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Evaluation of a DGP point-of-care test for celiac disease in a pediatric population
Claude-Olivier Marti, Benoit Fellay, Annemarie Bürgin-Wolff, Jean-Luc Magnin, Peter Baehler
Language English Country United States
- Keywords
- point-of-care test, detekce protilátek proti deamidovaným gliadin peptidům, pravidlo-out CD, rychlý test,
- MeSH
- Diet, Gluten-Free MeSH
- Biopsy MeSH
- Celiac Disease * diagnosis immunology complications prevention & control MeSH
- Diagnostic Techniques and Procedures * MeSH
- Child MeSH
- Data Interpretation, Statistical MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Predictive Value of Tests MeSH
- Child, Preschool MeSH
- Retrospective Studies MeSH
- Sensitivity and Specificity * MeSH
- Serologic Tests MeSH
- Statistics as Topic methods standards organization & administration MeSH
- Check Tag
- Child MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
Celiac disease (CD) is a largely undiagnosed immune-mediated enteropathy. A point-of-care test (POCT) could represent a rapid and cost-effective tool on ruling out CD. The objective of this study is to evaluate retrospectively the performance of a POCT based on detection of IgA and IgG antibodies against deamidated gliadins peptides (DGP). The study was performed on 53 children presenting clinical suspicions of CD, all being investigated by intestinal biopsy and standard serology. The performance of POCT was compared to the diagnostic result obtained from the gold standard of histology and serology. 10 children were diagnosed as CD positive by the POCT. Among the 43 children identified as CD negatives, 37 were correctly identified by POCT and 6 were considered as false positives. No false negative results were observed. The POCT yields a sensitivity and a negative predictive value (NPV) of 100%, and a negative likelihood ratio (LR-) of 0 in this selected pediatric population. The high NPV and low LR- ratio indicate that this POCT could be an useful and discriminative tool for excluding CD. This study and the results published so far are promising but need to be confirmed in larger cohort.
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Literatura
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