• Something wrong with this record ?

Toxicology and the biological role of methanol and ethanol: Current view

M. Pohanka

. 2016 ; 160 (1) : 54-63. [pub] 20150525

Language English Country Czech Republic

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc17006152

BACKGROUND: Alcohol variants such as ethanol and methanol are simple organic compounds widely used in foods, pharmaceuticals, chemical synthesis, etc. Both are becoming an emerging health problem; abuse of ethanol containing beverages can lead to disparate health problems and methanol is highly toxic and unfit for consumption. METHODS AND RESULTS: This review summarizes the basic knowledge about ethanol and methanol toxicity, the effect mechanism on the body, the current care of poisoned individuals and the implication of alcohols in the development of diseases. Alcohol related dementia, stroke, metabolic syndrome and hepatitis are discussed as well. Besides ethanol, methanol toxicity and its biodegradation pathways are addressed. CONCLUSIONS: The impact of ethanol and methanol on the body is shown as case reports, along with a discussion on the possible implication of alcohol in Alzheimer's disease and antidotal therapy for methanol poisoning. The role of ethanol in cancer and degenerative disorders seems to be underestimated given the current knowledge. Treatment in case of poisoning is another issue that remains unresolved even though effective protocols and drugs exist.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17006152
003      
CZ-PrNML
005      
20170308132822.0
007      
ta
008      
170210s2016 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.5507/bp.2015.023 $2 doi
035    __
$a (PubMed)26006090
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Pohanka, Miroslav $u Faculty of Military Health Sciences, University of Defense, Trebesska 1575, Hradec Kralove, Czech Republic $7 hka2010563580
245    10
$a Toxicology and the biological role of methanol and ethanol: Current view / $c M. Pohanka
520    9_
$a BACKGROUND: Alcohol variants such as ethanol and methanol are simple organic compounds widely used in foods, pharmaceuticals, chemical synthesis, etc. Both are becoming an emerging health problem; abuse of ethanol containing beverages can lead to disparate health problems and methanol is highly toxic and unfit for consumption. METHODS AND RESULTS: This review summarizes the basic knowledge about ethanol and methanol toxicity, the effect mechanism on the body, the current care of poisoned individuals and the implication of alcohols in the development of diseases. Alcohol related dementia, stroke, metabolic syndrome and hepatitis are discussed as well. Besides ethanol, methanol toxicity and its biodegradation pathways are addressed. CONCLUSIONS: The impact of ethanol and methanol on the body is shown as case reports, along with a discussion on the possible implication of alcohol in Alzheimer's disease and antidotal therapy for methanol poisoning. The role of ethanol in cancer and degenerative disorders seems to be underestimated given the current knowledge. Treatment in case of poisoning is another issue that remains unresolved even though effective protocols and drugs exist.
650    _2
$a alkoholdehydrogenasa $x účinky léků $x metabolismus $7 D000426
650    _2
$a alkoholické nápoje $x škodlivé účinky $x analýza $7 D000434
650    _2
$a alkoholismus $x etiologie $x metabolismus $7 D000437
650    _2
$a aldehyddehydrogenasa $x účinky léků $x metabolismus $7 D000444
650    _2
$a antidota $x terapeutické užití $7 D000931
650    _2
$a ethanol $x škodlivé účinky $x metabolismus $x otrava $7 D000431
650    _2
$a lidé $7 D006801
650    _2
$a methanol $x škodlivé účinky $x metabolismus $x otrava $7 D000432
650    _2
$a receptory buněčného povrchu $x účinky léků $7 D011956
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czech Republic $x 1213-8118 $g Roč. 160, č. 1 (2016), s. 54-63
910    __
$a ABA008 $b A 1502 $c 958 $y 4 $z 0
990    __
$a 20170210 $b ABA008
991    __
$a 20170308084011 $b ABA008
999    __
$a ok $b bmc $g 1192635 $s 966799
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 160 $c 1 $d 54-63 $e 20150525 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
LZP    __
$b NLK118 $a Pubmed-20170210

Find record

Citation metrics

Archiving options