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Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
V. Silvestri, D. Barrowdale, AM. Mulligan, SL. Neuhausen, S. Fox, BY. Karlan, G. Mitchell, P. James, DL. Thull, KK. Zorn, NJ. Carter, KL. Nathanson, SM. Domchek, TR. Rebbeck, SJ. Ramus, RL. Nussbaum, OI. Olopade, J. Rantala, SY. Yoon, MA. Caligo,...
Language English Country England, Great Britain
Document type Journal Article
NLK
BioMedCentral
from 1999-12-01
BioMedCentral Open Access
from 1999
Directory of Open Access Journals
from 2000
Free Medical Journals
from 1999 to 2 years ago
PubMed Central
from 1999
Europe PubMed Central
from 1999
ProQuest Central
from 2015-01-01
Open Access Digital Library
from 1999-01-01
Open Access Digital Library
from 1999-07-01
Open Access Digital Library
from 2000-01-01
Health & Medicine (ProQuest)
from 2015-01-01
ROAD: Directory of Open Access Scholarly Resources
from 1999
Springer Nature OA/Free Journals
from 1999-12-01
- MeSH
- Adult MeSH
- Genetic Predisposition to Disease MeSH
- Polymorphism, Single Nucleotide MeSH
- Middle Aged MeSH
- Humans MeSH
- Mutation MeSH
- Breast Neoplasms, Male genetics pathology MeSH
- Breast Neoplasms genetics pathology MeSH
- BRCA1 Protein genetics MeSH
- BRCA2 Protein genetics MeSH
- Aged MeSH
- Neoplasm Staging MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
BACKGROUND: BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs). METHODS: We characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (SEER) database. RESULTS: Among BRCA2 MBCs, grade significantly decreased with increasing age at diagnosis (P = 0.005). Compared with BRCA2 FBCs, BRCA2 MBCs were of significantly higher stage (P for trend = 2 × 10(-5)) and higher grade (P for trend = 0.005) and were more likely to be oestrogen receptor-positive [odds ratio (OR) 10.59; 95 % confidence interval (CI) 5.15-21.80] and progesterone receptor-positive (OR 5.04; 95 % CI 3.17-8.04). With the exception of grade, similar patterns of associations emerged when we compared BRCA1 MBCs and FBCs. BRCA2 MBCs also presented with higher grade than MBCs from the SEER database (P for trend = 4 × 10(-12)). CONCLUSIONS: On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs, and we identified a specific BRCA2-associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management.
Biomedical Network on Rare Diseases Madrid Spain
Cancer Division QIMR Berghofer Medical Research Institute Brisbane Australia
Cancer Risk and Prevention Clinic Dana Farber Cancer Institute Boston MA USA
Center for Genomic Medicine Rigshospitalet Copenhagen University Hospital Copenhagen Denmark
Center for Medical Genetics Ghent University Ghent Belgium
Center for Medical Genetics North Shore University Health System Evanston IL USA
Clinical Genetics Guy's and St Thomas' NHS Foundation Trust London UK
Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno Czech Republic
Department of Clinical Genetics Aarhus University Hospital Aarhus N Denmark
Department of Clinical Genetics Fox Chase Cancer Center Philadelphia PA USA
Department of Clinical Genetics Karolinska University Hospital Stockholm Sweden
Department of Clinical Genetics Odense University Hospital Odense C Denmark
Department of Clinical Genetics Rigshospitalet Copenhagen University Hospital Copenhagen Denmark
Department of Clinical Genetics Vejle Hospital Vejle Denmark
Department of Epidemiology Cancer Prevention Institute of California Fremont CA USA
Department of Epidemiology Mailman School of Public Health Columbia University New York NY USA
Department of Genetics and Pathology Pomeranian Medical University Szczecin Poland
