Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Serum Dickkopf-1 signaling and calcium deposition in aortic valve are significantly related to the presence of concomitant coronary atherosclerosis in patients with symptomatic calcified aortic stenosis

Z. Motovska, T. Vichova, M. Doktorova, M. Labos, M. Maly, P. Widimsky,

. 2015 ; 13 (-) : 63. [pub] 20150215

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16010308

Grantová podpora
NT13711 MZ0 CEP - Centrální evidence projektů

BACKGROUND: The study aimed to assess serum RANKL:OPG ratio, Dkk-1 and deposition of calcium in aortic valve in relation to the presence of concomitant coronary atherosclerosis in patients with symptomatic calcified aortic stenosis (CAS). METHODS: OPG, soluble RANKL and Dkk-1 were measured in 218 consecutive patients who were undergoing cardiac catheterization because of symptomatic CAS. Values of studied compounds were compared between patients without (Group A) and with (Group B) coronary atherosclerosis. Computed tomography derived Agatston score was assessed by using 256-slice CT. RESULTS: Presence of coronary atherosclerosis was related to significantly (p = 0.007) higher OPG and to significantly (p = 0.004) lower Dkk-1. Coronary atherosclerosis was also associated with a trend towards a decrease of RANKL. RANKL/OPG Ratios (mean (95% C.I.)) were: 20.04 (16.58; 24.23) in Group A and 12.69 (9.96; 16.17) in Group B, resp., p = 0.018). After adjustment, the difference in RANKL:OPG ratios was no longer significant. Multivariable regression underscored the significance of difference in Dkk-1 (pafter adjustement = 0.020). Group A patients had significantly higher Dkk-1, significantly higher deposition of calcium in aortic valve and were symptomatic in significantly younger age (p < 0.001) as compared to group B patients: Agatston score (mean (95% C.I.)) 4069.9 (3211.8; 5134.5) and 2413.5 (1821.3; 3198.1), p = 0.007. CONCLUSIONS: Dkk-1 and deposition of calcium in aortic valve differ significantly in relation to the presence/absence of coronary atherosclerosis in patients with symptomatic CAS. A positive association was found between Dkk-1 and calcium load in aortic valve in patients with symptomatic CAS and angiographically normal coronary arteries.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16010308
003      
CZ-PrNML
005      
20190923162502.0
007      
ta
008      
160408s2015 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s12967-015-0423-2 $2 doi
024    7_
$a 10.1186/s12967-015-0423-2 $2 doi
035    __
$a (PubMed)25889943
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Moťovská, Zuzana $u Cardiocentre, Third Medical Faculty Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic. zuzana.motovska@fnkv.cz. $7 xx0104795
245    10
$a Serum Dickkopf-1 signaling and calcium deposition in aortic valve are significantly related to the presence of concomitant coronary atherosclerosis in patients with symptomatic calcified aortic stenosis / $c Z. Motovska, T. Vichova, M. Doktorova, M. Labos, M. Maly, P. Widimsky,
520    9_
$a BACKGROUND: The study aimed to assess serum RANKL:OPG ratio, Dkk-1 and deposition of calcium in aortic valve in relation to the presence of concomitant coronary atherosclerosis in patients with symptomatic calcified aortic stenosis (CAS). METHODS: OPG, soluble RANKL and Dkk-1 were measured in 218 consecutive patients who were undergoing cardiac catheterization because of symptomatic CAS. Values of studied compounds were compared between patients without (Group A) and with (Group B) coronary atherosclerosis. Computed tomography derived Agatston score was assessed by using 256-slice CT. RESULTS: Presence of coronary atherosclerosis was related to significantly (p = 0.007) higher OPG and to significantly (p = 0.004) lower Dkk-1. Coronary atherosclerosis was also associated with a trend towards a decrease of RANKL. RANKL/OPG Ratios (mean (95% C.I.)) were: 20.04 (16.58; 24.23) in Group A and 12.69 (9.96; 16.17) in Group B, resp., p = 0.018). After adjustment, the difference in RANKL:OPG ratios was no longer significant. Multivariable regression underscored the significance of difference in Dkk-1 (pafter adjustement = 0.020). Group A patients had significantly higher Dkk-1, significantly higher deposition of calcium in aortic valve and were symptomatic in significantly younger age (p < 0.001) as compared to group B patients: Agatston score (mean (95% C.I.)) 4069.9 (3211.8; 5134.5) and 2413.5 (1821.3; 3198.1), p = 0.007. CONCLUSIONS: Dkk-1 and deposition of calcium in aortic valve differ significantly in relation to the presence/absence of coronary atherosclerosis in patients with symptomatic CAS. A positive association was found between Dkk-1 and calcium load in aortic valve in patients with symptomatic CAS and angiographically normal coronary arteries.
650    _2
$a senioři $7 D000368
650    _2
$a aortální chlopeň $x patologie $x radiografie $7 D001021
650    _2
$a aortální stenóza $x krev $x radiografie $7 D001024
650    _2
$a vývoj kostí $7 D001846
650    _2
$a kalcinóza $x krev $x radiografie $7 D002114
650    _2
$a vápník $x metabolismus $7 D002118
650    _2
$a nemoci koronárních tepen $x krev $x radiografie $7 D003324
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mezibuněčné signální peptidy a proteiny $x krev $7 D036341
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a biologické modely $7 D008954
650    _2
$a signální transdukce $7 D015398
650    _2
$a počítačová rentgenová tomografie $7 D014057
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Vichova, Teodora $u Cardiocentre, Third Medical Faculty Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic. teodora.vichova@fnkv.cz.
700    1_
$a Sionová, Magdalena $7 xx0236242 $u Cardiocentre, Third Medical Faculty Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic. magdalena.doktorova@fnkv.cz.
700    1_
$a Laboš, Marek $u Department, of Radiology, University Hospital Kralovske Vinohrady, Prague, Czech Republic. marek.labos@fnkv.cz. $7 xx0108108
700    1_
$a Malý, Marek $u National Institute of Public Health, Prague, Czech Republic. mmaly@szu.cz. $7 jn20001103265
700    1_
$a Widimský, Petr, $u Cardiocentre, Third Medical Faculty Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic. petr.widimsky@fnkv.cz. $d 1954- $7 jn20000402682
773    0_
$w MED00008239 $t Journal of translational medicine $x 1479-5876 $g Roč. 13, č. - (2015), s. 63
856    41
$u https://pubmed.ncbi.nlm.nih.gov/25889943 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20160408 $b ABA008
991    __
$a 20190923162859 $b ABA008
999    __
$a ok $b bmc $g 1113737 $s 934676
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 13 $c - $d 63 $e 20150215 $i 1479-5876 $m Journal of translational medicine $n J Transl Med $x MED00008239
GRA    __
$a NT13711 $p MZ0
LZP    __
$a Pubmed-20160408

Najít záznam

Citační ukazatele

Možnosti archivace