Electroencephalography (EEG) is commonly used in epilepsy and neuroscience research to study brain activity. The principles of EEG recording such as signal acquisition, digitization, and conditioning share similarities between animal and clinical EEG systems. In contrast, preclinical EEG studies demonstrate more variability and diversity than clinical studies in the types and locations of EEG electrodes, methods of data analysis, and scoring of EEG patterns and associated behaviors. The TASK3 EEG working group of the International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force has developed a set of preclinical common data elements (CDEs) and case report forms (CRFs) for recording, analysis, and scoring of animal EEG studies. This companion document accompanies the first set of proposed preclinical EEG CRFs and is intended to clarify the CDEs included in these worksheets. We provide 7 CRF and accompanying CDE modules for use by the research community, covering video acquisition, electrode information, experimental scheduling, and scoring of EEG activity. For ease of use, all data elements and input ranges are defined in supporting Excel charts (Appendix S1).

Department of Developmental Epileptology Institute of Physiology Czech Academy of Sciences Department of Neurology 2nd Faculty of Medicine Charles University and Motol University Hospital Prague Czech Republic

Department of Neurology Center for Neuroengineering and Therapeutics University of Pennsylvania Philadelphia Pennsylvania U S A

Department of Neurosurgery and Epilepsy Center Kagoshima University Hospital Kagoshima Japan

Department of Neurosurgery Epilepsy Center National Nagasaki Medical Center Omura Nagasaki Japan

Department of Pharmacology University of Oxford Oxford United Kingdom

Joint Translational Research Task Force of the ILAE AES ILAE West Hartford Connecticut U S A

Laboratory of Developmental Epilepsy Isabelle Rapin Division of Child Neurology Saul R Korey Department of Neurology Dominick P Purpura Department of Neuroscience Albert Einstein College of Medicine Montefiore Einstein Epilepsy Center Bronx New York U S A

Neurology Unit Epilepsy Center University Hospital University of Pisa Pisa Italy

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