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TLR4 and TLR21 expression, MIF, IFN-β, MD-2, CD14 activation, and sIgA production in chickens administered with EFAL41 strain challenged with Campylobacter jejuni
K. V, M. E, B. K, H. R, R. V, S. D, K. A, L. M, L. M, L. A, Š. Z, L. M,
Folia microbiologica.
2017 ;
62 (2) :
89-97.
[pub] 20161003
Language English Country United States
Document type Journal Article
Persistent link
https://www.medvik.cz/link/bmc17010578
- MeSH
- Campylobacter jejuni growth & development MeSH
- Cecum immunology microbiology MeSH
- Enterococcus faecium growth & development immunology MeSH
- Feces microbiology MeSH
- Immunoglobulin A, Secretory genetics MeSH
- Host-Pathogen Interactions MeSH
- Interferon-beta genetics immunology MeSH
- Campylobacter Infections diet therapy immunology microbiology veterinary MeSH
- Chickens MeSH
- Lipopolysaccharide Receptors genetics immunology MeSH
- Lymphocyte Antigen 96 genetics immunology MeSH
- Poultry Diseases diet therapy genetics immunology microbiology MeSH
- Animals, Newborn MeSH
- Probiotics pharmacology MeSH
- Protein Isoforms genetics immunology MeSH
- Receptors, Immunologic genetics immunology MeSH
- Gene Expression Regulation MeSH
- Signal Transduction MeSH
- Toll-Like Receptor 4 genetics immunology MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
The protective effect of Enterococcus faecium EFAL41 on chicken's caecum in relation to the TLR (TLR4 and TLR21) activation and production of luminal IgA challenged with Campylobacter jejuni CCM6191 was assessed. The activation of MIF, IFN-β, MD-2 and CD14 was followed-up after bacterial infection. Day-old chicks (40) were divided into four groups (n = 10): control (C), E. faecium AL41 (EFAL41), C. jejuni (CJ) and combined E. faecium AL41+C. jejuni (EFAL41+CJ). Relative mRNA expression of TLR4, TLR21 and CD14 was upregulated in the probiotic strain and infected (combined) group on day 4 and 7 post infection (p.i.). The caecal relative MD-2 mRNA expression was upregulated on day 4 p.i. in the EFAL41+CJ and CJ groups. MIF and IFN-β reached the highest levels in the combined groups on day 7 p.i. The concentration of the sIgA in intestinal flush was upregulated in EFAL41+CJ group on day 4 p.i. The results demonstrated that E. faecium EFAL41 probiotic strain can modulate the TLRs expression and modify the activation of MIF, IFN-β, MD-2 and CD14 molecules in the chickens caecum challenged with C. jejuni CCM 6191. The counts of EFAL41 were sufficient and high, similarly the counts of enterococci in both, caecum and faeces but without reduction of Campylobacter counts.
References provided by Crossref.org
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