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Parvovirus B19 induced lupus-like syndrome with nephritis
E. Georges, Z. Rihova, R. Cmejla, PY. Decleire, C. Langen,
Language English Country England, Great Britain
Document type Case Reports, Journal Article
NLK
ProQuest Central
from 2011-01-01 to 2016-11-30
Health & Medicine (ProQuest)
from 2011-01-01 to 2016-11-30
- MeSH
- Acute Disease MeSH
- Autoimmune Diseases * MeSH
- Biopsy MeSH
- DNA, Viral analysis MeSH
- Glomerulonephritis drug therapy immunology virology MeSH
- Kidney Glomerulus diagnostic imaging MeSH
- Immunosuppressive Agents therapeutic use MeSH
- Parvoviridae Infections MeSH
- Humans MeSH
- Parvovirus B19, Human isolation & purification MeSH
- Aged MeSH
- Syndrome MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
We report a case of a 65-year-old man who developed an acute illness with fever, arthralgia and nephritic syndrome. Antinuclear antibodies were slightly positive and complement levels were low. Renal biopsy showed exudative diffuse proliferative endocapillary glomerulonephritis with diffuse immunoglobulin (IgG, IgA, IgM) and complement deposition (C3d, C4d, C1q) on immunofluorescence. The patient was first treated with corticosteroids and mycophenolate mofetil for suspected lupus with WHO class IV glomerulonephritis. The diagnosis was questioned and a diagnosis of parvovirus B19-associated nephritis was made based on elevation of serum IgM antibodies for parvovirus B19 and detection of parvovirus B19 DNA on renal biopsy. The immunosuppressive treatment was stopped and progressive spontaneous regression of clinical and laboratory abnormalities was observed. We conclude that human parvovirus B19 infection should be considered as a cause of lupus-like symptomatology and acute glomerulonephritis.
b Nephrology Department CSL Vivalia Arlon Belgium
References provided by Crossref.org
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