Electroencephalography (EEG)-the direct recording of the electrical activity of populations of neurons-is a tremendously important tool for diagnosing, treating, and researching epilepsy. Although standard procedures for recording and analyzing human EEG exist and are broadly accepted, there are no such standards for research in animal models of seizures and epilepsy-recording montages, acquisition systems, and processing algorithms may differ substantially among investigators and laboratories. The lack of standard procedures for acquiring and analyzing EEG from animal models of epilepsy hinders the interpretation of experimental results and reduces the ability of the scientific community to efficiently translate new experimental findings into clinical practice. Accordingly, the intention of this report is twofold: (1) to review current techniques for the collection and software-based analysis of neural field recordings in animal models of epilepsy, and (2) to offer pertinent standards and reporting guidelines for this research. Specifically, we review current techniques for signal acquisition, signal conditioning, signal processing, data storage, and data sharing, and include applicable recommendations to standardize collection and reporting. We close with a discussion of challenges and future opportunities, and include a supplemental report of currently available acquisition systems and analysis tools. This work represents a collaboration on behalf of the American Epilepsy Society/International League Against Epilepsy (AES/ILAE) Translational Task Force (TASK1-Workgroup 5), and is part of a larger effort to harmonize video-EEG interpretation and analysis methods across studies using in vivo and in vitro seizure and epilepsy models.

Department of Epilepsy Movement Disorders and Physiology Graduate School of Medicine Kyoto University Kyoto Japan

Department of Neurology Baylor College of Medicine Houston Texas U S A

Department of Neurology Center for Neuroengineering and Therapeutics University of Pennsylvania Philadelphia Pennsylvania U S A

Department of Neurology Massachusetts General Hospital Harvard Medical School Boston Massachusetts U S A

Department of Neurosurgery National Nagasaki Medical Center Omura Nagasaki Japan

Departments of Neurology and Biomedical Engineering University of Michigan Ann Arbor Michigan U S A

Departments of Neurology Neurosurgery and Bioengineering Center for Neuroengineering and Therapeutics University of Pennsylvania Philadelphia Pennsylvania U S A

Institute of Physiology Czech Academy of Sciences Prague Czech Republic

IRCCS Foundation Epileptology and Experimental Neurophysiology Unit Carlo Besta Neurological Institute Milan Italy

Laboratory of Developmental Epilepsy Saul R Korey Department of Neurology Dominick P Purpura Department of Neuroscience Albert Einstein College of Medicine Bronx New York U S A

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