In this work, design and synthesis of high-molecular-weight N-(2-hydroxypropyl)methacrylamide-based polymer drug delivery systems tailored for cancer therapy is summarized. Moreover, the influence of their architecture on tumor accumulation and in vivo anti-cancer efficacy is discussed. Mainly, the high-molecular-weight delivery systems, such as branched, grafted, multi-block, star-like or micellar systems, with molecular weights greater than the renal threshold are discussed and reviewed in detail.

Department of Biomedicinal Polymers Institute of Macromolecular Chemistry of the Czech Academy of Sciences Prague Czech Republic

000      

00000naa a2200000 a 4500

001      

bmc17021002

003      

CZ-PrNML

005      

20190814101004.0

007      

ta

008      

170623s2016 xr d f 000 0|eng||

009      

AR

024    7_

$a 10.33549/physiolres.933420 $2 doi

035    __

$a (PubMed)27762584

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a xr

100    1_

$a Kostka, Libor $u Department of Biomedicinal Polymers, Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Prague, Czech Republic $7 xx0232772

245    10

$a High-molecular-weight HPMA-based polymer drug carriers for delivery to tumor / $c L. Kostka, T. Etrych

520    9_

$a In this work, design and synthesis of high-molecular-weight N-(2-hydroxypropyl)methacrylamide-based polymer drug delivery systems tailored for cancer therapy is summarized. Moreover, the influence of their architecture on tumor accumulation and in vivo anti-cancer efficacy is discussed. Mainly, the high-molecular-weight delivery systems, such as branched, grafted, multi-block, star-like or micellar systems, with molecular weights greater than the renal threshold are discussed and reviewed in detail.

650    12

$a antitumorózní látky $7 D000970

650    12

$a nosiče léků $7 D004337

650    12

$a methakryláty $7 D008689

650    _2

$a micely $7 D008823

650    _2

$a nanočástice $7 D053758

650    12

$a polymery $7 D011108

650    _2

$a prekurzory léčiv $7 D011355

655    _2

$a časopisecké články $7 D016428

655    _2

$a přehledy $7 D016454

700    1_

$a Etrych, Tomáš $7 xx0068504 $u Department of Biomedicinal Polymers, Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Prague, Czech Republic

773    0_

$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 65, Suppl. 2 (2016), s. S179-S190

773    0_

$t Recent achievements from Otto Wichterle Innovation Centre of Polymeric Materials and Biocev Research Projects $x 1802-9973 $g Roč. 65, Suppl. 2 (2016), s. S179-S190 $w MED00196542

856    41

$u http://www.biomed.cas.cz/physiolres/ $y domovská stránka časopisu

910    __

$a ABA008 $b A 4120 $c 266 $y 4 $z 0

990    __

$a 20170623 $b ABA008

991    __

$a 20190814101230 $b ABA008

999    __

$a ok $b bmc $g 1236298 $s 981875

BAS    __

$a 3

BAS    __

$a PreBMC

BMC    __

$a 2016 $b 65 $c Suppl. 2 $d S179-S190 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824

BMC    __

$a 2016 $b 65 $c Suppl. 2 $d S179-S190 $i 1802-9973 $m Recent achievements from Otto Wichterle Innovation Centre of Polymeric Materials and Biocev Research Projects $x MED00196542

LZP    __

$b NLK118 $a Pubmed-20170623