, David O $u Department of Medicine, Division of Cardiology, Landspitali University Hospital, Reykjavik, Iceland.
- 700 1_
- $a Hólm, Hilma $u deCODE genetics, Reykjavik, Iceland.
- 700 1_
- $a Thorsteinsdottir, Unnur $u deCODE genetics, Reykjavik, Iceland.
- 700 1_
- $a ,
- 700 1_
- $a Denny, Joshua C $u 1] Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. [2] Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
- 700 1_
- $a Roden, Dan M $u 1] Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. [2] Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA. [3] Office of Personalized Medicine, Vanderbilt University, Nashville, Tennessee, USA.
- 700 1_
- $a Zuvich, Rebecca L $u Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
- 700 1_
- $a Emilsson, Valur $u Icelandic Heart Association, Kopavogur, Iceland.
- 700 1_
- $a Plump, Andrew S $u Sanofi Research and Development, Paris, France.
- 700 1_
- $a Larson, Martin G $u 1] National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts, USA. [2] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. [3] Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, USA.
- 700 1_
- $a O'Donnell, Christopher J $u 1] National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts, USA. [2] Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA.
- 700 1_
- $a Yin, Xiaoyan $u 1] National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts, USA. [2] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
- 700 1_
- $a Bobbo, Marco $u Cardiovascular Department, Ospedali Riuniti and University of Trieste, Trieste, Italy.
- 700 1_
- $a D'Adamo, Adamo P $u 1] Institute for Maternal and Child Health, "Burlo Garofolo" Trieste, Trieste, Italy. [2] Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
- 700 1_
- $a Iorio, Annamaria $u Cardiovascular Department, Ospedali Riuniti and University of Trieste, Trieste, Italy.
- 700 1_
- $a Sinagra, Gianfranco $u Cardiovascular Department, Ospedali Riuniti and University of Trieste, Trieste, Italy.
- 700 1_
- $a Carracedo, Angel $u 1] Grupo de Medicina Xenómica, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Universidade de Santiago de Compostela, Santiago de Compostela, Spain. [2] Fundación Publica Galega de Medicina Xenómica, Servicio Galego de Saude, Santiago de Compostela, Spain. [3] Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
- 700 1_
- $a Cummings, Steven R $u California Pacific Medical Center Research Institute, San Francisco, California, USA.
- 700 1_
- $a Nalls, Michael A $u Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
- 700 1_
- $a Jula, Antti $u Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
- 700 1_
- $a Kontula, Kimmo K $u Department of Medicine, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Marjamaa, Annukka $u 1] Research Programs Unit, Molecular Medicine, University of Helsinki, Helsinki, Finland. [2] Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
- 700 1_
- $a Oikarinen, Lasse $u Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland.
- 700 1_
- $a Perola, Markus $u 1] Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland. [2] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [3] Estonian Genome Center, University of Tartu, Tartu, Estonia.
- 700 1_
- $a Porthan, Kimmo $u Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland.
- 700 1_
- $a Erbel, Raimund $u Department of Cardiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
- 700 1_
- $a Hoffmann, Per $u 1] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. [2] Institute of Human Genetics, University of Bonn, Bonn, Germany. [3] Division of Medical Genetics, University Hospital Basel, Basel, Switzerland. [4] Department of Biomedicine, University of Basel, Basel, Switzerland.
- 700 1_
- $a Jöckel, Karl-Heinz $u Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
- 700 1_
- $a Kälsch, Hagen $u Department of Cardiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
- 700 1_
- $a Nöthen, Markus M $u 1] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. [2] Institute of Human Genetics, University of Bonn, Bonn, Germany.
- 700 1_
- $a ,
- 700 1_
- $a den Hoed, Marcel $u 1] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] MRC Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
- 700 1_
- $a Loos, Ruth J F $u 1] MRC Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. [2] Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [3] Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
- 700 1_
- $a Thelle, Dag S $u 1] Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. [2] Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
- 700 1_
- $a Gieger, Christian $u Institute of Genetic Epidemiology, Helmholtz Zentrum Munich-German Research Center for Environmental Health, Neuherberg, Germany.
