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Febrile urinary tract infection after pediatric kidney transplantation: a multicenter, prospective observational study

F. Weigel, A. Lemke, B. Tönshoff, L. Pape, H. Fehrenbach, M. Henn, B. Hoppe, T. Jungraithmayr, M. Konrad, G. Laube, M. Pohl, T. Seeman, H. Staude, MJ. Kemper, U. John,

. 2016 ; 31 (6) : 1021-8. [pub] 20160111

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články, multicentrická studie, pozorovací studie, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc17014167
E-zdroje Online Plný text

NLK ProQuest Central od 1996-08-01 do Před 1 rokem
Medline Complete (EBSCOhost) od 1996-08-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest) od 1996-08-01 do Před 1 rokem
Health & Medicine (ProQuest) od 1996-08-01 do Před 1 rokem
Family Health Database (ProQuest) od 1996-08-01 do Před 1 rokem

Odkazy

PubMed 26754038
DOI 10.1007/s00467-015-3292-2
Knihovny.cz E-zdroje

BACKGROUND: Febrile urinary tract infections (fUTIs) are common after kidney transplantation (KTx); however, prospective data in a multicenter pediatric cohort are lacking. We designed a prospective registry to record data on fUTI before and after pediatric KTx. METHODS: Ninety-eight children (58 boys and 40 girls) ≤ 18 years from 14 mid-European centers received a kidney transplant and completed a 2-year follow-up. RESULTS: Posttransplant, 38.7% of patients had at least one fUTI compared with 21.4% before KTx (p = 0.002). Before KTx, fUTI was more frequent in patients with congenital anomalies of kidneys and urinary tract (CAKUT) vs. patients without (38% vs. 12%; p = 0.005). After KTx, fUTI were equally frequent in both groups (48.7% vs. 32.2%; p = 0.14). First fUTI posttransplant occurred earlier in boys compared with girls: median range 4 vs. 13.5 years (p = 0.002). Graft function worsened (p < 0.001) during fUTI, but no difference was recorded after 2 years. At least one recurrence of fUTI was encountered in 58%. CONCLUSION: This prospective study confirms a high incidence of fUTI after pediatric KTx, which is not restricted to patients with CAKUT; fUTIs have a negative impact on graft function during the infectious episode but not on 2-year graft outcome.

Citace poskytuje Crossref.org

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