• Je něco špatně v tomto záznamu ?

MKK7 and ARF: new players in the DNA damage response scenery

A. Kotsinas, P. Papanagnou, P. Galanos, D. Schramek, P. Townsend, JM. Penninger, J. Bartek, VG. Gorgoulis,

. 2014 ; 13 (8) : 1227-36. [pub] 20140326

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S.

Perzistentní odkaz   https://www.medvik.cz/link/bmc15032050
E-zdroje Online Plný text

NLK Free Medical Journals od 2002 do Před 1 rokem
PubMed Central od 2009 do Před 1 rokem
Europe PubMed Central od 2009 do Před 1 rokem

Odkazy

PubMed 24675893
DOI 10.4161/cc.28654
Knihovny.cz E-zdroje

Sensing, integrating, and processing of stressogenic signals must be followed by accurate differential response(s) for a cell to survive and avoid malignant transformation. The DNA damage response (DDR) pathway is vital in this process, as it deals with genotoxic/oncogenic insults, having p53 as a nodal effector that performs most of the above tasks. Accumulating data reveal that other pathways are also involved in the same or similar processes, conveying also to p53. Emerging questions are if, how, and when these additional pathways communicate with the DDR axis. Two such stress response pathways, involving the MKK7 stress-activated protein kinase (SAPK) and ARF, have been shown to be interlocked with the ATM/ATR-regulated DDR axis in a highly ordered manner. This creates a new landscape in the DDR orchestrated response to genotoxic/oncogenic insults that is currently discussed.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc15032050
003      
CZ-PrNML
005      
20151008130405.0
007      
ta
008      
151005s2014 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.4161/cc.28654 $2 doi
035    __
$a (PubMed)24675893
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Kotsinas, Athanassios $u Molecular Carcinogenesis Group; Department of Histology and Embryology; School of Medicine; University of Athens; Athens, Greece.
245    10
$a MKK7 and ARF: new players in the DNA damage response scenery / $c A. Kotsinas, P. Papanagnou, P. Galanos, D. Schramek, P. Townsend, JM. Penninger, J. Bartek, VG. Gorgoulis,
520    9_
$a Sensing, integrating, and processing of stressogenic signals must be followed by accurate differential response(s) for a cell to survive and avoid malignant transformation. The DNA damage response (DDR) pathway is vital in this process, as it deals with genotoxic/oncogenic insults, having p53 as a nodal effector that performs most of the above tasks. Accumulating data reveal that other pathways are also involved in the same or similar processes, conveying also to p53. Emerging questions are if, how, and when these additional pathways communicate with the DDR axis. Two such stress response pathways, involving the MKK7 stress-activated protein kinase (SAPK) and ARF, have been shown to be interlocked with the ATM/ATR-regulated DDR axis in a highly ordered manner. This creates a new landscape in the DDR orchestrated response to genotoxic/oncogenic insults that is currently discussed.
650    _2
$a zvířata $7 D000818
650    _2
$a ATM protein $x metabolismus $7 D064007
650    12
$a poškození DNA $7 D004249
650    12
$a oprava DNA $7 D004260
650    _2
$a lidé $7 D006801
650    _2
$a MAP kinasa-kinasa 7 $x metabolismus $7 D048688
650    _2
$a onkogeny $7 D009857
650    _2
$a fosforylace $7 D010766
650    12
$a čtecí rámce $7 D016364
650    _2
$a signální transdukce $7 D015398
650    _2
$a nádorový supresorový protein p53 $x metabolismus $7 D016159
650    _2
$a mitogenem aktivované proteinkinasy p38 $x metabolismus $7 D048051
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a Research Support, U.S. Gov't, Non-P.H.S. $7 D013486
700    1_
$a Papanagnou, Panagiota $u Molecular Carcinogenesis Group; Department of Histology and Embryology; School of Medicine; University of Athens; Athens, Greece.
700    1_
$a Galanos, Panagiotis $u Molecular Carcinogenesis Group; Department of Histology and Embryology; School of Medicine; University of Athens; Athens, Greece.
700    1_
$a Schramek, Daniel $u Howard Hughes Medical Institute; Laboratory of Mammalian Cell Biology and Development; The Rockefeller University; New York, NY USA.
700    1_
$a Townsend, Paul $u Faculty Institute of Cancer Sciences; University of Manchester; Manchester Academic Health Science Centre; Manchester, UK; Manchester Centre for Cellular Metabolism; University of Manchester; Manchester Academic Health Science Centre; Manchester, UK.
700    1_
$a Penninger, Josef M $u IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences; Vienna, Austria.
700    1_
$a Bartek, Jiri $u Danish Cancer Society Research Center; Copenhagen, Denmark; Institute of Molecular and Translational Medicine; Faculty of Medicine and Dentistry; Palacky University; Olomouc, Czech Republic.
700    1_
$a Gorgoulis, Vassilis G $u Molecular Carcinogenesis Group; Department of Histology and Embryology; School of Medicine; University of Athens; Athens, Greece; Faculty Institute of Cancer Sciences; University of Manchester; Manchester Academic Health Science Centre; Manchester, UK; Manchester Centre for Cellular Metabolism; University of Manchester; Manchester Academic Health Science Centre; Manchester, UK; Biomedical Research Foundation; Academy of Athens; Athens, Greece.
773    0_
$w MED00173232 $t Cell cycle (Georgetown, Tex.) $x 1551-4005 $g Roč. 13, č. 8 (2014), s. 1227-36
856    41
$u https://pubmed.ncbi.nlm.nih.gov/24675893 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20151005 $b ABA008
991    __
$a 20151008130551 $b ABA008
999    __
$a ok $b bmc $g 1092926 $s 915176
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 13 $c 8 $d 1227-36 $e 20140326 $i 1551-4005 $m Cell Cycle $n Cell Cycle $x MED00173232
LZP    __
$a Pubmed-20151005

Najít záznam

Citační ukazatele

Možnosti archivace