-
Something wrong with this record ?
Multivacuolated mucin-filled cells: a unique cell characteristic of plexiform neurofibroma. A report of 11 cases
M. Michal, DV. Kazakov, L. Hadravský, K. Michalová, B. Rychlý, M. Michal,
Language English Country United States
Document type Journal Article
- MeSH
- Antigens, CD34 analysis MeSH
- Biopsy MeSH
- Claudin-1 analysis MeSH
- Child MeSH
- Adult MeSH
- Immunohistochemistry MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Mucins analysis MeSH
- Biomarkers, Tumor analysis MeSH
- Neurofibromatosis 1 metabolism pathology MeSH
- Neurofibroma, Plexiform chemistry pathology MeSH
- Predictive Value of Tests MeSH
- Glucose Transporter Type 1 analysis MeSH
- Prognosis MeSH
- Aged MeSH
- Vacuoles chemistry pathology MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
The authors present 11 cases of plexiform neurofibroma (PN) that featured a very characteristic type of cell appearing as multivacuolated mucin-filled cells (MMFC). The 11 cases were obtained after reviewing 109 cases of PN. Six out of 10 patients showed clinical features of neurofibromatosis type 1. The size of PN ranged from 0.8 cm to 11.5 cm in the largest dimension. The lesions represented classical PN in all cases with myxoid, hypocellular stroma. The MMFC were found within the most myxoid tumorous nodules and were haphazardly located, typically featuring a variably sized, multivacuolated cytoplasm divided by fine septa with a small polygonal nucleus on one side, which was often compressed or slightly indented by the cytoplasmic mucous substances. In many cases, the cells resembled a soccer ball or a jellyfish. In all tested cases (n = 9), the MMFC stained for CD34; six cases were also positive with GLUT-1 antibody, and two cases expressed Claudin-1, whereas S-100 protein was negative. For comparison, we have reviewed a series of randomly selected non-PN, malignant peripheral nerve sheath tumors (MPNST) and of cases featuring non-neoplastic nerve trunks in our files, in which no MMFC were encountered. MMFC seem to be unique to myxoid areas of PN, where they occur in about 10% of cases. Their exact histogenesis is unclear but they might represent an intermediate type of cell between perineurial cells and fibroblasts. The awareness of this cell type in PN is especially important in limited (small) biopsy specimens where their recognition may provide a clue for the correct diagnosis.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc17031306
- 003
- CZ-PrNML
- 005
- 20171025122941.0
- 007
- ta
- 008
- 171025s2017 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.humpath.2016.10.010 $2 doi
- 035 __
- $a (PubMed)27816720
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Michal, Michael $u Department of Pathology, Charles University, Biomedical Center, Faculty of Medicine in Plzen and Charles University Hospital Plzen, Alej Svobody 80, 304 60 Pilsen, Czech Republic. Electronic address: michael.michal@medima.cz.
- 245 10
- $a Multivacuolated mucin-filled cells: a unique cell characteristic of plexiform neurofibroma. A report of 11 cases / $c M. Michal, DV. Kazakov, L. Hadravský, K. Michalová, B. Rychlý, M. Michal,
- 520 9_
- $a The authors present 11 cases of plexiform neurofibroma (PN) that featured a very characteristic type of cell appearing as multivacuolated mucin-filled cells (MMFC). The 11 cases were obtained after reviewing 109 cases of PN. Six out of 10 patients showed clinical features of neurofibromatosis type 1. The size of PN ranged from 0.8 cm to 11.5 cm in the largest dimension. The lesions represented classical PN in all cases with myxoid, hypocellular stroma. The MMFC were found within the most myxoid tumorous nodules and were haphazardly located, typically featuring a variably sized, multivacuolated cytoplasm divided by fine septa with a small polygonal nucleus on one side, which was often compressed or slightly indented by the cytoplasmic mucous substances. In many cases, the cells resembled a soccer ball or a jellyfish. In all tested cases (n = 9), the MMFC stained for CD34; six cases were also positive with GLUT-1 antibody, and two cases expressed Claudin-1, whereas S-100 protein was negative. For comparison, we have reviewed a series of randomly selected non-PN, malignant peripheral nerve sheath tumors (MPNST) and of cases featuring non-neoplastic nerve trunks in our files, in which no MMFC were encountered. MMFC seem to be unique to myxoid areas of PN, where they occur in about 10% of cases. Their exact histogenesis is unclear but they might represent an intermediate type of cell between perineurial cells and fibroblasts. The awareness of this cell type in PN is especially important in limited (small) biopsy specimens where their recognition may provide a clue for the correct diagnosis.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a antigeny CD34 $x analýza $7 D018952
- 650 _2
- $a nádorové biomarkery $x analýza $7 D014408
- 650 _2
- $a biopsie $7 D001706
- 650 _2
- $a dítě $7 D002648
- 650 _2
- $a claudin-1 $x analýza $7 D062445
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a přenašeč glukosy typ 1 $x analýza $7 D051272
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a imunohistochemie $7 D007150
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a muciny $x analýza $7 D009077
- 650 _2
- $a plexiformní neurofibrom $x chemie $x patologie $7 D018318
- 650 _2
- $a neurofibromatóza 1 $x metabolismus $x patologie $7 D009456
- 650 _2
- $a prediktivní hodnota testů $7 D011237
- 650 _2
- $a prognóza $7 D011379
- 650 _2
- $a vakuoly $x chemie $x patologie $7 D014617
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Kazakov, Dmitry V $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
- 700 1_
- $a Hadravský, Ladislav $u Department of Pathology, Charles University, Third Medical Faculty and Charles University Hospital Kralovske Vinohrady, Šrobárova 50, 100 34 Prague, Czech Republic.
- 700 1_
- $a Michalová, Květoslava $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
- 700 1_
- $a Rychlý, Boris $u Cytopathos, Limbová 5, 833 07, Bratislava 37, Slovakia.
- 700 1_
- $a Michal, Michal $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
- 773 0_
- $w MED00002080 $t Human pathology $x 1532-8392 $g Roč. 60, č. - (2017), s. 167-173
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/27816720 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20171025 $b ABA008
- 991 __
- $a 20171025123023 $b ABA008
- 999 __
- $a ok $b bmc $g 1254899 $s 992333
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2017 $b 60 $c - $d 167-173 $e 20161102 $i 1532-8392 $m Human pathology $n Hum Pathol $x MED00002080
- LZP __
- $a Pubmed-20171025
