Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25623260
DOI
10.1016/j.fitote.2015.01.012
PII: S0367-326X(15)00014-3
Knihovny.cz E-zdroje
- Klíčová slova
- Dextran sulfate sodium (DSS), Diplacone, Diplacone (PubChem CID: 14539948), Geranylated flavanones, In vivo, Mimulone, Mimulone (PubChem CID: 5716903), Sulfasalazine (PubChem CID: 5353980), Ulcerative colitis,
- MeSH
- cyklooxygenasa 2 metabolismus MeSH
- flavanony farmakologie MeSH
- katalasa metabolismus MeSH
- kolitida chemicky indukované farmakoterapie MeSH
- kolon účinky léků patofyziologie MeSH
- matrixová metaloproteinasa 2 metabolismus MeSH
- modely nemocí na zvířatech MeSH
- molekulární struktura MeSH
- potkani Wistar MeSH
- síran dextranu škodlivé účinky MeSH
- superoxiddismutasa metabolismus MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- cyklooxygenasa 2 MeSH
- diplacone MeSH Prohlížeč
- flavanony MeSH
- katalasa MeSH
- matrixová metaloproteinasa 2 MeSH
- mimulone MeSH Prohlížeč
- Mmp2 protein, rat MeSH Prohlížeč
- Ptgs2 protein, rat MeSH Prohlížeč
- síran dextranu MeSH
- superoxiddismutasa MeSH
- superoxide dismutase 2 MeSH Prohlížeč
Diplacone (1) and mimulone (2), two geranylated flavanones, have previously shown anti-inflammatory and antiradical activity in vitro. The present study aimed to evaluate their activity in vivo on a model of colitis induced in Wistar rats by an oral administration of dextran sulfate sodium (DSS). Diplacone (1) and mimulone (2) were administered at a bolus dose of 25mg/kg by gastric gavage 48 and 24h prior to the induction of colitis by DSS and every 24h on the following days of the experiment. The effect of the treatment was assessed by monitoring the disease activity index (DAI), histopathological examination, evaluation of the weight and length of the colon and by analysis of the levels and activities of cyclooxygenase-2 (COX-2), matrix metalloproteinase-2 (MMP2), superoxide dismutase-2 (SOD2), and catalase (CAT) in the inflamed tissue. Administration of the test compounds prior and after induction of colitis ameliorated the symptoms of colitis (diarrhea, presence of the blood in the stool) and delayed their onset. The ability of compounds 1 and 2 to reduce the levels of COX-2 and to increase the ratio of pro-MMP2/MMP2 activity correlates with the values of the DAI. The lowering of the levels of the antioxidant enzymes SOD2 and CAT reflects the ability of the test compounds to scavenge reactive oxygen species.
Citace poskytuje Crossref.org
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