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Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results
EE. Aller, TM. Larsen, H. Claus, AK. Lindroos, A. Kafatos, A. Pfeiffer, JA. Martinez, T. Handjieva-Darlenska, M. Kunesova, S. Stender, WH. Saris, A. Astrup, MA. van Baak,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, multicentrická studie, randomizované kontrolované studie, práce podpořená grantem
NLK
Free Medical Journals
od 2005 do Před 5 lety
ProQuest Central
od 1997-02-01 do 2017-12-31
Open Access Digital Library
od 1997-01-01
Medline Complete (EBSCOhost)
od 2005-01-01 do 2015-11-30
Health & Medicine (ProQuest)
od 1997-02-01 do 2017-12-31
Psychology Database (ProQuest)
od 1997-02-01 do 2017-12-31
Public Health Database (ProQuest)
od 1997-02-01 do 2017-12-31
PubMed
24675714
DOI
10.1038/ijo.2014.52
Knihovny.cz E-zdroje
- MeSH
- adherence pacienta MeSH
- běloši * MeSH
- časové faktory MeSH
- dietní proteiny aplikace a dávkování MeSH
- dietní sacharidy aplikace a dávkování MeSH
- dospělí MeSH
- energetický příjem MeSH
- glukózový toleranční test MeSH
- glykemický index * MeSH
- hmotnostní přírůstek * MeSH
- hmotnostní úbytek * MeSH
- index tělesné hmotnosti MeSH
- kalorická restrikce MeSH
- lidé MeSH
- nízkoproteinová dieta MeSH
- obezita prevence a kontrola terapie MeSH
- obvod pasu MeSH
- redukční dieta * MeSH
- rodina MeSH
- tělesná hmotnost MeSH
- výživa - přehledy MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
- Geografické názvy
- Evropa MeSH
BACKGROUND: A high dietary protein (P) content and low glycemic index (LGI) have been suggested to be beneficial for weight management, but long-term studies are scarce. OBJECTIVE: The DIOGENES randomized clinical trial investigated the effect of P and GI on weight loss maintenance in overweight or obese adults in eight centers across Europe. This study reports the 1-year results in two of the centers that extended the intervention to 1 year. METHOD: After an 8-week low-calorie diet (LCD), 256 adults (body mass index >27 kg m(-)(2)) were randomized to five ad libitum diets for 12 months: high P/LGI (HP/LGI), HP/high GI (HP/HGI), low P/LGI (LP/LGI), LP/HGI and a control diet. During the first 6 months, foods were provided for free through a shop system and during the whole 12-month period, subjects received guidance by a dietician. Primary outcome variable was the change in body weight over the 12-month intervention period. RESULTS: During the LCD period, subjects lost 11.2 (10.8, 12.0) kg (mean (95% confidence interval (CI))). Average weight regain over the 12-month intervention period was 3.9 (95% CI 3.0-4.8) kg. Subjects on the HP diets regained less weight than subjects on the LP diets. The difference in weight regain after 1 year was 2.0 (0.4, 3.6) kg (P=0.017) (completers analysis, N=139) or 2.8 (1.4, 4.1) kg (P<0.001) (intention-to-treat analysis, N=256). No consistent effect of GI on weight regain was found. There were no clinically relevant differences in changes in cardiometabolic risk factors among diet groups. CONCLUSION: A higher protein content of an ad libitum diet improves weight loss maintenance in overweight and obese adults over 12 months.
Department of Clinical Biochemistry Gentofte University Hospital Hellerup Denmark
Institute of Preventive Medicine Centre for Health and Society Copenhagen Denmark
MRC Human Nutrition Research Elsie Widdowson Laboratory Cambridge UK
National Multiprofile Transport Hospital Sofia Bulgaria
Obesity Management Centre Institute of Endocrinology Prague Czech Republic
Citace poskytuje Crossref.org
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