Department of Genetics Portuguese Institute of Oncology Porto Portugal
Department of Gynaecology and Obstetrics Technical University of Munich Munich Germany
Department of Gynecology and Obstetrics Technical University of Dresden Dresden Germany
Department of Health Sciences Research Mayo Clinic Rochester MN USA
Department of Hematology and Oncology University of Kansas Medical Center Kansas City KS USA
Department of Medical Oncology Beth Israel Deaconess Medical Center Boston MA USA
Department of Medical Oncology Vall d'Hebron University Hospital Barcelona Spain
Department of Medicine and Genetics University of California San Francisco San Francisco CA USA
Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA
Department of Molecular Genetics National Institute of Oncology Budapest Hungary
Department of Molecular Medicine Sapienza University of Rome Viale Regina Elena 324 00161 Rome Italy
Department of Oncology and Haematology University of Modena and Reggio Emilia Modena Italy
Department of Oncology Mayo Clinic Rochester MN USA
Department of Oncology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark
Department of Pathology National Institute of Oncology Budapest Hungary
Department of Population Sciences Beckman Research Institute of City of Hope Duarte CA USA
Department of Surgery Daerim St Mary's Hospital Seoul Korea
Department of Tumour Biology Institut Curie Paris France
Department of Urology Medical University of Vienna Vienna Austria
Division of Cancer Prevention and Genetics European Institute of Oncology Milan Italy
Division of Experimental Oncology CRO Aviano National Cancer Institute Aviano PN Italy
Genetic Epidemiology Laboratory Department of Pathology University of Melbourne Parkville Australia
Hannover Medical School Hannover Germany
Human Genetics Group Human Cancer Genetics Program Spanish National Cancer Centre Madrid Spain
IFOM FIRC Institute of Molecular Oncology Milan Italy
Immunology and Molecular Oncology Unit Veneto Institute of Oncology IOV IRCCS Padua Italy
INSERM U1052 CNRS UMR5286 Centre de Recherche en Cancérologie de Lyon Université Lyon Lyon France
Institute for Medical Informatics Statistics and Epidemiology University of Leipzig Leipzig Germany
Institute of Human Genetics Charité Berlin Germany
Institute of Human Genetics Leipzig Germany
Institute of Human Genetics University Hospital Heidelberg Heidelberg Germany
Institute of Human Genetics University of Wurzburg Wurzburg Germany
Lombardi Comprehensive Cancer Center Georgetown University Washington DC USA
Lunenfeld Tanenbaum Research Institute Mount Sinai Hospital Toronto ON Canada
Masaryk Memorial Cancer Institute and Faculty of Medicine Masaryk University Brno Czech Republic
Molecular and Nutritional Epidemiology Unit Cancer Research and Prevention Institute Florence Italy
Molecular Genetics of Breast Cancer German Cancer Research Center Heidelberg Germany
N N Petrov Institute of Oncology St Petersburg Russia
National Cancer Institute Giovanni Paolo 2 Bari Italy
Oncogenetics Team The Institute of Cancer Research and Royal Marsden NHS Foundation Trust Sutton UK
Peter MacCallum Cancer Institute East Melbourne Australia
State Research Institute Centre for Innovative Medicine Vilnius Lithuania
Unit of Medical Genetics Department of Preventive and Predictive Medicine IRCCS Milan Italy
University of Dusseldorf Dusseldorf Germany
University of Pittsburgh School of Medicine Pittsburgh PA USA
References provided by Crossref.org
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- $a Silvestri, Valentina $u Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy. valentina.silvestri@uniroma1.it.
