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Synthesis, biological evaluation and molecular docking studies of 2-piperazin-1-yl-quinazolines as platelet aggregation inhibitors and ligands of integrin αIIbβ3

AA. Krysko, AY. Kornylov, PG. Polishchuk, GV. Samoylenko, OL. Krysko, TA. Kabanova, VCh. Kravtsov, VM. Kabanov, B. Wicher, SA. Andronati,

. 2016 ; 26 (7) : 1839-43. [pub] 20160222

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc17000411

A series of 2-piperazin-1-yl-quinazolines were synthesized and evaluated for their antiaggregative activity. The synthesized small molecule compounds have potently inhibited platelet aggregation in vitro and blocked FITC-Fg binding to αIIbβ3 integrin in a suspension of washed human platelets. The key αIIbβ3 protein-ligand interactions were determined in docking experiments and some correlations have been observed between values of the affinity and docking scores.

Citace poskytuje Crossref.org

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