- 700 1_
- $a Meitinger, Thomas $u 1] DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. [2] Institute of Human Genetics, Technische Universität München, Munich, Germany. [3] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
- 700 1_
- $a Perz, Siegfried $u Institute for Biological and Medical Imaging, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
- 700 1_
- $a Peters, Annette $u 1] DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. [2] Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
- 700 1_
- $a Prucha, Hanna $u 1] Christine Kühne-Center for Allergy and Education, Munich, Germany. [2] Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.
- 700 1_
- $a Sinner, Moritz F $u Department of Medicine I, University Hospital Munich, Ludwig Maximilians Universität, Munich, Germany.
- 700 1_
- $a Waldenberger, Melanie $u Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
- 700 1_
- $a de Boer, Rudolf A $u Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 700 1_
- $a Franke, Lude $u Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 700 1_
- $a van der Vleuten, Pieter A $u 1] Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. [2] Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 700 1_
- $a Beckmann, Britt Maria $u Department of Medicine I, University Hospital Munich, Ludwig Maximilians Universität, Munich, Germany.
- 700 1_
- $a Martens, Eimo $u 1] Department of Medicine I, University Hospital Munich, Ludwig Maximilians Universität, Munich, Germany. [2] Department of Medicine, Hospital of Friedberg, Friedberg, Germany.
- 700 1_
- $a Bardai, Abdennasser $u Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
- 700 1_
- $a Hofman, Nynke $u Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands.
- 700 1_
- $a Wilde, Arthur A M $u 1] Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands. [2] Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Saudi Arabia.
- 700 1_
- $a Behr, Elijah R $u Cardiovascular and Cell Sciences Institute, St George's University of London, London, UK.
- 700 1_
- $a Dalageorgou, Chrysoula $u Biomedical Sciences, St George's University of London, London, UK.
- 700 1_
- $a Giudicessi, John R $u Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.
- 700 1_
- $a Medeiros-Domingo, Argelia $u Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.
- 700 1_
- $a Barc, Julien $u Institut du Thorax, INSERM UMR1087, CNRS UMR 6291, Université de Nantes, Nantes, France.
- 700 1_
- $a Kyndt, Florence $u 1] Institut du Thorax, Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France. [2] Institut du Thorax, INSERM UMR1087, CNRS UMR 6291, Université de Nantes, Nantes, France.
- 700 1_
- $a Probst, Vincent $u 1] Institut du Thorax, Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France. [2] Institut du Thorax, INSERM UMR1087, CNRS UMR 6291, Université de Nantes, Nantes, France.
- 700 1_
- $a Ghidoni, Alice $u 1] Department of Molecular Medicine, Section of Cardiology, University of Pavia, Pavia, Italy. [2] Center for Cardiac Arrhythmias of Genetic Origin, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Auxologico Italiano, Milan, Italy.
- 700 1_
- $a Insolia, Roberto $u 1] Department of Molecular Medicine, Section of Cardiology, University of Pavia, Pavia, Italy. [2] Center for Cardiac Arrhythmias of Genetic Origin, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Auxologico Italiano, Milan, Italy.
- 700 1_
- $a Hamilton, Robert M $u 1] The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
- 700 1_
- $a Scherer, Stephen W $u The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.
- 700 1_
- $a Brandimarto, Jeffrey $u Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
- 700 1_
- $a Margulies, Kenneth $u Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
- 700 1_
- $a Moravec, Christine E $u Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
- 700 1_
- $a del Greco M, Fabiola $u Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck, Lübeck, Germany).
- 700 1_
- $a Fuchsberger, Christian $u Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
- 700 1_
- $a O'Connell, Jeffrey R $u 1] Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. [2] Program for Personalized and Genomic Medicine, University of Maryland, Baltimore, Maryland, USA.
- 700 1_
- $a Lee, Wai K $u BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
- 700 1_
- $a Watt, Graham C M $u General Practice and Primary Care, University of Glasgow, Glasgow, UK.
- 700 1_
- $a Campbell, Harry $u Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a Wild, Sarah H $u Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a El Mokhtari, Nour E $u Biobank PopGen, Institute of Experimental Medicine, Christian Albrechts University of Kiel, Kiel, Germany.
