BACKGROUND: Small non-coding RNA molecules (miRs) are involved in immune cell maturation and function and might influence immunopathological processes of systemic lupus erythematosus (SLE) pathogenesis. METHODS AND RESULTS: This paper presents the results of a literature search for publications dealing with the relationship between miRs and pathological factors related to SLE such as genetic background, immune dysregulation and gender-associated differences participating in SLE development. In SLE, distinct miRs are differentially expressed in SLE cells of innate and adaptive immunity. The miR-146a and miR-155 genes, among others, interfere with intracellular signalling pathways downstream of toll-like receptors 7 and 9 (TLR- 7, TLR-9) and influences interferon (IFN)-type I synthesis in plasmacytoid dendritic cells. In T and B cells, miR-126, miR-21, miR-146a, miR-155, miR-1246 and others might influence gene expression by epigenetic modifications, support abnormal cytosine release, differentiation of cell subsets, B cell hyperactivity and autoantibody production. Besides, estrogen might up- and downregulate immunologically active miRs, which are potential mediators of hormonal influences in SLE development. Moreover, SLE genetic basis included some polymorphisms of the miR-146a gene, which varies across populations. CONCLUSION: Distinct miRs are differentially expressed in both SLE mice models and human patients and promote autoimmune features of immune processes. MiRs are important molecules modulating susceptibility to SLE as well as its onset, clinical diversity and progression.

Institute of Rheumatology Prague Czech Republic

000      

00000naa a2200000 a 4500

001      

bmc16028824

003      

CZ-PrNML

005      

20191126131015.0

007      

ta

008      

161005s2016 xr ad f 000 0|eng||

009      

AR

024    7_

$a 10.5507/bp.2016.004 $2 doi

035    __

$a (PubMed)27003314

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a xr

100    1_

$a Hušáková, Markéta $u Institute of Rheumatology, Prague, Czech Republic $7 xx0143346

245    10

$a MicroRNAs in the key events of systemic lupus erythematosus pathogenesis / $c M. Husakova

520    9_

$a BACKGROUND: Small non-coding RNA molecules (miRs) are involved in immune cell maturation and function and might influence immunopathological processes of systemic lupus erythematosus (SLE) pathogenesis. METHODS AND RESULTS: This paper presents the results of a literature search for publications dealing with the relationship between miRs and pathological factors related to SLE such as genetic background, immune dysregulation and gender-associated differences participating in SLE development. In SLE, distinct miRs are differentially expressed in SLE cells of innate and adaptive immunity. The miR-146a and miR-155 genes, among others, interfere with intracellular signalling pathways downstream of toll-like receptors 7 and 9 (TLR- 7, TLR-9) and influences interferon (IFN)-type I synthesis in plasmacytoid dendritic cells. In T and B cells, miR-126, miR-21, miR-146a, miR-155, miR-1246 and others might influence gene expression by epigenetic modifications, support abnormal cytosine release, differentiation of cell subsets, B cell hyperactivity and autoantibody production. Besides, estrogen might up- and downregulate immunologically active miRs, which are potential mediators of hormonal influences in SLE development. Moreover, SLE genetic basis included some polymorphisms of the miR-146a gene, which varies across populations. CONCLUSION: Distinct miRs are differentially expressed in both SLE mice models and human patients and promote autoimmune features of immune processes. MiRs are important molecules modulating susceptibility to SLE as well as its onset, clinical diversity and progression.

650    _2

$a adaptivní imunita $x fyziologie $7 D056704

650    _2

$a zvířata $7 D000818

650    _2

$a B-lymfocyty $x imunologie $7 D001402

650    _2

$a modely nemocí na zvířatech $7 D004195

650    _2

$a estrogeny $x fyziologie $7 D004967

650    _2

$a genetická predispozice k nemoci $7 D020022

650    _2

$a lidé $7 D006801

650    _2

$a přirozená imunita $x fyziologie $7 D007113

650    _2

$a systémový lupus erythematodes $x etiologie $x genetika $x imunologie $7 D008180

650    _2

$a myši $7 D051379

650    _2

$a mikro RNA $x genetika $x fyziologie $7 D035683

650    _2

$a jednonukleotidový polymorfismus $x genetika $7 D020641

650    _2

$a T-lymfocyty $x imunologie $7 D013601

655    _2

$a časopisecké články $7 D016428

655    _2

$a přehledy $7 D016454

773    0_

$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic $x 1213-8118 $g Roč. 160, č. 3 (2016), s. 327-342

856    41

$u http://biomed.papers.upol.cz/ $y Pubmed

910    __

$a ABA008 $b A 1502 $c 958 $y 4 $z 0

990    __

$a 20161005 $b ABA008

991    __

$a 20191126131301 $b ABA008

999    __

$a ok $b bmc $g 1169620 $s 953456

BAS    __

$a 3

BAS    __

$a PreBMC

BMC    __

$a 2016 $b 160 $c 3 $d 327-342 $e 20160321 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606

GRA    __

$a NT13707 $p MZ0

LZP    __

$b NLK118 $a Pubmed-20161005