• Something wrong with this record ?

Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls

J. Trnovská, J. Šilhavý, O. Kuda, V. Landa, V. Zídek, P. Mlejnek, M. Šimáková, H. Strnad, V. Škop, O. Oliyarnyk, L. Kazdová, M. Haluzík, M. Pravenec,

. 2017 ; 12 (6) : e0179063. [pub] 20170606

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc17030769

Chronic low-grade inflammation plays an important role in the pathogenesis of insulin resistance. In the current study, we tested the effects of salsalate, a non-steroidal anti-inflammatory drug, in an animal model of inflammation and metabolic syndrome using spontaneously hypertensive rats (SHR) that transgenically express human C-reactive protein (SHR-CRP rats). We treated 15-month-old male transgenic SHR-CRP rats and nontransgenic SHR with salsalate (200 mg/kg/day) mixed as part of a standard diet for 4 weeks. A corresponding untreated control group of male transgenic SHR-CRP and SHR rats were fed a standard diet without salsalate. In the SHR-CRP transgenic strain, salsalate treatment decreased circulating concentrations of the inflammatory markers TNF-α and MCP-1, reduced oxidative stress in the liver and kidney, increased sensitivity of skeletal muscles to insulin action and improved tolerance to glucose. In SHR controls with no CRP-induced inflammation, salsalate treatment reduced body weight, decreased concentrations of serum free fatty acids and total and HDL cholesterol and increased palmitate oxidation and incorporation in brown adipose tissue. Salsalate regulated inflammation by affecting the expression of genes from MAPK signalling and NOD-like receptor signalling pathways and lipid metabolism by affecting hepatic expression of genes that favour lipid oxidation from PPAR-α signalling pathways. These findings suggest that salsalate has metabolic effects beyond suppressing inflammation.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17030769
003      
CZ-PrNML
005      
20171025122738.0
007      
ta
008      
171025s2017 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1371/journal.pone.0179063 $2 doi
035    __
$a (PubMed)28586387
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Trnovská, Jaroslava $u Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
245    10
$a Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls / $c J. Trnovská, J. Šilhavý, O. Kuda, V. Landa, V. Zídek, P. Mlejnek, M. Šimáková, H. Strnad, V. Škop, O. Oliyarnyk, L. Kazdová, M. Haluzík, M. Pravenec,
520    9_
$a Chronic low-grade inflammation plays an important role in the pathogenesis of insulin resistance. In the current study, we tested the effects of salsalate, a non-steroidal anti-inflammatory drug, in an animal model of inflammation and metabolic syndrome using spontaneously hypertensive rats (SHR) that transgenically express human C-reactive protein (SHR-CRP rats). We treated 15-month-old male transgenic SHR-CRP rats and nontransgenic SHR with salsalate (200 mg/kg/day) mixed as part of a standard diet for 4 weeks. A corresponding untreated control group of male transgenic SHR-CRP and SHR rats were fed a standard diet without salsalate. In the SHR-CRP transgenic strain, salsalate treatment decreased circulating concentrations of the inflammatory markers TNF-α and MCP-1, reduced oxidative stress in the liver and kidney, increased sensitivity of skeletal muscles to insulin action and improved tolerance to glucose. In SHR controls with no CRP-induced inflammation, salsalate treatment reduced body weight, decreased concentrations of serum free fatty acids and total and HDL cholesterol and increased palmitate oxidation and incorporation in brown adipose tissue. Salsalate regulated inflammation by affecting the expression of genes from MAPK signalling and NOD-like receptor signalling pathways and lipid metabolism by affecting hepatic expression of genes that favour lipid oxidation from PPAR-α signalling pathways. These findings suggest that salsalate has metabolic effects beyond suppressing inflammation.
650    _2
$a hnědá tuková tkáň $x metabolismus $7 D002001
650    _2
$a zvířata $7 D000818
650    _2
$a geneticky modifikovaná zvířata $x genetika $7 D030801
650    _2
$a C-reaktivní protein $x biosyntéza $x genetika $7 D002097
650    _2
$a kyseliny mastné neesterifikované $x metabolismus $7 D005230
650    _2
$a lidé $7 D006801
650    _2
$a hypertenze $x farmakoterapie $x genetika $x patologie $7 D006973
650    _2
$a zánět $x farmakoterapie $x genetika $x patologie $7 D007249
650    _2
$a inzulinová rezistence $x genetika $7 D007333
650    _2
$a metabolismus lipidů $x účinky léků $7 D050356
650    _2
$a játra $x metabolismus $7 D008099
650    _2
$a metabolický syndrom $x farmakoterapie $x genetika $x patologie $7 D024821
650    _2
$a NLR proteiny $x biosyntéza $7 D000070576
650    _2
$a oxidační stres $x účinky léků $7 D018384
650    _2
$a PPAR alfa $x biosyntéza $7 D047493
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a salicylany $x aplikace a dávkování $7 D012459
650    _2
$a TNF-alfa $x biosyntéza $7 D014409
655    _2
$a časopisecké články $7 D016428
700    1_
$a Šilhavý, Jan $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
700    1_
$a Kuda, Ondřej $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
700    1_
$a Landa, Vladimír $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
700    1_
$a Zídek, Václav $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
700    1_
$a Mlejnek, Petr $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
700    1_
$a Šimáková, Miroslava $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
700    1_
$a Strnad, Hynek $u Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic.
700    1_
$a Škop, Vojtěch $u Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
700    1_
$a Oliyarnyk, Olena $u Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
700    1_
$a Kazdová, Ludmila $u Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
700    1_
$a Haluzík, Martin $u Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic.
700    1_
$a Pravenec, Michal $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
773    0_
$w MED00180950 $t PloS one $x 1932-6203 $g Roč. 12, č. 6 (2017), s. e0179063
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28586387 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20171025 $b ABA008
991    __
$a 20171025122820 $b ABA008
999    __
$a ok $b bmc $g 1254362 $s 991796
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 12 $c 6 $d e0179063 $e 20170606 $i 1932-6203 $m PLoS One $n PLoS One $x MED00180950
LZP    __
$a Pubmed-20171025

Find record

Citation metrics

Archiving options