- 700 1_
- $a Frey, Norbert $u Department of Internal Medicine III, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
- 700 1_
- $a Asselbergs, Folkert W $u 1] Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of The Netherlands-Netherlands Heart Institute, Utrecht, The Netherlands. [2] Department of Cardiology, Division of Heart and Lungs, University Medical Centre Utrecht, Utrecht, The Netherlands. [3] Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.
- 700 1_
- $a Mateo Leach, Irene $u Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 700 1_
- $a Navis, Gerjan $u Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 700 1_
- $a van den Berg, Maarten P $u Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 700 1_
- $a van Veldhuisen, Dirk J $u Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 700 1_
- $a Kellis, Manolis $u 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
- 700 1_
- $a Krijthe, Bouwe P $u 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands.
- 700 1_
- $a Franco, Oscar H $u 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands.
- 700 1_
- $a Hofman, Albert $u 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands.
- 700 1_
- $a Kors, Jan A $u Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands.
- 700 1_
- $a Uitterlinden, André G $u 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands. [3] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
- 700 1_
- $a Witteman, Jacqueline C M $u 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands.
- 700 1_
- $a Kedenko, Lyudmyla $u First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Salzburg, Austria.
- 700 1_
- $a Lamina, Claudia $u Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria.
- 700 1_
- $a Oostra, Ben A $u Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
- 700 1_
- $a Abecasis, Gonçalo R $u Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
- 700 1_
- $a Lakatta, Edward G $u Laboratory of Cardiovascular Sciences, Human Cardiovascular Studies Unit, National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA.
- 700 1_
- $a Mulas, Antonella $u Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
- 700 1_
- $a Orrú, Marco $u Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
- 700 1_
- $a Schlessinger, David $u Laboratory of Genetics, Intramural Research Program, National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA.
- 700 1_
- $a Uda, Manuela $u Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
- 700 1_
- $a Markus, Marcello R P $u Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
- 700 1_
- $a Völker, Uwe $u 1] DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. [2] Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt University Greifswald, Greifswald, Germany.
- 700 1_
- $a Snieder, Harold $u Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 700 1_
- $a Spector, Timothy D $u Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
- 700 1_
- $a Ärnlöv, Johan $u 1] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] School of Health and Social Sciences, Dalarna University, Falun, Sweden.
- 700 1_
- $a Lind, Lars $u Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
- 700 1_
- $a Sundström, Johan $u Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
- 700 1_
- $a Syvänen, Ann-Christine $u Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
- 700 1_
- $a Kivimaki, Mika $u Institute of Cardiovascular Science, University College London, London, UK.
- 700 1_
- $a Kähönen, Mika $u Department of Clinical Physiology, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland.
- 700 1_
- $a Mononen, Nina $u Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
- 700 1_
- $a Raitakari, Olli T $u 1] Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. [2] Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
- 700 1_
- $a Viikari, Jorma S $u Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland.
- 700 1_
- $a Adamkova, Vera $u Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
- 700 1_
- $a Kiechl, Stefan $u Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
- 700 1_
- $a Brion, Maria $u 1] Grupo de Medicina Xenómica, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Universidade de Santiago de Compostela, Santiago de Compostela, Spain. [2] Xenética de Enfermidades Cardiovasculares e Oftalmolóxicas, Complexo Hospitalario Universitario de Santiago de Compostela, Servicio Galego de Saude, Santiago de Compostela, Spain.
- 700 1_
- $a Nicolaides, Andrew N $u 1] Cyprus Cardiovascular and Educational Research Trust, Nicosia, Cyprus. [2] Vascular Screening and Diagnostic Centre, London, UK.
- 700 1_
- $a Paulweber, Bernhard $u First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Salzburg, Austria.
- 700 1_
- $a Haerting, Johannes $u Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle-Wittenberg, Halle, Germany.
- 700 1_
- $a Dominiczak, Anna F $u BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
- 700 1_
- $a Nyberg, Fredrik $u 1] Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. [2] Global Epidemiology, AstraZeneca Research and Development, Mölndal, Sweden.
- 700 1_
- $a Whincup, Peter H $u Division of Population Health Sciences and Education, St George's University of London, London, UK.
