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A genome-wide association study of anorexia nervosa
V. Boraska, CS. Franklin, JA. Floyd, LM. Thornton, LM. Huckins, L. Southam, NW. Rayner, I. Tachmazidou, KL. Klump, J. Treasure, CM. Lewis, U. Schmidt, F. Tozzi, K. Kiezebrink, J. Hebebrand, P. Gorwood, RA. Adan, MJ. Kas, A. Favaro, P....
Molecular psychiatry.
2014 ;
19 (10) :
1085-94.
[pub] 20140211
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc15032062
Grantová podpora
NT14094
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Zdroj
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Medline Complete (EBSCOhost)
od 1997-01-01 do 2015-12-31
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
24514567
DOI
10.1038/mp.2013.187
Knihovny.cz E-zdroje
- MeSH
- Asijci genetika MeSH
- běloši genetika MeSH
- celogenomová asociační studie MeSH
- jaderné proteiny genetika MeSH
- jednonukleotidový polymorfismus MeSH
- kalcineurin genetika MeSH
- kulinové proteiny genetika MeSH
- lidé MeSH
- mentální anorexie genetika MeSH
- metaanalýza jako téma MeSH
- studie případů a kontrol MeSH
- transportní proteiny genetika MeSH
- výměnné faktory guaninnukleotidů genetika MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Geografické názvy
- Japonsko MeSH
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.
] Genomics and Disease Group Centre for Genomic Regulation Barcelona Spain
1st Department of Psychiatry Athens University Medical School Athens Greece
Altrecht Eating Disorders Rintveld Zeist The Netherlands
Centre de Psychiatrie et Neurosciences Inserm U894 Paris France
Clinical Genetics Unit Department of Woman and Child Health University of Padova Padova Italy
CNRS 8090 Institute of Biology Pasteur Institute Lille France
Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno Czech Republic
Department of Child and Adolescent Psychiatry Institute of Psychiatry and Neurology Warsaw Poland
Department of Epidemiology Institute of Occupational Medicine Department of Epidemiology Lodz Poland
Department of Genetics The University of North Carolina at Chapel Hill Chapel Hill NC USA
Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden
Department of Medical Genetics University Medical Center Utrecht Utrecht The Netherlands
Department of Molecular Life Sciences Tokai University School of Medicine Kanagawa Japan
Department of Neurosciences University of Padova Padova Italy
Department of Nutrition and Dietetics Harokopio University Athens Greece
Department of Pediatrics 1st Faculty of Medicine Charles University Prague Czech Republic
Department of Psychiatry 1st Faculty of Medicine Charles University Prague Czech Republic
Department of Psychiatry and Psychotherapy Medical University of Vienna Vienna Austria
Department of Psychiatry McLean Hospital Harvard Medical School Belmont MA USA
Department of Psychiatry Poznan University of Medical Sciences Poznan Poland
Department of Psychiatry University of Naples SUN Naples Italy
Department of Psychiatry University of North Carolina at Chapel Hill Chapel Hill NC USA
Department of Psychiatry University of Pennsylvania Philadelphia PA USA
Department of Psychology Michigan State University East Lansing MI USA
Department of Psychology University of Oslo Oslo Norway
Department of Psychosomatic Research National Institute of Mental Health NCNP Tokyo Japan
Departments of Psychosocial and Internal Medicine Heidelberg University Heidelberg Germany
Eating Disorders Unit 1st Department of Psychiatry Athens University Medical School Athens Greece
Estonian Genome Center University of Tartu Tartu Estonia
Genetic Epidemiology Group International Agency for Research on Cancer Lyon France
Health Services Research Unit University of Aberdeen Aberdeen UK
Hjelt Institute University of Helsinki Helsinki Finland
INSERM U894 Centre of Psychiatry and Neuroscience Paris France
Institute of Clinical Molecular Biology University of Kiel Kiel Germany
Kartini Clinic Portland OR USA
Klinikum der Medizinischen Fakultät Martin Luther Universität Halle Wittenberg Halle Saale Germany
M Sklodowska Curie Cancer Center and Institute of Oncology Warsaw Poland
McGill University and Genome Quebec Innovation Centre Montreal QC Canada
Palacky University Olomouc Czech Republic
Parklandklinik Bad Wildungen Germany
Rheumatology Unit Department of Medicine at the Karolinska University Hospital Solna Sweden
Seattle University College of Nursing Seattle WA USA
Section of Eating Disorders Institute of Psychiatry King's College London London UK
The Center for Applied Genomics The Children's Hospital of Philadelphia Philadelphia PA USA
The Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden
Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton Cambridge UK
Citace poskytuje Crossref.org
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- $a Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- $a Clementi, M $u Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
- 700 1_
- $a Degortes, D $u Department of Neurosciences, University of Padova, Padova, Italy.
