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Adipose Tissue as an Endocrine Organ: An Update on Pro-inflammatory and Anti-inflammatory Microenvironment
K. Smitka, D. Marešová
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Medline Complete (EBSCOhost) od 2012-01-01
ROAD: Directory of Open Access Scholarly Resources od 2013
Odkazy
PubMed
26093665
DOI
10.14712/23362936.2015.49
plný text volně přístupný
Knihovny.cz E-zdroje
- MeSH
- adipokiny fyziologie MeSH
- buněčné mikroprostředí fyziologie MeSH
- energetický metabolismus fyziologie MeSH
- energetický příjem fyziologie MeSH
- homeostáza fyziologie MeSH
- inzulinová rezistence fyziologie MeSH
- lidé MeSH
- tuková tkáň sekrece MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Adipose tissue is recognized as an active endocrine organ that produces a number of endocrine substances referred to as "adipokines" including leptin, adiponectin, adipolin, visfatin, omentin, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), resistin, pigment epithelium-derived factor (PEDF), and progranulin (PGRN) which play an important role in the food intake regulation and significantly influence insulin sensitivity and in some cases directly affect insulin resistance in skeletal muscle, liver, and adipose tissue. The review summarizes current knowledge about adipose tissue-derived hormones and their influence on energy homeostasis regulation. The possible therapeutic potential of these adipokines in the treatment of insulin resistance, endothelial dysfunction, a pro-inflammatory response, obesity, eating disorders, progression of atherosclerosis, type 1 diabetes, and type 2 diabetes is discussed.
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