Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Utilizing Autologous Multipotent Mesenchymal Stromal Cells and β-Tricalcium Phosphate Scaffold in Human Bone Defects: A Prospective, Controlled Feasibility Trial

P. Šponer, S. Filip, T. Kučera, J. Brtková, K. Urban, V. Palička, Z. Kočí, M. Syka, A. Bezrouk, E. Syková,

. 2016 ; 2016 (-) : 2076061. [pub] 20160407

Jazyk angličtina Země Spojené státy americké

Typ dokumentu klinické zkoušky, fáze II, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17013884

Grantová podpora
NT13477 MZ0 CEP - Centrální evidence projektů

The purpose of this prospective controlled study was to compare healing quality following the implantation of ultraporous β-tricalcium phosphate, containing either expanded autologous mesenchymal stromal cells (trial group, 9 patients) or β-tricalcium phosphate alone (control group, 9 patients), into femoral defects during revision total hip arthroplasty. Both groups were assessed using the Harris Hip Score, radiography, and DEXA scanning at 6 weeks and 3, 6, and 12 months postoperatively. A significant difference in the bone defect healing was observed between both groups of patients (P < 0.05). In the trial group, trabecular remodeling was found in all nine patients and in the control group, in 1 patient only. Whereas, over the 12-month follow-up period, no significant difference was observed between both groups of patients in terms of the resorption of β-tricalcium phosphate, the significant differences were documented in the presence of radiolucency and bone trabeculation through the defect (P < 0.05). Using autologous mesenchymal stromal cells combined with a β-tricalcium phosphate scaffold is a feasible, safe, and effective approach for management of bone defects with compromised microenvironment. The clinical trial was registered at the EU Clinical Trials Register before patient recruitment has begun (EudraCT number 2012-005599-33).

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17013884
003      
CZ-PrNML
005      
20181115091614.0
007      
ta
008      
170413s2016 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1155/2016/2076061 $2 doi
035    __
$a (PubMed)27144159
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Šponer, Pavel, $u Department of Orthopaedic Surgery, Charles University in Prague, Faculty of Medicine in Hradec Králové, Šimkova 870, 500 38 Hradec Králové, Czech Republic. $d 1969- $7 xx0035643
245    10
$a Utilizing Autologous Multipotent Mesenchymal Stromal Cells and β-Tricalcium Phosphate Scaffold in Human Bone Defects: A Prospective, Controlled Feasibility Trial / $c P. Šponer, S. Filip, T. Kučera, J. Brtková, K. Urban, V. Palička, Z. Kočí, M. Syka, A. Bezrouk, E. Syková,
520    9_
$a The purpose of this prospective controlled study was to compare healing quality following the implantation of ultraporous β-tricalcium phosphate, containing either expanded autologous mesenchymal stromal cells (trial group, 9 patients) or β-tricalcium phosphate alone (control group, 9 patients), into femoral defects during revision total hip arthroplasty. Both groups were assessed using the Harris Hip Score, radiography, and DEXA scanning at 6 weeks and 3, 6, and 12 months postoperatively. A significant difference in the bone defect healing was observed between both groups of patients (P < 0.05). In the trial group, trabecular remodeling was found in all nine patients and in the control group, in 1 patient only. Whereas, over the 12-month follow-up period, no significant difference was observed between both groups of patients in terms of the resorption of β-tricalcium phosphate, the significant differences were documented in the presence of radiolucency and bone trabeculation through the defect (P < 0.05). Using autologous mesenchymal stromal cells combined with a β-tricalcium phosphate scaffold is a feasible, safe, and effective approach for management of bone defects with compromised microenvironment. The clinical trial was registered at the EU Clinical Trials Register before patient recruitment has begun (EudraCT number 2012-005599-33).
650    _2
$a senioři $7 D000368
650    12
$a náhrada kyčelního kloubu $7 D019644
650    _2
$a regenerace kostí $x fyziologie $7 D001861
650    _2
$a remodelace kosti $x účinky léků $x fyziologie $7 D016723
650    _2
$a fosforečnany vápenaté $x terapeutické užití $7 D002130
650    _2
$a trabekulární kostní tkáň $x účinky léků $x patofyziologie $x chirurgie $7 D000071556
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a femur $x patofyziologie $x chirurgie $7 D005269
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a transplantace mezenchymálních kmenových buněk $x metody $7 D045164
650    _2
$a mezenchymální kmenové buňky $7 D059630
650    _2
$a lidé středního věku $7 D008875
650    _2
$a tkáňové podpůrné struktury $x chemie $7 D054457
650    12
$a autologní transplantace $7 D014182
650    _2
$a výsledek terapie $7 D016896
655    _2
$a klinické zkoušky, fáze II $7 D017427
655    _2
$a časopisecké články $7 D016428
700    1_
$a Filip, Stanislav, $u Department of Oncology and Radiotherapy, Charles University in Prague, Faculty of Medicine in Hradec Králové, Šimkova 870, 500 38 Hradec Králové, Czech Republic. $d 1961- $7 jn20010309153
700    1_
$a Kučera, Tomáš $u Department of Orthopaedic Surgery, University Hospital in Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic. $7 xx0208976
700    1_
$a Brtková, Jindra $u Department of Radiology, University Hospital in Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic. $7 xx0106394
700    1_
$a Urban, Karel, $u Department of Orthopaedic Surgery, University Hospital in Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic. $d 1943- $7 skuk0005685
700    1_
$a Palička, Vladimír, $u Institute for Clinical Biochemistry and Diagnostics, Charles University in Prague, Faculty of Medicine in Hradec Králové, Šimkova 870, 500 38 Hradec Králové, Czech Republic. $d 1946- $7 jn99240000830
700    1_
$a Kočí, Zuzana $u Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20 Prague, Czech Republic; Department of Neuroscience, 2nd Faculty of Medicine, Charles University in Prague, V Úvalu 84, 150 06 Prague, Czech Republic.
700    1_
$a Syka, Michael $u Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20 Prague, Czech Republic.
700    1_
$a Bezrouk, Aleš $u Department of Medical Biophysics, Charles University in Prague, Faculty of Medicine in Hradec Králové, Šimkova 870, 500 38 Hradec Králové, Czech Republic. $7 xx0193795
700    1_
$a Syková, Eva, $u Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20 Prague, Czech Republic; Department of Neuroscience, 2nd Faculty of Medicine, Charles University in Prague, V Úvalu 84, 150 06 Prague, Czech Republic. $d 1944- $7 jn20000710633
773    0_
$w MED00182164 $t BioMed research international $x 2314-6141 $g Roč. 2016, č. - (2016), s. 2076061
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27144159 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20170413 $b ABA008
991    __
$a 20181115091702 $b ABA008
999    __
$a ok $b bmc $g 1200349 $s 974662
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 2016 $c - $d 2076061 $e 20160407 $i 2314-6141 $m BioMed research international $n Biomed Res Int $x MED00182164
GRA    __
$a NT13477 $p MZ0
LZP    __
$a Pubmed-20170413

Najít záznam

Citační ukazatele

Možnosti archivace