• Something wrong with this record ?

Effect of Lactobacillus casei on the Pharmacokinetics of Amiodarone in Male Wistar Rats

Z. Matuskova, P. Anzenbacher, R. Vecera, M. Siller, H. Tlaskalova-Hogenova, J. Strojil, E. Anzenbacherova,

. 2017 ; 42 (1) : 29-36.

Language English Country France

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc17031866

BACKGROUND AND OBJECTIVES: The probiotic bacterium Escherichia coli strain Nissle 1917 has previously been shown to alter the pharmacokinetics of amiodarone. The aim of this study was to determine whether the probiotic bacterium Lactobacillus casei produces similar alterations in amiodarone disposition. METHODS: A suspension of live probiotic bacteria L. casei strain DN-114 001 (1.5 × 10(9) CFU/dose; probiotic pre-treated group) or a saline solution (control group) was administered directly into the stomach of male Wistar rats (N = 30 in each group) by oral gavage daily for 7 consecutive days. On the eighth day, all rats (N = 60) were given a single oral dose of an amiodarone hydrochloride suspension (model drug; 50 mg/kg). The concentrations of amiodarone and of its main metabolite N-desethylamiodarone were determined in rat plasma by high-performance liquid chromatography. RESULTS: Comparison of the pharmacokinetics of amiodarone in the control group and probiotic pre-treated group revealed that the peak plasma concentration of amiodarone was delayed by >2 h in the probiotic pre-treated group. The plasma level of N-desethylamiodarone was unchanged in the probiotic pre-medicated group and its pharmacokinetic parameters were not altered. CONCLUSIONS: The slower absorption of amiodarone in the probiotic pre-treated rats compared to the control ones and the unchanged pharmacokinetics of its main metabolite suggest that the probiotic strain of L. casei DN-114 001 has probably no clinical consequences as the difference was not statistically significant.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17031866
003      
CZ-PrNML
005      
20180214202132.0
007      
ta
008      
171025s2017 fr f 000 0|eng||
009      
AR
024    7_
$a 10.1007/s13318-015-0315-0 $2 doi
035    __
$a (PubMed)26797809
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a fr
100    1_
$a Matuskova, Zuzana $u Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic. Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 5, 779 00, Olomouc, Czech Republic.
245    10
$a Effect of Lactobacillus casei on the Pharmacokinetics of Amiodarone in Male Wistar Rats / $c Z. Matuskova, P. Anzenbacher, R. Vecera, M. Siller, H. Tlaskalova-Hogenova, J. Strojil, E. Anzenbacherova,
520    9_
$a BACKGROUND AND OBJECTIVES: The probiotic bacterium Escherichia coli strain Nissle 1917 has previously been shown to alter the pharmacokinetics of amiodarone. The aim of this study was to determine whether the probiotic bacterium Lactobacillus casei produces similar alterations in amiodarone disposition. METHODS: A suspension of live probiotic bacteria L. casei strain DN-114 001 (1.5 × 10(9) CFU/dose; probiotic pre-treated group) or a saline solution (control group) was administered directly into the stomach of male Wistar rats (N = 30 in each group) by oral gavage daily for 7 consecutive days. On the eighth day, all rats (N = 60) were given a single oral dose of an amiodarone hydrochloride suspension (model drug; 50 mg/kg). The concentrations of amiodarone and of its main metabolite N-desethylamiodarone were determined in rat plasma by high-performance liquid chromatography. RESULTS: Comparison of the pharmacokinetics of amiodarone in the control group and probiotic pre-treated group revealed that the peak plasma concentration of amiodarone was delayed by >2 h in the probiotic pre-treated group. The plasma level of N-desethylamiodarone was unchanged in the probiotic pre-medicated group and its pharmacokinetic parameters were not altered. CONCLUSIONS: The slower absorption of amiodarone in the probiotic pre-treated rats compared to the control ones and the unchanged pharmacokinetics of its main metabolite suggest that the probiotic strain of L. casei DN-114 001 has probably no clinical consequences as the difference was not statistically significant.
650    _2
$a aplikace orální $7 D000284
650    _2
$a amiodaron $x aplikace a dávkování $x krev $x farmakokinetika $7 D000638
650    _2
$a zvířata $7 D000818
650    12
$a Lactobacillus casei $7 D007780
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a probiotika $x aplikace a dávkování $x farmakologie $7 D019936
650    _2
$a krysa rodu Rattus $7 D051381
655    _2
$a časopisecké články $7 D016428
700    1_
$a Anzenbacher, Pavel $u Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic. Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 5, 779 00, Olomouc, Czech Republic. $7 xx0034447 $4
700    1_
$a Vecera, Rostislav $u Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic.
700    1_
$a Siller, Michal $u Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic. Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 5, 779 00, Olomouc, Czech Republic.
700    1_
$a Tlaskalova-Hogenova, Helena $u Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20, Prague, Czech Republic.
700    1_
$a Strojil, Jan $u Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic.
700    1_
$a Anzenbacherová, Eva $u Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 775 15, Olomouc, Czech Republic. anzeneva@tunw.upol.cz. $7 stk2008428613 $4
773    0_
$w MED00001615 $t European journal of drug metabolism and pharmacokinetics $x 2107-0180 $g Roč. 42, č. 1 (2017), s. 29-36
856    41
$u https://pubmed.ncbi.nlm.nih.gov/26797809 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20171025 $b ABA008
991    __
$a 20171102103415 $b ABA008
999    __
$a ok $b bmc $g 1255459 $s 992893
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 42 $c 1 $d 29-36 $i 2107-0180 $m European journal of drug metabolism and pharmacokinetics $n Eur J Drug Metab Pharmacokinet $x MED00001615
LZP    __
$a Pubmed-20171025

Find record

Citation metrics

Archiving options