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- $a Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 / $c V. Silvestri, D. Barrowdale, AM. Mulligan, SL. Neuhausen, S. Fox, BY. Karlan, G. Mitchell, P. James, DL. Thull, KK. Zorn, NJ. Carter, KL. Nathanson, SM. Domchek, TR. Rebbeck, SJ. Ramus, RL. Nussbaum, OI. Olopade, J. Rantala, SY. Yoon, MA. Caligo, L. Spugnesi, A. Bojesen, IS. Pedersen, M. Thomassen, UB. Jensen, AE. Toland, L. Senter, IL. Andrulis, G. Glendon, PJ. Hulick, EN. Imyanitov, MH. Greene, PL. Mai, CF. Singer, C. Rappaport-Fuerhauser, G. Kramer, J. Vijai, K. Offit, M. Robson, A. Lincoln, L. Jacobs, E. Machackova, L. Foretova, M. Navratilova, P. Vasickova, FJ. Couch, E. Hallberg, KJ. Ruddy, P. Sharma, SW. Kim, . , MR. Teixeira, P. Pinto, M. Montagna, L. Matricardi, A. Arason, OT. Johannsson, RB. Barkardottir, A. Jakubowska, J. Lubinski, A. Izquierdo, MA. Pujana, J. Balmaña, O. Diez, G. Ivady, J. Papp, E. Olah, A. Kwong, . , H. Nevanlinna, K. Aittomäki, P. Perez Segura, T. Caldes, T. Van Maerken, B. Poppe, KB. Claes, C. Isaacs, C. Elan, C. Lasset, D. Stoppa-Lyonnet, L. Barjhoux, M. Belotti, A. Meindl, A. Gehrig, C. Sutter, C. Engel, D. Niederacher, D. Steinemann, E. Hahnen, K. Kast, N. Arnold, R. Varon-Mateeva, D. Wand, AK. Godwin, DG. Evans, D. Frost, J. Perkins, J. Adlard, L. Izatt, R. Platte, R. Eeles, S. Ellis, . , U. Hamann, J. Garber, F. Fostira, G. Fountzilas, B. Pasini, G. Giannini, P. Rizzolo, A. Russo, L. Cortesi, L. Papi, L. Varesco, D. Palli, I. Zanna, A. Savarese, P. Radice, S. Manoukian, B. Peissel, M. Barile, B. Bonanni, A. Viel, V. Pensotti, S. Tommasi, P. Peterlongo, JN. Weitzel, A. Osorio, J. Benitez, L. McGuffog, S. Healey, AM. Gerdes, B. Ejlertsen, TV. Hansen, L. Steele, YC. Ding, N. Tung, R. Janavicius, DE. Goldgar, SS. Buys, MB. Daly, A. Bane, MB. Terry, EM. John, M. Southey, DF. Easton, G. Chenevix-Trench, AC. Antoniou, L. Ottini,
- 520 9_
- $a BACKGROUND: BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs). METHODS: We characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (SEER) database. RESULTS: Among BRCA2 MBCs, grade significantly decreased with increasing age at diagnosis (P = 0.005). Compared with BRCA2 FBCs, BRCA2 MBCs were of significantly higher stage (P for trend = 2 × 10(-5)) and higher grade (P for trend = 0.005) and were more likely to be oestrogen receptor-positive [odds ratio (OR) 10.59; 95 % confidence interval (CI) 5.15-21.80] and progesterone receptor-positive (OR 5.04; 95 % CI 3.17-8.04). With the exception of grade, similar patterns of associations emerged when we compared BRCA1 MBCs and FBCs. BRCA2 MBCs also presented with higher grade than MBCs from the SEER database (P for trend = 4 × 10(-12)). CONCLUSIONS: On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs, and we identified a specific BRCA2-associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management.
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- $a Barrowdale, Daniel $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. daniel@srl.cam.ac.uk.
- 700 1_
- $a Mulligan, Anna Marie $u Laboratory Medicine Program, University Health Network, Toronto, ON, Canada. annamarie.mulligan@uhn.ca. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. annamarie.mulligan@uhn.ca.
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- $a Neuhausen, Susan L $u Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA. sneuhausen@coh.org.
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- 700 1_
- $a James, Paul $u Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Australia. paul.james@petermac.org. Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia. paul.james@petermac.org.
- 700 1_
- $a Thull, Darcy L $u University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. dthull@magee.edu.
- 700 1_
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- 700 1_
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- 700 1_
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- $a Nussbaum, Robert L $u Department of Medicine and Genetics, University of California, San Francisco, San Francisco, CA, USA. nussbaumr@humgen.ucsf.edu.
