Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Diffusion tensor imaging in the characterization of multiple system atrophy

AM. Rulseh, J. Keller, J. Rusz, M. Syka, H. Brozova, R. Rusina, P. Havrankova, K. Zarubova, H. Malikova, R. Jech, J. Vymazal,

. 2016 ; 12 (-) : 2181-7. [pub] 20160826

Language English Country New Zealand

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc16027410

PURPOSE: Multiple system atrophy (MSA) is a rare neurodegenerative disease that remains poorly understood, and the diagnosis of MSA continues to be challenging. We endeavored to improve the diagnostic process and understanding of in vivo characteristics of MSA by diffusion tensor imaging (DTI). MATERIALS AND METHODS: Twenty MSA subjects, ten parkinsonian dominant (MSA-P), ten cerebellar dominant (MSA-C), and 20 healthy volunteer subjects were recruited. Fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity maps were processed using tract-based spatial statistics. Diffusion data were additionally evaluated in the basal ganglia. A support vector machine was used to assess diagnostic utility, leave-one-out cross-validation in the evaluation of classification schemes, and receiver operating characteristic analyses to determine cutoff values. RESULTS: We detected widespread changes in the brain white matter of MSA subjects; however, no group-wise differences were found between MSA-C and MSA-P subgroups. Altered DTI metrics in the putamen and middle cerebellar peduncles were associated with a positive parkinsonian and cerebellar phenotype, respectively. Concerning clinical applicability, we achieved high classification performance on mean diffusivity data in the combined bilateral putamen and middle cerebellar peduncle (accuracy 90.3%±9%, sensitivity 86.5%±11%, and specificity 99.3%±4%). CONCLUSION: DTI in the middle cerebellar peduncle and putamen may be used in the diagnosis of MSA with a high degree of accuracy.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16027410
003      
CZ-PrNML
005      
20200131104224.0
007      
ta
008      
161005s2016 nz f 000 0|eng||
009      
AR
024    7_
$a 10.2147/NDT.S109094 $2 doi
024    7_
$a 10.2147/NDT.S109094 $2 doi
035    __
$a (PubMed)27616888
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a nz
100    1_
$a Rulseh, Aaron Michael $7 xx0243723 $u Department of Radiology, Na Homolce Hospital, Prague, Czech Republic; Department of Radiology, 1st Faculty of Medicine, General University Hospital, Charles University in Prague, Prague, Czech Republic; National Institute of Mental Health, Klecany, Czech Republic
245    10
$a Diffusion tensor imaging in the characterization of multiple system atrophy / $c AM. Rulseh, J. Keller, J. Rusz, M. Syka, H. Brozova, R. Rusina, P. Havrankova, K. Zarubova, H. Malikova, R. Jech, J. Vymazal,
520    9_
$a PURPOSE: Multiple system atrophy (MSA) is a rare neurodegenerative disease that remains poorly understood, and the diagnosis of MSA continues to be challenging. We endeavored to improve the diagnostic process and understanding of in vivo characteristics of MSA by diffusion tensor imaging (DTI). MATERIALS AND METHODS: Twenty MSA subjects, ten parkinsonian dominant (MSA-P), ten cerebellar dominant (MSA-C), and 20 healthy volunteer subjects were recruited. Fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity maps were processed using tract-based spatial statistics. Diffusion data were additionally evaluated in the basal ganglia. A support vector machine was used to assess diagnostic utility, leave-one-out cross-validation in the evaluation of classification schemes, and receiver operating characteristic analyses to determine cutoff values. RESULTS: We detected widespread changes in the brain white matter of MSA subjects; however, no group-wise differences were found between MSA-C and MSA-P subgroups. Altered DTI metrics in the putamen and middle cerebellar peduncles were associated with a positive parkinsonian and cerebellar phenotype, respectively. Concerning clinical applicability, we achieved high classification performance on mean diffusivity data in the combined bilateral putamen and middle cerebellar peduncle (accuracy 90.3%±9%, sensitivity 86.5%±11%, and specificity 99.3%±4%). CONCLUSION: DTI in the middle cerebellar peduncle and putamen may be used in the diagnosis of MSA with a high degree of accuracy.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Keller, Jiri $u Department of Radiology, Na Homolce Hospital, Prague, Czech Republic; 3rd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
700    1_
$a Rusz, Jan $u Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
700    1_
$a Syka, Michael $u Department of Radiology, Na Homolce Hospital, Prague, Czech Republic.
700    1_
$a Brozova, Hana $u Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
700    1_
$a Rusina, Robert $u Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic; Thomayer Hospital, Prague, Czech Republic.
700    1_
$a Havrankova, Petra $u Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
700    1_
$a Zarubova, Katerina $u Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
700    1_
$a Malikova, Hana $u Department of Radiology, Na Homolce Hospital, Prague, Czech Republic.
700    1_
$a Jech, Robert $u Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
700    1_
$a Vymazal, Josef $u Department of Radiology, Na Homolce Hospital, Prague, Czech Republic.
773    0_
$w MED00183034 $t Neuropsychiatric disease and treatment $x 1176-6328 $g Roč. 12, č. - (2016), s. 2181-7
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27616888 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20161005 $b ABA008
991    __
$a 20200131104607 $b ABA008
999    __
$a ind $b bmc $g 1165724 $s 952040
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 12 $c - $d 2181-7 $e 20160826 $i 1176-6328 $m Neuropsychiatric disease and treatment $n Neuropsychiatr Dis Treat $x MED00183034
LZP    __
$a Pubmed-20161005

Find record

Citation metrics

Archiving options