- 700 1_
- $a Forzan, M $u Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
- 700 1_
- $a Tenconi, E $u Department of Neurosciences, University of Padova, Padova, Italy.
- 700 1_
- $a Docampo, E $u 1] Genomics and Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Barcelona, Spain [3] Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain [4] Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
- 700 1_
- $a Escaramís, G $u 1] Genomics and Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Barcelona, Spain [3] Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain [4] Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
- 700 1_
- $a Jiménez-Murcia, S $u 1] Department of Psychiatry and CIBERON, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain [2] Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.
- 700 1_
- $a Lissowska, J $u M. Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.
- 700 1_
- $a Rajewski, A $u Department of Epidemiology, Institute of Occupational Medicine, Department of Epidemiology, Lodz, Poland.
- 700 1_
- $a Szeszenia-Dabrowska, N $u Department of Epidemiology, Institute of Occupational Medicine, Department of Epidemiology, Lodz, Poland.
- 700 1_
- $a Slopien, A $u Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
- 700 1_
- $a Hauser, J $u Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
- 700 1_
- $a Karhunen, L $u Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
- 700 1_
- $a Meulenbelt, I $u Molecular Epidemiology Section, Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands.
- 700 1_
- $a Slagboom, P E $u 1] Molecular Epidemiology Section, Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands [2] Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, Leiden, The Netherlands.
- 700 1_
- $a Tortorella, A $u Department of Psychiatry, University of Naples SUN, Naples, Italy.
- 700 1_
- $a Maj, M $u Department of Psychiatry, University of Naples SUN, Naples, Italy.
- 700 1_
- $a Dedoussis, G $u Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
- 700 1_
- $a Dikeos, D $u 1st Department of Psychiatry, Athens University Medical School, Athens, Greece.
- 700 1_
- $a Gonidakis, F $u Eating Disorders Unit, 1st Department of Psychiatry, Athens University Medical School, Athens, Greece.
- 700 1_
- $a Tziouvas, K $u Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
- 700 1_
- $a Tsitsika, A $u Adolescent Health Unit (A.H.U.), 2nd Department of Pediatrics - Medical School, University of Athens 'P. & A. Kyriakou' Children's Hospital, Athens, Greece.
- 700 1_
- $a Papezova, H $u Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
- 700 1_
- $a Slachtova, L $u Department of Pediatrics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
- 700 1_
- $a Martaskova, D $u Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
- 700 1_
- $a Kennedy, J L $u 1] Centre for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
- 700 1_
- $a Levitan, R D $u 1] Centre for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
- 700 1_
- $a Yilmaz, Z $u 1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Centre for Addiction and Mental Health, Toronto, ON, Canada.
- 700 1_
- $a Huemer, J $u Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Koubek, D $u Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Merl, E $u Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Wagner, G $u Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Lichtenstein, P $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Breen, G $u Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
- 700 1_
- $a Cohen-Woods, S $u Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
- 700 1_
- $a Farmer, A $u Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
- 700 1_
- $a McGuffin, P $u Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
- 700 1_
- $a Cichon, S $u 1] Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany [2] Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany [3] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
- 700 1_
- $a Giegling, I $u Klinikum der Medizinischen Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale, Germany.
- 700 1_
- $a Herms, S $u 1] Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany [2] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
- 700 1_
- $a Rujescu, D $u Klinikum der Medizinischen Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale, Germany.
- 700 1_
- $a Schreiber, S $u Institute of Clinical Molecular Biology, University of Kiel, Kiel, Germany.
- 700 1_
- $a Wichmann, H-E $u 1] Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany [2] Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany.
- 700 1_
- $a Dina, C $u CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France.
- 700 1_
- $a Sladek, R $u McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada.
- 700 1_
- $a Gambaro, G $u Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelly Hospitals, Catholic University, Rome, Italy.
- 700 1_
- $a Soranzo, N $u Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
- 700 1_
- $a Julia, A $u Unitat de Recerca de Reumatologia (URR), Institut de Recerca Hospital Universitari Vall d'Hebron, Barcelona, Spain.
