• Je něco špatně v tomto záznamu ?

The Anti-Inflammatory Compound Curcumin Enhances Locomotor and Sensory Recovery after Spinal Cord Injury in Rats by Immunomodulation

L. Machova Urdzikova, K. Karova, J. Ruzicka, A. Kloudova, C. Shannon, J. Dubisova, R. Murali, S. Kubinova, E. Sykova, M. Jhanwar-Uniyal, P. Jendelova,

. 2015 ; 17 (1) : . [pub] 20151231

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc17000693

Well known for its anti-oxidative and anti-inflammation properties, curcumin is a polyphenol found in the rhizome of Curcuma longa. In this study, we evaluated the effects of curcumin on behavioral recovery, glial scar formation, tissue preservation, axonal sprouting, and inflammation after spinal cord injury (SCI) in male Wistar rats. The rats were randomized into two groups following a balloon compression injury at the level of T9-T10 of the spinal cord, namely vehicle- or curcumin-treated. Curcumin was applied locally on the surface of the injured spinal cord immediately following injury and then given intraperitoneally daily; the control rats were treated with vehicle in the same manner. Curcumin treatment improved behavioral recovery within the first week following SCI as evidenced by improved Basso, Beattie, and Bresnahan (BBB) test and plantar scores, representing locomotor and sensory performance, respectively. Furthermore, curcumin treatment decreased glial scar formation by decreasing the levels of MIP1α, IL-2, and RANTES production and by decreasing NF-κB activity. These results, therefore, demonstrate that curcumin has a profound anti-inflammatory therapeutic potential in the treatment of spinal cord injury, especially when given immediately after the injury.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17000693
003      
CZ-PrNML
005      
20170118112738.0
007      
ta
008      
170103s2015 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms17010049 $2 doi
024    7_
$a 10.3390/ijms17010049 $2 doi
035    __
$a (PubMed)26729105
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Machova Urdzikova, Lucia $u Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, Prague 142 20, Czech Republic. urdzikl@gmail.com.
245    14
$a The Anti-Inflammatory Compound Curcumin Enhances Locomotor and Sensory Recovery after Spinal Cord Injury in Rats by Immunomodulation / $c L. Machova Urdzikova, K. Karova, J. Ruzicka, A. Kloudova, C. Shannon, J. Dubisova, R. Murali, S. Kubinova, E. Sykova, M. Jhanwar-Uniyal, P. Jendelova,
520    9_
$a Well known for its anti-oxidative and anti-inflammation properties, curcumin is a polyphenol found in the rhizome of Curcuma longa. In this study, we evaluated the effects of curcumin on behavioral recovery, glial scar formation, tissue preservation, axonal sprouting, and inflammation after spinal cord injury (SCI) in male Wistar rats. The rats were randomized into two groups following a balloon compression injury at the level of T9-T10 of the spinal cord, namely vehicle- or curcumin-treated. Curcumin was applied locally on the surface of the injured spinal cord immediately following injury and then given intraperitoneally daily; the control rats were treated with vehicle in the same manner. Curcumin treatment improved behavioral recovery within the first week following SCI as evidenced by improved Basso, Beattie, and Bresnahan (BBB) test and plantar scores, representing locomotor and sensory performance, respectively. Furthermore, curcumin treatment decreased glial scar formation by decreasing the levels of MIP1α, IL-2, and RANTES production and by decreasing NF-κB activity. These results, therefore, demonstrate that curcumin has a profound anti-inflammatory therapeutic potential in the treatment of spinal cord injury, especially when given immediately after the injury.
650    _2
$a zvířata $7 D000818
650    _2
$a antiflogistika $x farmakologie $7 D000893
650    _2
$a kurkumin $x farmakologie $7 D003474
650    _2
$a modely nemocí na zvířatech $7 D004195
650    12
$a imunomodulace $7 D056747
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani Wistar $7 D017208
650    12
$a obnova funkce $7 D020127
650    _2
$a mícha $x patofyziologie $7 D013116
650    _2
$a poranění míchy $x farmakoterapie $x imunologie $x patofyziologie $7 D013119
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Karova, Kristyna $u Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, Prague 142 20, Czech Republic. karova@biomed.cas.cz. Department of Neuroscience, Charles University, Second Faculty of Medicine, Prague 142 20, Czech Republic. karova@biomed.cas.cz.
700    1_
$a Ruzicka, Jiri $u Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, Prague 142 20, Czech Republic. j.ruzicka@biomed.cas.cz. Department of Neuroscience, Charles University, Second Faculty of Medicine, Prague 142 20, Czech Republic. j.ruzicka@biomed.cas.cz.
700    1_
$a Kloudova, Anna $u Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, Prague 142 20, Czech Republic. anna.kloudova@gmail.com.
700    1_
$a Shannon, Craig $u New York Medical College, New York, NY 10595, USA. cshannonmd@gmail.com.
700    1_
$a Dubisova, Jana $u Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, Prague 142 20, Czech Republic. jana.dubisova@biomed.cas.cz. Department of Neuroscience, Charles University, Second Faculty of Medicine, Prague 142 20, Czech Republic. jana.dubisova@biomed.cas.cz.
700    1_
$a Murali, Raj $u New York Medical College, New York, NY 10595, USA. Raj_Murali@NYMC.edu.
700    1_
$a Kubinova, Sarka $u Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, Prague 142 20, Czech Republic. sarka.k@biomed.cas.cz.
700    1_
$a Sykova, Eva $u Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, Prague 142 20, Czech Republic. sykova@biomed.cas.cz. Department of Neuroscience, Charles University, Second Faculty of Medicine, Prague 142 20, Czech Republic. sykova@biomed.cas.cz.
700    1_
$a Jhanwar-Uniyal, Meena $u New York Medical College, New York, NY 10595, USA. meena_jhanwar@NYMC.edu.
700    1_
$a Jendelova, Pavla $u Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, Prague 142 20, Czech Republic. jendel@biomed.cas.cz. Department of Neuroscience, Charles University, Second Faculty of Medicine, Prague 142 20, Czech Republic. jendel@biomed.cas.cz.
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 17, č. 1 (2015)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/26729105 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20170103 $b ABA008
991    __
$a 20170118112845 $b ABA008
999    __
$a ok $b bmc $g 1179833 $s 961260
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 17 $c 1 $e 20151231 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
LZP    __
$a Pubmed-20170103

Najít záznam

Citační ukazatele

Možnosti archivace