- 700 1_
- $a Hingorani, Aroon D $u Institute of Cardiovascular Science, University College London, London, UK.
- 700 1_
- $a Schott, Jean-Jacques $u 1] Institut du Thorax, Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France. [2] Institut du Thorax, INSERM UMR1087, CNRS UMR 6291, Université de Nantes, Nantes, France.
- 700 1_
- $a Bezzina, Connie R $u Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
- 700 1_
- $a Ingelsson, Erik $u 1] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
- 700 1_
- $a Ferrucci, Luigi $u Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA.
- 700 1_
- $a Gasparini, Paolo $u 1] Institute for Maternal and Child Health, "Burlo Garofolo" Trieste, Trieste, Italy. [2] Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
- 700 1_
- $a Wilson, James F $u Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a Rudan, Igor $u Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a Franke, Andre $u Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
- 700 1_
- $a Mühleisen, Thomas W $u 1] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. [2] Institute of Human Genetics, University of Bonn, Bonn, Germany. [3] Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Centre Juelich, Juelich, Germany.
- 700 1_
- $a Pramstaller, Peter P $u 1] Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck, Lübeck, Germany). [2] Department of Neurology, University of Lübeck, Lübeck, Germany. [3] Department of Neurology, General Central Hospital, Bolzano, Italy.
- 700 1_
- $a Lehtimäki, Terho J $u Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
- 700 1_
- $a Paterson, Andrew D $u Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
- 700 1_
- $a Parsa, Afshin $u 1] Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. [2] Program for Personalized and Genomic Medicine, University of Maryland, Baltimore, Maryland, USA.
- 700 1_
- $a Liu, Yongmei $u Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, USA.
- 700 1_
- $a van Duijn, Cornelia M $u Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
- 700 1_
- $a Siscovick, David S $u 1] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA. [2] Department of Epidemiology, University of Washington, Seattle, Washington, USA. [3] Department of Medicine, University of Washington, Seattle, Washington, USA.
- 700 1_
- $a Gudnason, Vilmundur $u 1] Icelandic Heart Association, Kopavogur, Iceland. [2] Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
- 700 1_
- $a Jamshidi, Yalda $u Human Genetics Research Centre, St George's University of London, London, UK.
- 700 1_
- $a Salomaa, Veikko $u Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
- 700 1_
- $a Felix, Stephan B $u 1] Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany. [2] DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
- 700 1_
- $a Sanna, Serena $u Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
- 700 1_
- $a Ritchie, Marylyn D $u Center for Systems Genomics, Pennsylvania State University, University Park, Pennsylvania, USA.
- 700 1_
- $a Stricker, Bruno H $u 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. [2] Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands. [3] Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands. [4] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. [5] Inspectorate of Health Care, The Hague, The Netherlands.
- 700 1_
- $a Stefansson, Kari $u 1] deCODE genetics, Reykjavik, Iceland. [2] Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
- 700 1_
- $a Boyer, Laurie A $u Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
- 700 1_
- $a Cappola, Thomas P $u Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
- 700 1_
- $a Olsen, Jesper V $u Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
- 700 1_
- $a Lage, Kasper $u 1] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [2] Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. [3] Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. [4] Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark. [5] Pediatric Surgical Research Laboratories, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, Massachusetts, USA.
- 700 1_
- $a Schwartz, Peter J $u Center for Cardiac Arrhythmias of Genetic Origin, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Auxologico Italiano, Milan, Italy.
- 700 1_
- $a Kääb, Stefan $u 1] Department of Medicine I, University Hospital Munich, Ludwig Maximilians Universität, Munich, Germany. [2] DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
- 700 1_
- $a Chakravarti, Aravinda $u Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
- 700 1_
- $a Ackerman, Michael J $u 1] Department of Pediatrics, Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota, USA. [2] Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA. [3] Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA. [4].
- 700 1_
- $a Pfeufer, Arne $u 1] Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck, Lübeck, Germany). [2] Institute of Human Genetics, Technische Universität München, Munich, Germany. [3] Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum, Munich, Germany. [4].
- 700 1_
- $a de Bakker, Paul I W $u 1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. [3].
- 700 1_
- $a Newton-Cheh, Christopher $u 1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. [5].
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