Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Impact of cognitive stimulation on ripples within human epileptic and non-epileptic hippocampus

M. Brázdil, J. Cimbálník, R. Roman, DJ. Shaw, MM. Stead, P. Daniel, P. Jurák, J. Halámek,

. 2015 ; 16 (-) : 47. [pub] 20150725

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16010032

BACKGROUND: Until now there has been no way of distinguishing between physiological and epileptic hippocampal ripples in intracranial recordings. In the present study we addressed this by investigating the effect of cognitive stimulation on interictal high frequency oscillations in the ripple range (80-250 Hz) within epileptic (EH) and non-epileptic hippocampus (NH). METHODS: We analyzed depth EEG recordings in 10 patients with intractable epilepsy, in whom hippocampal activity was recorded initially during quiet wakefulness and subsequently during a simple cognitive task. Using automated detection of ripples based on amplitude of the power envelope, we analyzed ripple rate (RR) in the cognitive and resting period, within EH and NH. RESULTS: Compared to quiet wakefulness we observed a significant reduction of RR during cognitive stimulation in EH, while it remained statistically marginal in NH. Further, we investigated the direct impact of cognitive stimuli on ripples (i.e. immediately post-stimulus), which showed a transient statistically significant suppression of ripples in the first second after stimuli onset in NH only. CONCLUSION: Our results point to a differential reactivity of ripples within EH and NH to cognitive stimulation.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16010032
003      
CZ-PrNML
005      
20160412122213.0
007      
ta
008      
160408s2015 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s12868-015-0184-0 $2 doi
024    7_
$a 10.1186/s12868-015-0184-0 $2 doi
035    __
$a (PubMed)26205426
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Brázdil, Milan $u Behavioural and Social Neuroscience Research Group, CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic. mbrazd@med.muni.cz. Department of Neurology, Brno Epilepsy Center, St. Anne's University Hospital and Medical Faculty of Masaryk University, Pekařská 53, Brno, 65691, Czech Republic. mbrazd@med.muni.cz.
245    10
$a Impact of cognitive stimulation on ripples within human epileptic and non-epileptic hippocampus / $c M. Brázdil, J. Cimbálník, R. Roman, DJ. Shaw, MM. Stead, P. Daniel, P. Jurák, J. Halámek,
520    9_
$a BACKGROUND: Until now there has been no way of distinguishing between physiological and epileptic hippocampal ripples in intracranial recordings. In the present study we addressed this by investigating the effect of cognitive stimulation on interictal high frequency oscillations in the ripple range (80-250 Hz) within epileptic (EH) and non-epileptic hippocampus (NH). METHODS: We analyzed depth EEG recordings in 10 patients with intractable epilepsy, in whom hippocampal activity was recorded initially during quiet wakefulness and subsequently during a simple cognitive task. Using automated detection of ripples based on amplitude of the power envelope, we analyzed ripple rate (RR) in the cognitive and resting period, within EH and NH. RESULTS: Compared to quiet wakefulness we observed a significant reduction of RR during cognitive stimulation in EH, while it remained statistically marginal in NH. Further, we investigated the direct impact of cognitive stimuli on ripples (i.e. immediately post-stimulus), which showed a transient statistically significant suppression of ripples in the first second after stimuli onset in NH only. CONCLUSION: Our results point to a differential reactivity of ripples within EH and NH to cognitive stimulation.
650    _2
$a dospělí $7 D000328
650    _2
$a kognice $x fyziologie $7 D003071
650    _2
$a implantované elektrody $7 D004567
650    _2
$a elektroencefalografie $7 D004569
650    _2
$a epilepsie $x patofyziologie $7 D004827
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a hipokampus $x patofyziologie $7 D006624
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a neuropsychologické testy $7 D009483
650    _2
$a rozpoznávání automatizované $7 D010363
650    _2
$a odpočinek $7 D012146
650    _2
$a zraková percepce $x fyziologie $7 D014796
650    _2
$a bdění $7 D014851
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Cimbálník, Jan $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic. jan.cimbalnik@fnusa.cz.
700    1_
$a Roman, Robert $u Behavioural and Social Neuroscience Research Group, CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic. roman@med.muni.cz. Department of Physiology, Medical Faculty of Masaryk University, Brno, Czech Republic. roman@med.muni.cz.
700    1_
$a Shaw, Daniel J $u Behavioural and Social Neuroscience Research Group, CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic. dan.shawj@gmail.com.
700    1_
$a Stead, Matt M $u Department of Neurology, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, MN, USA. stead.squire@mayo.edu.
700    1_
$a Daniel, Pavel $u Behavioural and Social Neuroscience Research Group, CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic. pdaniel@med.muni.cz. Department of Neurology, Brno Epilepsy Center, St. Anne's University Hospital and Medical Faculty of Masaryk University, Pekařská 53, Brno, 65691, Czech Republic. pdaniel@med.muni.cz.
700    1_
$a Jurák, Pavel $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic. jurak@isibrno.cz. Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic. jurak@isibrno.cz.
700    1_
$a Halámek, Josef $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic. josef@isibrno.cz. Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic. josef@isibrno.cz.
773    0_
$w MED00008196 $t BMC neuroscience $x 1471-2202 $g Roč. 16, č. - (2015), s. 47
856    41
$u https://pubmed.ncbi.nlm.nih.gov/26205426 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20160408 $b ABA008
991    __
$a 20160412122257 $b ABA008
999    __
$a ok $b bmc $g 1113461 $s 934400
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 16 $c - $d 47 $e 20150725 $i 1471-2202 $m BMC neuroscience $n BMC Neurosci $x MED00008196
LZP    __
$a Pubmed-20160408

Najít záznam

Citační ukazatele

Možnosti archivace