- 700 1_
- $a Marsal, S $u Unitat de Recerca de Reumatologia (URR), Institut de Recerca Hospital Universitari Vall d'Hebron, Barcelona, Spain.
- 700 1_
- $a Rabionet, R $u 1] Genomics and Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Barcelona, Spain [3] Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain [4] Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
- 700 1_
- $a Gaborieau, V $u Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France.
- 700 1_
- $a Dick, D M $u Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
- 700 1_
- $a Palotie, A $u 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] The Finnish Institute of Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [3] The Program for Human and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 700 1_
- $a Ripatti, S $u 1] The Finnish Institute of Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Finnish Institute of Occupational Health, Helsinki, Finland.
- 700 1_
- $a Widén, E $u 1] The Finnish Institute of Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Finnish Institute of Occupational Health, Helsinki, Finland.
- 700 1_
- $a Andreassen, O A $u NORMENT, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
- 700 1_
- $a Espeseth, T $u 1] NORMENT, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway [2] Department of Psychology, University of Oslo, Oslo, Norway.
- 700 1_
- $a Lundervold, A $u 1] Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway [2] Kavli Research Centre for Aging and Dementia, Haraldsplass Deaconess Hospital, Bergen, Norway [3] K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
- 700 1_
- $a Reinvang, I $u Department of Psychology, University of Oslo, Oslo, Norway.
- 700 1_
- $a Steen, V M $u 1] Department of Clinical Science, K.G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), University of Bergen, Bergen, Norway [2] Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
- 700 1_
- $a Le Hellard, S $u 1] Department of Clinical Science, K.G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), University of Bergen, Bergen, Norway [2] Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
- 700 1_
- $a Mattingsdal, M $u NORMENT, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
- 700 1_
- $a Ntalla, I $u Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
- 700 1_
- $a Bencko, V $u Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
- 700 1_
- $a Foretova, L $u Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
- 700 1_
- $a Janout, V $u Palacky University, Olomouc, Czech Republic.
- 700 1_
- $a Navratilova, M $u Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
- 700 1_
- $a Gallinger, S $u 1] University Health Network, Toronto General Hospital, Toronto, ON, Canada [2] Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, ON, Canada.
- 700 1_
- $a Pinto, D $u Departments of Psychiatry, and Genetics and Genomic Sciences, Seaver Autism Center, and the Mindich Child Health and Development Institute, Mount Sinai School of Medicine, New York, NY, USA.
- 700 1_
- $a Scherer, S W $u The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
- 700 1_
- $a Aschauer, H $u Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Carlberg, L $u Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Schosser, A $u Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Alfredsson, L $u The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Ding, B $u The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Klareskog, L $u Rheumatology Unit, Department of Medicine at the Karolinska University Hospital, Solna, Sweden.
- 700 1_
- $a Padyukov, L $u Rheumatology Unit, Department of Medicine at the Karolinska University Hospital, Solna, Sweden.
- 700 1_
- $a Courtet, P $u 1] Inserm, U1061, Université Montpellier 1, Montpellier, France [2] Department of Emergency Psychiatry, CHU Montpellier, Montpellier, France.
- 700 1_
- $a Guillaume, S $u 1] Inserm, U1061, Université Montpellier 1, Montpellier, France [2] Department of Emergency Psychiatry, CHU Montpellier, Montpellier, France.
- 700 1_
- $a Jaussent, I $u 1] Inserm, U1061, Université Montpellier 1, Montpellier, France [2] Department of Emergency Psychiatry, CHU Montpellier, Montpellier, France.
- 700 1_
- $a Finan, C $u Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
- 700 1_
- $a Kalsi, G $u Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
- 700 1_
- $a Roberts, M $u Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
- 700 1_
- $a Logan, D W $u Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
- 700 1_
- $a Peltonen, L $u Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
- 700 1_
- $a Ritchie, G R S $u 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge.
- 700 1_
- $a Barrett, J C $u Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
- 700 1_
- $a ,
- 700 1_
- $a Estivill, X $u 1] Genomics and Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Barcelona, Spain [3] Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain [4] Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
- 700 1_
- $a Hinney, A $u Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Essen, University of Duisburg-Essen, Essen, Germany.
- 700 1_
- $a Sullivan, P F $u 1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- 700 1_
- $a Collier, D A $u 1] Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK [2] Eli Lilly and Company, Erl Wood Manor, Windlesham, UK.
- 700 1_
- $a Zeggini, E $u Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
- 700 1_
- $a Bulik, C M $u 1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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