Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Association Study for 26 Candidate Loci in Idiopathic Pulmonary Fibrosis Patients from Four European Populations

A. Kishore, V. Žižková, L. Kocourková, J. Petrkova, E. Bouros, H. Nunes, V. Loštáková, J. Müller-Quernheim, G. Zissel, V. Kolek, D. Bouros, D. Valeyre, M. Petrek,

. 2016 ; 7 (-) : 274. [pub] 20160711

Language English Country Switzerland

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc16027465

Idiopathic pulmonary fibrosis (IPF) affects lung parenchyma with progressing fibrosis. In this study, we aimed to replicate MUC5B rs35705950 variants and determine new plausible candidate variants for IPF among four different European populations. We genotyped 26 IPF candidate loci in 165 IPF patients from four European countries, such as Czech Republic (n = 41), Germany (n = 33), Greece (n = 40), France (n = 51), and performed association study comparing observed variant distribution with that obtained in a genetically similar Czech healthy control population (n = 96) described in our earlier data report. A highly significant association for a promoter variant (rs35705950) of mucin encoding MUC5B gene was observed in all IPF populations, individually and combined [odds ratio (95% confidence interval); p-value as 5.23 (8.94-3.06); 1.80 × 10(-11)]. Another non-coding variant, rs7934606 in MUC2 was significant among German patients [2.85 (5.05-1.60); 4.03 × 10(-4)] and combined European IPF cases [2.18 (3.16-1.50); 3.73 × 10(-5)]. The network analysis for these variants indicated gene-gene and gene-phenotype interactions in IPF and lung biology. With replication of MUC5B rs35705950 previously reported in U.S. populations of European descent and indicating other plausible polymorphic variants relevant for IPF, we provide additional reference information for future extended functional and population studies aimed, ideally with inclusion of clinical parameters, at identification of IPF genetic markers.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16027465
003      
CZ-PrNML
005      
20200429145444.0
007      
ta
008      
161005s2016 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3389/fimmu.2016.00274 $2 doi
024    7_
$a 10.3389/fimmu.2016.00274 $2 doi
035    __
$a (PubMed)27462317
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Kishore, Amit $u Laboratory of Immunogenomics, Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacký University , Olomouc , Czech Republic.
245    10
$a Association Study for 26 Candidate Loci in Idiopathic Pulmonary Fibrosis Patients from Four European Populations / $c A. Kishore, V. Žižková, L. Kocourková, J. Petrkova, E. Bouros, H. Nunes, V. Loštáková, J. Müller-Quernheim, G. Zissel, V. Kolek, D. Bouros, D. Valeyre, M. Petrek,
520    9_
$a Idiopathic pulmonary fibrosis (IPF) affects lung parenchyma with progressing fibrosis. In this study, we aimed to replicate MUC5B rs35705950 variants and determine new plausible candidate variants for IPF among four different European populations. We genotyped 26 IPF candidate loci in 165 IPF patients from four European countries, such as Czech Republic (n = 41), Germany (n = 33), Greece (n = 40), France (n = 51), and performed association study comparing observed variant distribution with that obtained in a genetically similar Czech healthy control population (n = 96) described in our earlier data report. A highly significant association for a promoter variant (rs35705950) of mucin encoding MUC5B gene was observed in all IPF populations, individually and combined [odds ratio (95% confidence interval); p-value as 5.23 (8.94-3.06); 1.80 × 10(-11)]. Another non-coding variant, rs7934606 in MUC2 was significant among German patients [2.85 (5.05-1.60); 4.03 × 10(-4)] and combined European IPF cases [2.18 (3.16-1.50); 3.73 × 10(-5)]. The network analysis for these variants indicated gene-gene and gene-phenotype interactions in IPF and lung biology. With replication of MUC5B rs35705950 previously reported in U.S. populations of European descent and indicating other plausible polymorphic variants relevant for IPF, we provide additional reference information for future extended functional and population studies aimed, ideally with inclusion of clinical parameters, at identification of IPF genetic markers.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Žižková, Veronika $u Laboratory of Immunogenomics, Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacký University , Olomouc , Czech Republic. $7 xx0209104
700    1_
$a Kocourková, Lenka $u Laboratory of Immunogenomics, Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacký University , Olomouc , Czech Republic.
700    1_
$a Petrkova, Jana $u Laboratory of Immunogenomics, Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacký University , Olomouc , Czech Republic.
700    1_
$a Bouros, Evangelos $u Laboratory of Pharmacology, University Hospital Alexandroupolis, Democritus University of Thrace , Athens , Greece.
700    1_
$a Nunes, Hilario $u Université Paris 13, COMUE Sorbonne Paris Cité, Bobigny , Paris , France.
700    1_
$a Lošťáková, Vladimíra, $d 1959- $u Department of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacký University , Olomouc , Czech Republic. $7 xx0042188
700    1_
$a Müller-Quernheim, Joachim $u Department of Pneumology, Center for Medicine, Medical Center, University of Freiburg , Freiburg , Germany.
700    1_
$a Zissel, Gernot $u Department of Pneumology, Center for Medicine, Medical Center, University of Freiburg , Freiburg , Germany.
700    1_
$a Kolek, Vitezslav $u Department of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacký University , Olomouc , Czech Republic.
700    1_
$a Bouros, Demosthenes $u Academic Department of Pneumonology, Hospital for Diseases of the Chest 'Sotiria', Medical School, University of Athens , Athens , Greece.
700    1_
$a Valeyre, Dominique $u Université Paris 13, COMUE Sorbonne Paris Cité, Bobigny , Paris , France.
700    1_
$a Petrek, Martin $u Laboratory of Immunogenomics, Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic; Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacký University and Faculty Hospital, Olomouc, Czech Republic.
773    0_
$w MED00181405 $t Frontiers in immunology $x 1664-3224 $g Roč. 7, č. - (2016), s. 274
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27462317 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20161005 $b ABA008
991    __
$a 20200429145439 $b ABA008
999    __
$a ind $b bmc $g 1165779 $s 952095
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 7 $c - $d 274 $e 20160711 $i 1664-3224 $m Frontiers in immunology $n Front Immunol $x MED00181405
LZP    __
$a Pubmed-20161005

Find record

Citation metrics

Archiving options