-
Je něco špatně v tomto záznamu ?
Irritable bowel syndrome: an integrated explanatory model for clinical practice
AP. Hungin, A. Becher, B. Cayley, JJ. Heidelbaugh, JW. Muris, G. Rubin, B. Seifert, A. Russell, NJ. De Wit,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
NLK
Medline Complete (EBSCOhost)
od 1998-12-01 do Před 1 rokem
Wiley Free Content
od 1997 do Před 18 měsíci
PubMed
25703486
DOI
10.1111/nmo.12524
Knihovny.cz E-zdroje
- MeSH
- dysbióza komplikace patofyziologie MeSH
- gastrointestinální trakt inervace patofyziologie sekrece MeSH
- genetická predispozice k nemoci MeSH
- lidé MeSH
- nervový přenos MeSH
- polymorfismus genetický MeSH
- psychický stres komplikace psychologie MeSH
- signální transdukce MeSH
- somatosenzorické poruchy komplikace patofyziologie MeSH
- střevní mikroflóra MeSH
- syndrom dráždivého tračníku etiologie patofyziologie psychologie MeSH
- vzdělávání pacientů jako téma * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
BACKGROUND: Although irritable bowel syndrome (IBS) is a symptom-based diagnosis, clinicians' management of and communication about the disorder is often hampered by an unclear conceptual understanding of the nature of the problem. We aimed to elucidate an integrated explanatory model (EM) for IBS from the existing literature for pragmatic use in the clinical setting. METHODS: Systematic and exploratory literature searches were performed in PubMed to identify publications on IBS and EMs. KEY RESULTS: The searches did not identify a single, integrated EM for IBS. However, three main hypotheses were elucidated that could provide components with which to develop an IBS EM: (i) altered peripheral regulation of gut function (including sensory and secretory mechanisms); (ii) altered brain-gut signaling (including visceral hypersensitivity); and (iii) psychological distress. Genetic polymorphisms and epigenetic changes may, to some degree, underlie the etiology and pathophysiology of IBS and could increase the susceptibility to developing the disorder. The three model components also fit into one integrated explanation for abdominal symptoms and changes in stool habit. Additionally, IBS may share a common pathophysiological mechanism with other associated functional syndromes. CONCLUSIONS & INFERENCES: It was possible to elucidate an integrated, three-component EM as a basis for clinicians to conceptualize the nature of IBS, with the potential to contribute to better diagnosis and management, and dialog with sufferers.
Department of Anthropology Durham University Durham UK
Department of Family Medicine University of Wisconsin Madison WI USA
Departments of Family Medicine and Urology Medical School University of Michigan Ann Arbor MI USA
Institute of General Practice Charles University Praha Czech Republic
School of Medicine Pharmacy and Health Durham University Stockton on Tees UK
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc16010530
- 003
- CZ-PrNML
- 005
- 20160415125146.0
- 007
- ta
- 008
- 160408s2015 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1111/nmo.12524 $2 doi
- 024 7_
- $a 10.1111/nmo.12524 $2 doi
- 035 __
- $a (PubMed)25703486
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Hungin, A P S $u School of Medicine, Pharmacy and Health, Durham University, Stockton-on-Tees, UK.
- 245 10
- $a Irritable bowel syndrome: an integrated explanatory model for clinical practice / $c AP. Hungin, A. Becher, B. Cayley, JJ. Heidelbaugh, JW. Muris, G. Rubin, B. Seifert, A. Russell, NJ. De Wit,
- 520 9_
- $a BACKGROUND: Although irritable bowel syndrome (IBS) is a symptom-based diagnosis, clinicians' management of and communication about the disorder is often hampered by an unclear conceptual understanding of the nature of the problem. We aimed to elucidate an integrated explanatory model (EM) for IBS from the existing literature for pragmatic use in the clinical setting. METHODS: Systematic and exploratory literature searches were performed in PubMed to identify publications on IBS and EMs. KEY RESULTS: The searches did not identify a single, integrated EM for IBS. However, three main hypotheses were elucidated that could provide components with which to develop an IBS EM: (i) altered peripheral regulation of gut function (including sensory and secretory mechanisms); (ii) altered brain-gut signaling (including visceral hypersensitivity); and (iii) psychological distress. Genetic polymorphisms and epigenetic changes may, to some degree, underlie the etiology and pathophysiology of IBS and could increase the susceptibility to developing the disorder. The three model components also fit into one integrated explanation for abdominal symptoms and changes in stool habit. Additionally, IBS may share a common pathophysiological mechanism with other associated functional syndromes. CONCLUSIONS & INFERENCES: It was possible to elucidate an integrated, three-component EM as a basis for clinicians to conceptualize the nature of IBS, with the potential to contribute to better diagnosis and management, and dialog with sufferers.
- 650 _2
- $a dysbióza $x komplikace $x patofyziologie $7 D064806
- 650 _2
- $a střevní mikroflóra $7 D000069196
- 650 _2
- $a gastrointestinální trakt $x inervace $x patofyziologie $x sekrece $7 D041981
- 650 _2
- $a genetická predispozice k nemoci $7 D020022
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a syndrom dráždivého tračníku $x etiologie $x patofyziologie $x psychologie $7 D043183
- 650 12
- $a vzdělávání pacientů jako téma $7 D010353
- 650 _2
- $a polymorfismus genetický $7 D011110
- 650 _2
- $a signální transdukce $7 D015398
- 650 _2
- $a somatosenzorické poruchy $x komplikace $x patofyziologie $7 D020886
- 650 _2
- $a psychický stres $x komplikace $x psychologie $7 D013315
- 650 _2
- $a nervový přenos $7 D009435
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Becher, A $u School of Medicine, Pharmacy and Health, Durham University, Stockton-on-Tees, UK. Research and Evaluation Unit, Oxford PharmaGenesis Ltd, Oxford, UK.
- 700 1_
- $a Cayley, B $u Department of Family Medicine, University of Wisconsin, Madison, WI, USA.
- 700 1_
- $a Heidelbaugh, J J $u Departments of Family Medicine and Urology, Medical School, University of Michigan, Ann Arbor, MI, USA.
- 700 1_
- $a Muris, J W M $u Department of Family Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.
- 700 1_
- $a Rubin, G $u School of Medicine, Pharmacy and Health, Durham University, Stockton-on-Tees, UK.
- 700 1_
- $a Seifert, B $u Institute of General Practice, Charles University, Praha, Czech Republic.
- 700 1_
- $a Russell, A $u Department of Anthropology, Durham University, Durham, UK.
- 700 1_
- $a De Wit, N J $u Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
- 773 0_
- $w MED00005047 $t Neurogastroenterology and motility $x 1365-2982 $g Roč. 27, č. 6 (2015), s. 750-63
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/25703486 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20160408 $b ABA008
- 991 __
- $a 20160415125231 $b ABA008
- 999 __
- $a ok $b bmc $g 1113959 $s 934898
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2015 $b 27 $c 6 $d 750-63 $e 20150220 $i 1365-2982 $m Neurogastroenterology and motility $n Neurogastroenterol Motil $x MED00005047
- LZP __
- $a Pubmed-20160408
