Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Observational cohort study of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt (TIPS)

M. Routhu, V. Safka, SK. Routhu, T. Fejfar, V. Jirkovsky, A. Krajina, E. Cermakova, L. Hosak, P. Hulek,

. 2017 ; 16 (1) : 140-148.

Jazyk angličtina Země Mexiko

Typ dokumentu srovnávací studie, časopisecké články, pozorovací studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc17013318

Introduction and Aim: Hepatic encephalopathy (HE) is a common complication of transjugular intrahepatic portosystemic shunting (TIPS). It is associated with a reduced quality of life and poor prognosis. The aim of this study was to compare two groups of patients who did and did not develop overt HE after TIPS. We looked for differences between these groups before TIPS. MATERIALS AND METHODS: A study of 895 patients was conducted based on a retrospective analysis of clinical data. Data was analyzed using Fisher's exact test, Chi-square, Mann Whitney test, unpaired t-test and logistic regression. After the initial analyses, we have looked at a regression models for the factors associated with development of HE after TIPS. RESULTS: 257 (37.9%) patients developed HE after TIPS. Patients' age, pre-TIPS portal venous pressure, serum creatinine, aspartate transaminase, albumin, presence of diabetes mellitus and etiology of portal hypertension were statistically significantly associated with the occurrence of HE after TIPS (p < 0.01). However, only the age, pre-TIPS portal venous pressure, serum creatinine, presence of diabetes mellitus and etiology of portal hypertension contributed to the regression model. Patients age, serum creatinine, presence of diabetes mellitus and portal vein pressure formed the model describing development of HE after TIPS for a subgroup of patients with refractory ascites. CONCLUSION: we have identified, using a substantial sample, several factors associated with the development of HE after TIPS. This could be helpful in further research.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17013318
003      
CZ-PrNML
005      
20170425122308.0
007      
ta
008      
170413s2017 mx f 000 0|eng||
009      
AR
024    7_
$a 10.5604/16652681.1226932 $2 doi
035    __
$a (PubMed)28051803
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a mx
100    1_
$a Routhu, Michaela $u School of Psychiatry, Health Education Wessex, United Kingdom.
245    10
$a Observational cohort study of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt (TIPS) / $c M. Routhu, V. Safka, SK. Routhu, T. Fejfar, V. Jirkovsky, A. Krajina, E. Cermakova, L. Hosak, P. Hulek,
520    9_
$a Introduction and Aim: Hepatic encephalopathy (HE) is a common complication of transjugular intrahepatic portosystemic shunting (TIPS). It is associated with a reduced quality of life and poor prognosis. The aim of this study was to compare two groups of patients who did and did not develop overt HE after TIPS. We looked for differences between these groups before TIPS. MATERIALS AND METHODS: A study of 895 patients was conducted based on a retrospective analysis of clinical data. Data was analyzed using Fisher's exact test, Chi-square, Mann Whitney test, unpaired t-test and logistic regression. After the initial analyses, we have looked at a regression models for the factors associated with development of HE after TIPS. RESULTS: 257 (37.9%) patients developed HE after TIPS. Patients' age, pre-TIPS portal venous pressure, serum creatinine, aspartate transaminase, albumin, presence of diabetes mellitus and etiology of portal hypertension were statistically significantly associated with the occurrence of HE after TIPS (p < 0.01). However, only the age, pre-TIPS portal venous pressure, serum creatinine, presence of diabetes mellitus and etiology of portal hypertension contributed to the regression model. Patients age, serum creatinine, presence of diabetes mellitus and portal vein pressure formed the model describing development of HE after TIPS for a subgroup of patients with refractory ascites. CONCLUSION: we have identified, using a substantial sample, several factors associated with the development of HE after TIPS. This could be helpful in further research.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a věkové faktory $7 D000367
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a biologické markery $x krev $7 D015415
650    _2
$a rozdělení chí kvadrát $7 D016009
650    _2
$a kreatinin $x krev $7 D003404
650    _2
$a Česká republika $7 D018153
650    _2
$a komplikace diabetu $x etiologie $7 D048909
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a jaterní encefalopatie $x diagnóza $x etiologie $7 D006501
650    _2
$a lidé $7 D006801
650    _2
$a portální hypertenze $x diagnóza $x etiologie $x patofyziologie $x chirurgie $7 D006975
650    _2
$a logistické modely $7 D016015
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a transjugulární intrahepatální portosystémový zkrat $x škodlivé účinky $7 D019168
650    _2
$a retrospektivní studie $7 D012189
650    _2
$a rizikové faktory $7 D012307
650    _2
$a časové faktory $7 D013997
650    _2
$a výsledek terapie $7 D016896
650    _2
$a venózní tlak $7 D014690
650    _2
$a mladý dospělý $7 D055815
655    _2
$a srovnávací studie $7 D003160
655    _2
$a časopisecké články $7 D016428
655    _2
$a pozorovací studie $7 D064888
700    1_
$a Safka, Vaclav $u Department of Physiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Czech Republic.
700    1_
$a Routhu, Sunil Kumar $u School of Psychiatry, Health Education West Midlands, United Kingdom.
700    1_
$a Fejfar, Tomas $u Department of Internal Medicine, University Hospital in Hradec Kralove, Czech Republic.
700    1_
$a Jirkovsky, Vaclav $u Department of Internal Medicine, University Hospital in Hradec Kralove, Czech Republic.
700    1_
$a Krajina, Antonin $u Department of Radiology, University Hospital in Hradec Kralove, Czech Republic.
700    1_
$a Cermakova, Eva $u Computer Technology Center, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Czech Republic.
700    1_
$a Hosak, Ladislav $u Department of Psychiatry, University Hospital in Hradec Kralove, Czech Republic.
700    1_
$a Hulek, Petr $u Department of Psychiatry, University Hospital in Hradec Kralove, Czech Republic. Department of Psychiatry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Czech Republic
773    0_
$w MED00172549 $t Annals of hepatology $x 1665-2681 $g Roč. 16, č. 1 (2017), s. 140-148
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28051803 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20170413 $b ABA008
991    __
$a 20170425122625 $b ABA008
999    __
$a ok $b bmc $g 1199783 $s 974096
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 16 $c 1 $d 140-148 $i 1665-2681 $m Annals of hepatology $n Ann Hepatol $x MED00172549
LZP    __
$a Pubmed-20170413

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace