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The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance
M. Broz, P. Steiner, R. Salzman, L. Hauer, I. Starek
Language English Country Czech Republic
Document type Journal Article
NLK
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from 2001
Free Medical Journals
from 1998
Medline Complete (EBSCOhost)
from 2007-06-01
ROAD: Directory of Open Access Scholarly Resources
from 2001
PubMed
27174194
DOI
10.5507/bp.2016.027
Knihovny.cz E-resources
- MeSH
- Carcinoma, Adenoid Cystic genetics mortality MeSH
- Adult MeSH
- Genetic Predisposition to Disease genetics MeSH
- Genes, myb genetics MeSH
- In Situ Hybridization, Fluorescence MeSH
- Middle Aged MeSH
- Humans MeSH
- Salivary Gland Neoplasms genetics mortality MeSH
- Prognosis MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
AIMS: To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parameters METHODS: MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffin-embedded blocks. The Kaplan-Meier survival analysis was used to estimate prognosis. RESULTS: Fifteen of 23 evaluated tumours were MYB positive and 8 MYB negative. The 10-year cumulative survival, respectively disease free interval, was 60.0%, respectively 59.3%, in MYB positive patients and 88.5%, respectively 80.0%, in MYB negative patients (long rank test, P=0.23). There were no significant differences in age, gender, perineural invasion, the presence of hematogenic or nodal metastases or degree of histopathological grading between MYB positive and MYB negative patients. CONCLUSION: A tendency to differences in the survival of patients with ACC, depending on their MYB status. MYB negative patients were predisposed to better prognosis.
References provided by Crossref.org
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