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Pilot study: Association between Helicobacter pylori in adenoid hyperplasia and reflux episodes detected by multiple intraluminal impedance in children
R. Katra, Z. Kabelka, M. Jurovcik, O. Hradsky, J. Kraus, E. Pavlik, E. Nartova, P. Lukes, J. Astl,
Jazyk angličtina Země Irsko
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NT11523
MZ0
CEP - Centrální evidence projektů
- MeSH
- adenoidy mikrobiologie patologie MeSH
- dítě MeSH
- DNA bakterií izolace a purifikace MeSH
- elektrická impedance MeSH
- Helicobacter pylori genetika izolace a purifikace MeSH
- hyperplazie MeSH
- infekce vyvolané Helicobacter pylori diagnóza MeSH
- kvantitativní polymerázová řetězová reakce MeSH
- laryngofaryngeální reflux diagnóza MeSH
- lidé MeSH
- monitorování jícnového pH MeSH
- pilotní projekty MeSH
- předškolní dítě MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
OBJECTIVES: The aim of this pilot study was to investigate an association between laryngopharyngeal reflux detected by combined multiple intraluminal impedance and pH monitoring and Helicobacter pylori in adenoid hyperplasia detected with real time polymerase chain reaction (PCR). METHODS: The study group consisted of 30 children (median age 5.34 years) with extraesophageal symptoms of gastroesophageal reflux disease with adenoid hyperplasia. All children underwent adenoidectomy with subsequent PCR detection of H. pylori DNA in the tissue and multiple intraluminal impedance and pH monitoring. The most proximal impedance sensor was located 1cm caudal to the entrance of the oesophagus. RESULTS: We found significant differences in the number of reflux episodes among patients with PCR positivity (median 35) and negativity (median 0) of H. pylori (p-value of Mann-Whitney U-test 0.0056). Patients with PCR positivity of H. pylori had significantly more reflux episodes reaching the upper oesophageal sphincter (p-value of Mann-Whitney U-test 0.023). The absence of reflux episode was the only independent factor for PCR negativity of H. pylori in the multiple logistic regression model. CONCLUSIONS: These results support the hypothesis that reflux episodes reaching the upper oesophageal sphincter may play an important role in the transmission of H. pylori into lymphoid tissue of the nasopharynx and thus may contribute to adenoid hyperplasia in children.
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- $a 10.1016/j.ijporl.2014.04.040 $2 doi
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- $a Katra, Rami $u Department of ENT, 2nd Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic. Electronic address: rami.katra@centrum.cz. $7 xx0228242
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- $a Pilot study: Association between Helicobacter pylori in adenoid hyperplasia and reflux episodes detected by multiple intraluminal impedance in children / $c R. Katra, Z. Kabelka, M. Jurovcik, O. Hradsky, J. Kraus, E. Pavlik, E. Nartova, P. Lukes, J. Astl,
- 520 9_
- $a OBJECTIVES: The aim of this pilot study was to investigate an association between laryngopharyngeal reflux detected by combined multiple intraluminal impedance and pH monitoring and Helicobacter pylori in adenoid hyperplasia detected with real time polymerase chain reaction (PCR). METHODS: The study group consisted of 30 children (median age 5.34 years) with extraesophageal symptoms of gastroesophageal reflux disease with adenoid hyperplasia. All children underwent adenoidectomy with subsequent PCR detection of H. pylori DNA in the tissue and multiple intraluminal impedance and pH monitoring. The most proximal impedance sensor was located 1cm caudal to the entrance of the oesophagus. RESULTS: We found significant differences in the number of reflux episodes among patients with PCR positivity (median 35) and negativity (median 0) of H. pylori (p-value of Mann-Whitney U-test 0.0056). Patients with PCR positivity of H. pylori had significantly more reflux episodes reaching the upper oesophageal sphincter (p-value of Mann-Whitney U-test 0.023). The absence of reflux episode was the only independent factor for PCR negativity of H. pylori in the multiple logistic regression model. CONCLUSIONS: These results support the hypothesis that reflux episodes reaching the upper oesophageal sphincter may play an important role in the transmission of H. pylori into lymphoid tissue of the nasopharynx and thus may contribute to adenoid hyperplasia in children.
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- $a Kabelka, Zdeněk, $u Department of ENT, 2nd Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic. $d 1951-2014 $7 xx0053507
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- $a Hradský, Ondřej, $u Department of Paediatrics, 2nd Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic. $d 1980- $7 xx0127568
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- $a Kraus, Jaroslav $u Department of Otorhinolaryngology, Hospital Rudolph and Stephanie, Benešov, Czech Republic. $7 xx0083598
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- $a Nártová, Eva, $u Department of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic. $d 1984- $7 xx0214480
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- $a Astl, Jaromír $u Department of ENT, 3rd Faculty of Medicine, Charles University, Military University Hospital, Prague, Czech Republic. $7 jn20020716588
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- $w MED00002355 $t International journal of pediatric otorhinolaryngology $x 1872-8464 $g Roč. 78, č. 8 (2014), s. 1243-1249
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