- 700 1_
- $a Olopade, Olufunmilayo I $u Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, IL, USA. folopade@medicine.bsd.uchicago.edu.
- 700 1_
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- 700 1_
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- 700 1_
- $a Caligo, Maria A $u Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy. adelaide.caligo@do.unipi.it.
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- $a Spugnesi, Laura $u Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy. laura.spugnesi@gmail.com.
- 700 1_
- $a Bojesen, Anders $u Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark. anders.bojesen@slb.regionsyddanmark.dk.
- 700 1_
- $a Pedersen, Inge Sokilde $u Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Aalborg, Denmark. isp@rn.dk.
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- $a Thomassen, Mads $u Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark. mads.thomassen@rsyd.dk.
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- $a Jensen, Uffe Birk $u Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark. uffejens@rm.dk.
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Imyanitov, Evgeny N $u N.N. Petrov Institute of Oncology, St. Petersburg, Russia. evgeny@imyanitov.spb.ru.
- 700 1_
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- 700 1_
- $a Singer, Christian F $u Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. christian.singer@meduniwien.ac.at.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a ,
- 700 1_
- $a Teixeira, Manuel R $u Department of Genetics, Portuguese Institute of Oncology, Porto, Portugal. manuel.teixeira@ipoporto.min-saude.pt. Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal. manuel.teixeira@ipoporto.min-saude.pt.
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Ivady, Gabriella $u Department of Pathology, National Institute of Oncology, Budapest, Hungary. ivadygabi@oncol.hu.
- 700 1_
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- 700 1_
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- 700 1_
- $a Kwong, Ava $u The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, China. akwong@asiabreastregistry.com. Department of Surgery, The University of Hong Kong, Hong Kong, China. akwong@asiabreastregistry.com.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Elan, Camille $u Department of Tumour Biology, Institut Curie, Paris, France. camille.elan@curie.net.
- 700 1_
- $a Lasset, Christine $u CNRS UMR5558, Université Lyon 1, Lyon, France. christine.lasset@lyon.unicancer.fr. Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France. christine.lasset@lyon.unicancer.fr.
- 700 1_
- $a Stoppa-Lyonnet, Dominique $u Department of Tumour Biology, Institut Curie, Paris, France. dominique.stoppa-lyonnet@curie.net. Université Paris Descartes, Sorbonne Paris Cité, Paris, France. dominique.stoppa-lyonnet@curie.net.
- 700 1_
- $a Barjhoux, Laure $u INSERM U1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Université Lyon, Lyon, France. laure.barjhoux@lyon.unicancer.fr.
- 700 1_
- $a Belotti, Muriel $u Department of Tumour Biology, Institut Curie, Paris, France. muriel.belotti@curie.net.
- 700 1_
- $a Meindl, Alfons $u Department of Gynaecology and Obstetrics, Technical University of Munich, Munich, Germany. alfons.meindl@lrz.tu-muenchen.de.
- 700 1_
- $a Gehrig, Andrea $u Institute of Human Genetics, University of Wurzburg, Wurzburg, Germany. gehrig@biozentrum.uni-wuerzburg.de.
- 700 1_
- $a Sutter, Christian $u Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany. c.sutter@med.uni-heidelberg.de.
- 700 1_
- $a Engel, Christoph $u Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig, Leipzig, Germany. christoph.engel@imise.uni-leipzig.de.
- 700 1_
- $a Niederacher, Dieter $u University of Dusseldorf, Dusseldorf, Germany. niederac@uni-duesseldorf.de.
- 700 1_
- $a Steinemann, Doris $u Hannover Medical School, Hannover, Germany. steinemann.doris@mh-hannover.de.
- 700 1_
- $a Hahnen, Eric $u Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany. eric.hahnen@uk-koeln.de.
- 700 1_
- $a Kast, Karin $u Department of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany. karin.kast@uniklinikum-dresden.de.
- 700 1_
- $a Arnold, Norbert $u Department of Gynaecolgy and Obstetrics, University Hospital of Schleswig-Holstein, Christian-Albrechts-University of Kiel, Kiel, Germany. norbert.arnold@uksh.de.
