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Consensus paper of the WFSBP Task Force on Genetics: Genetics, epigenetics and gene expression markers of major depressive disorder and antidepressant response
C. Fabbri, L. Hosak, R. Mössner, I. Giegling, L. Mandelli, F. Bellivier, S. Claes, DA. Collier, A. Corrales, LE. Delisi, C. Gallo, M. Gill, JL. Kennedy, M. Leboyer, A. Lisoway, W. Maier, M. Marquez, I. Massat, O. Mors, P. Muglia, MM. Nöthen, MC....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, přehledy
- MeSH
- antidepresiva terapeutické užití MeSH
- depresivní porucha unipolární farmakoterapie genetika MeSH
- epigeneze genetická * MeSH
- genetické markery * MeSH
- konsensus MeSH
- lidé MeSH
- neuroplasticita MeSH
- randomizované kontrolované studie jako téma MeSH
- transkriptom MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Major depressive disorder (MDD) is a heritable disease with a heavy personal and socio-economic burden. Antidepressants of different classes are prescribed to treat MDD, but reliable and reproducible markers of efficacy are not available for clinical use. Further complicating treatment, the diagnosis of MDD is not guided by objective criteria, resulting in the risk of under- or overtreatment. A number of markers of MDD and antidepressant response have been investigated at the genetic, epigenetic, gene expression and protein levels. Polymorphisms in genes involved in antidepressant metabolism (cytochrome P450 isoenzymes), antidepressant transport (ABCB1), glucocorticoid signalling (FKBP5) and serotonin neurotransmission (SLC6A4 and HTR2A) were among those included in the first pharmacogenetic assays that have been tested for clinical applicability. The results of these investigations were encouraging when examining patient-outcome improvement. Furthermore, a nine-serum biomarker panel (including BDNF, cortisol and soluble TNF-α receptor type II) showed good sensitivity and specificity in differentiating between MDD and healthy controls. These first diagnostic and response-predictive tests for MDD provided a source of optimism for future clinical applications. However, such findings should be considered very carefully because their benefit/cost ratio and clinical indications were not clearly demonstrated. Future tests may include combinations of different types of biomarkers and be specific for MDD subtypes or pathological dimensions.
c Department of Psychiatry and Psychotherapy University of Tübingen Tübingen Germany
Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy
Department of Psychiatry University of Bonn Bonn Germany
f GRASP Research Group Department of Neuroscience University of Leuven Leuven Belgium
i VA Boston Health Care System Brockton MA USA
l Neurogenetics Section Centre for Addiction and Mental Health Toronto Ontario Canada
o Director of ADINEU Buenos Aires Argentina
p UNI ULB Neurosciences Institute ULB Bruxelles Belgium
q Department P Aarhus University Hospital Risskov Denmark
s Institute of Human Genetics University of Bonn Bonn Germany
x University of Aberdeen Institute of Medical Sciences Aberdeen UK
y University Hospital Cochin INSERM U 894 Centre Psychiatry and Neurosciences Paris France
z Division of Medical Genetics Department of Biomedicine University of Basel Basel Switzerland
Citace poskytuje Crossref.org
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- $a Major depressive disorder (MDD) is a heritable disease with a heavy personal and socio-economic burden. Antidepressants of different classes are prescribed to treat MDD, but reliable and reproducible markers of efficacy are not available for clinical use. Further complicating treatment, the diagnosis of MDD is not guided by objective criteria, resulting in the risk of under- or overtreatment. A number of markers of MDD and antidepressant response have been investigated at the genetic, epigenetic, gene expression and protein levels. Polymorphisms in genes involved in antidepressant metabolism (cytochrome P450 isoenzymes), antidepressant transport (ABCB1), glucocorticoid signalling (FKBP5) and serotonin neurotransmission (SLC6A4 and HTR2A) were among those included in the first pharmacogenetic assays that have been tested for clinical applicability. The results of these investigations were encouraging when examining patient-outcome improvement. Furthermore, a nine-serum biomarker panel (including BDNF, cortisol and soluble TNF-α receptor type II) showed good sensitivity and specificity in differentiating between MDD and healthy controls. These first diagnostic and response-predictive tests for MDD provided a source of optimism for future clinical applications. However, such findings should be considered very carefully because their benefit/cost ratio and clinical indications were not clearly demonstrated. Future tests may include combinations of different types of biomarkers and be specific for MDD subtypes or pathological dimensions.
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