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Invasive Candida infections in surgical patients in intensive care units: a prospective, multicentre survey initiated by the European Confederation of Medical Mycology (ECMM) (2006-2008)
L. Klingspor, AM. Tortorano, J. Peman, B. Willinger, P. Hamal, B. Sendid, A. Velegraki, C. Kibbler, JF. Meis, R. Sabino, M. Ruhnke, S. Arikan-Akdagli, J. Salonen, I. Dóczi,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, multicentrická studie, pozorovací studie, práce podpořená grantem
- MeSH
- antibiotická profylaxe MeSH
- antifungální látky terapeutické užití MeSH
- Candida * MeSH
- chirurgie operační statistika a číselné údaje MeSH
- dítě MeSH
- dospělí MeSH
- jednotky intenzivní péče statistika a číselné údaje MeSH
- kandidóza invazivní farmakoterapie epidemiologie prevence a kontrola MeSH
- kojenec MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- prospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- kojenec MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
A prospective, observational, multicentre study of invasive candidosis (IC) in surgical patients in intensive care units (ICUs) was conducted from 2006 to 2008 in 72 ICUs in 14 European countries. A total of 779 patients (62.5% males, median age 63 years) with IC were included. The median rate of candidaemia was 9 per 1000 admissions. In 10.8% the infection was already present at the time of admission to ICU. Candida albicans accounted for 54% of the isolates, followed by Candida parapsilosis 18.5%, Candida glabrata 13.8%, Candida tropicalis 6%, Candida krusei 2.5%, and other species 5.3%. Infections due to C. krusei (57.9%) and C. glabrata (43.6%) had the highest crude mortality rate. The most common preceding surgery was abdominal (51.5%), followed by thoracic (20%) and neurosurgery (8.2%). Candida glabrata was more often isolated after abdominal surgery in patients ≥60 years, and C. parapsilosis was more often isolated in neurosurgery and multiple trauma patients as well as children ≤1 year of age. The most common first-line treatment was fluconazole (60%), followed by caspofungin (18.7%), liposomal amphotericin B (13%), voriconazole (4.8%) and other drugs (3.5%). Mortality in surgical patients with IC in ICU was 38.8%. Multivariate analysis showed that factors independently associated with mortality were: patient age ≥60 years (hazard ratio (HR) 1.9, p 0.001), central venous catheter (HR 1.8, p 0.05), corticosteroids (HR 1.5, p 0.03), not receiving systemic antifungal treatment for IC (HR 2.8, p <0.0001), and not removing intravascular lines (HR 1.6, p 0.02).
Department of Clinical Microbiology La Fe University Hospital Valencia Spain
Department of Clinical Microbiology University of Szeged Szeged Hungary
Department of Medical Microbiology and Infectious Diseases Canisius Wilhelmina Hospital
Department of Medical Microbiology Hacettepe University Medical School Ankara Turkey
Department of Medicine Charité Universitätsmedizin Berlin Campus Charité Mitte Berlin Germany
Department of Medicine Päijät Häme Central Hospital Lahti Finland
Dipartimento Scienze Biomediche per la Salute Università degli Studi di Milano Milano Italy
Citace poskytuje Crossref.org
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