- 700 1_
- $a Varon-Mateeva, Raymonda $u Institute of Human Genetics, Charité, Berlin, Germany. raymonda.varon-mateeva@charite.de.
- 700 1_
- $a Wand, Dorothea $u Institute of Human Genetics, Leipzig, Germany. dorothea.wand@medizin.uni-leipzig.de.
- 700 1_
- $a Godwin, Andrew K $u Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA. agodwin@kumc.edu.
- 700 1_
- $a Evans, D Gareth $u Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK. gareth.evans@cmft.nhs.uk.
- 700 1_
- $a Frost, Debra $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. djsf2@medschl.cam.ac.uk.
- 700 1_
- $a Perkins, Jo $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. jp410@medschl.cam.ac.uk.
- 700 1_
- $a Adlard, Julian $u Yorkshire Regional Genetics Service, Leeds, UK. julian.adlard@leedsth.nhs.uk.
- 700 1_
- $a Izatt, Louise $u Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, UK. louise.izatt@gstt.nhs.uk.
- 700 1_
- $a Platte, Radka $u Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK. rp356@medschl.cam.ac.uk.
- 700 1_
- $a Eeles, Ros $u Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. rosalind.eeles@icr.ac.uk.
- 700 1_
- $a Ellis, Steve $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. steve@srl.cam.ac.uk.
- 700 1_
- $a ,
- 700 1_
- $a Hamann, Ute $u Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. u.hamann@dkfz-heidelberg.de.
- 700 1_
- $a Garber, Judy $u Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA, USA. judy_garber@dfci.harvard.edu.
- 700 1_
- $a Fostira, Florentia $u Molecular Diagnostics Laboratory, Institute of Nuclear and Radiological Sciences and Technology (INRASTES), National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis, Athens, Greece. florentia@rrp.demokritos.gr.
- 700 1_
- $a Fountzilas, George $u Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece. fountzil@auth.gr.
- 700 1_
- $a Pasini, Barbara $u Department of Medical Science, University of Turin, Turin, Italy. barbara.pasini@unito.it. AO Città della Salute e della Scienza, Turin, Italy. barbara.pasini@unito.it.
- 700 1_
- $a Giannini, Giuseppe $u Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy. giuseppe.giannini@uniroma1.it.
- 700 1_
- $a Rizzolo, Piera $u Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy. piera.rizzolo@uniroma1.it.
- 700 1_
- $a Russo, Antonio $u Section of Medical Oncology, Department of Surgical and Oncological Sciences, University of Palermo, Palermo, Italy. lab-oncobiologia@usa.net.
- 700 1_
- $a Cortesi, Laura $u Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy. hbc@unimore.it.
- 700 1_
- $a Papi, Laura $u Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy. laura.papi@unifi.it.
- 700 1_
- $a Varesco, Liliana $u Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Scientific Institute of Hospitalization and Care), AOU San Martino - IST National Institute for Cancer Research, Genoa, Italy. liliana.varesco@hsanmartino.it.
- 700 1_
- $a Palli, Domenico $u Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy. d.palli@ispo.toscana.it.
- 700 1_
- $a Zanna, Ines $u Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy. i.zanna@ispo.toscana.it.
- 700 1_
- $a Savarese, Antonella $u Unit of Genetic Counselling, Medical Oncology Department, Regina Elena National Cancer Institute, Rome, Italy. savarese@ifo.it.
- 700 1_
- $a Radice, Paolo $u Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, IRCCS (Scientific Institute of Hospitalization and Care), National Cancer Institute (INT), 20133, Milan, Italy. paolo.radice@istitutotumori.mi.it.
- 700 1_
- $a Manoukian, Siranoush $u Unit of Medical Genetics, Department of Preventive and Predictive Medicine, IRCCS (Scientific Institute of Hospitalization and Care), National Cancer Institute (INT), Milan, Italy. siranoush.manoukian@istitutotumori.mi.it.
- 700 1_
- $a Peissel, Bernard $u Unit of Medical Genetics, Department of Preventive and Predictive Medicine, IRCCS (Scientific Institute of Hospitalization and Care), National Cancer Institute (INT), Milan, Italy. bernard.peissel@istitutotumori.mi.it.
- 700 1_
- $a Barile, Monica $u Division of Cancer Prevention and Genetics, European Institute of Oncology (IEO), Milan, Italy. monica.barile@ieo.it.
- 700 1_
- $a Bonanni, Bernardo $u Division of Cancer Prevention and Genetics, European Institute of Oncology (IEO), Milan, Italy. bernardo.bonanni@ieo.it.
- 700 1_
- $a Viel, Alessandra $u Division of Experimental Oncology, CRO Aviano National Cancer Institute, Aviano, PN, Italy. aviel@cro.it.
- 700 1_
- $a Pensotti, Valeria $u IFOM, FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy. valeria.pensotti@ifom.eu. Cogentech Cancer Genetic Test Laboratory, Milan, Italy. valeria.pensotti@ifom.eu.
- 700 1_
- $a Tommasi, Stefania $u National Cancer Institute "Giovanni Paolo II", Bari, Italy. s.tommasi@oncologico.bari.it.
- 700 1_
- $a Peterlongo, Paolo $u IFOM, FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy. paolo.peterlongo@ifom.eu.
- 700 1_
- $a Weitzel, Jeffrey N $u Clinical Cancer Genetics, City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA. jweitzel@coh.org.
- 700 1_
- $a Osorio, Ana $u Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain. aosorio@cnio.es. Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. aosorio@cnio.es.
- 700 1_
- $a Benitez, Javier $u Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. jbenitez@cnio.es. Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain. jbenitez@cnio.es. Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. jbenitez@cnio.es.
- 700 1_
- $a McGuffog, Lesley $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. lesley@srl.cam.ac.uk.
- 700 1_
- $a Healey, Sue $u Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia. sue.healey@qimrberghofer.edu.au.
- 700 1_
- $a Gerdes, Anne-Marie $u Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. anne-marie.gerdes@regionh.dk.
- 700 1_
- $a Ejlertsen, Bent $u Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. bent.ejlertsen@regionh.dk.
- 700 1_
- $a Hansen, Thomas V O $u Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. tvoh@rh.dk.
- 700 1_
- $a Steele, Linda $u Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA. lsteele@coh.org.
- 700 1_
- $a Ding, Yuan Chun $u Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA. ycding@coh.org.
- 700 1_
- $a Tung, Nadine $u Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA. ntung@bidmc.harvard.edu.
- 700 1_
- $a Janavicius, Ramunas $u State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania. ramunas.janavicius@santa.lt.
- 700 1_
- $a Goldgar, David E $u Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. david.goldgar@hsc.utah.edu.
- 700 1_
- $a Buys, Saundra S $u Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. saundra.buys@hci.utah.edu.
- 700 1_
- $a Daly, Mary B $u Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA. mary.daly@fccc.edu.
- 700 1_
- $a Bane, Anita $u Department of Pathology & Molecular Medicine, Juravinski Hospital and Cancer Centre, McMaster University, Hamilton, ON, Canada. bane@hhsc.ca.
- 700 1_
- $a Terry, Mary Beth $u Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. mt146@cumc.columbia.edu.
- 700 1_
- $a John, Esther M $u Department of Epidemiology, Cancer Prevention Institute of California, Fremont, CA, USA. esther.john@cpic.org.
- 700 1_
- $a Southey, Melissa $u Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia. msouthey@unimelb.edu.au.
- 700 1_
- $a Easton, Douglas F $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. douglas@srl.cam.ac.uk.
- 700 1_
- $a Chenevix-Trench, Georgia $u Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia. georgia.trench@qimrberghofer.edu.au.
- 700 1_
- $a Antoniou, Antonis C $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. antonis@srl.cam.ac.uk.
- 700 1_
- $a Ottini, Laura $u Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy. laura.ottini@uniroma1.it.
- 773 0_
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