Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Considerable variations in growth hormone policy and prescription in paediatric end-stage renal disease across European countries-a report from the ESPN/ERA-EDTA registry

M. van Huis, M. Bonthuis, E. Sahpazova, F. Mencarelli, B. Spasojević, G. Reusz, A. Caldas-Afonso, A. Bjerre, S. Baiko, K. Vondrak, EA. Molchanova, G. Kolvek, N. Zaikova, M. Böhm, G. Ariceta, KJ. Jager, F. Schaefer, KJ. van Stralen, JW. Groothoff,

. 2016 ; 31 (4) : 609-19. [pub] 20150428

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17031911

BACKGROUND: Growth retardation in paediatric end-stage renal disease (ESRD) has a serious impact on adult life. It is potentially treatable with recombinant growth hormone (rGH). In this study, we aimed to quantify the variation in rGH policies and actual provided care in these patients across Europe. METHODS: Renal registry representatives of 38 European countries received a structured questionnaire on rGH policy. Cross-sectional data on height and actual use of rGH on children with ESRD aged <18 years were retrieved from the ESPN/ERA-EDTA Registry. RESULTS: In 21 (75%) of 28 responding countries, rGH is reimbursed for children with ESRD. The specific conditions for reimbursement (minimum age, maximum age and chronic kidney disease stage) vary considerably. Mean height standard deviation scores (SDS) at renal replacement therapy (RRT) [95% confidence interval (CI)] were significantly higher in countries where rGH was reimbursed -1.80 (-2.06; -1.53) compared with countries in which it was not reimbursed [-2.34 (-2.49;-2.18), P < 0.001]. Comparison of the mean height SDS at onset of RRT and final height SDS yielded similar results. Among the 13 countries for which both data on actual rGH use between 2007 and 2011 and data from the questionnaire were available, 30.1% of dialysis and 42.3% of transplanted patients had a short stature, while only 24.1 and 7.6% of those short children used rGH, respectively. CONCLUSION: Reimbursement of rGH associates with a less compromised final stature of ESRD children. In many countries with full rGH reimbursement, the actual rGH prescription in growth-retarded ESRD children is low and obviously more determined by the doctor's and patients' attitude towards rGH therapy than by financial hurdles.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17031911
003      
CZ-PrNML
005      
20171025115635.0
007      
ta
008      
171025s2016 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1093/ndt/gfv105 $2 doi
035    __
$a (PubMed)25925700
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a van Huis, M $u Department of Pediatric Nephrology, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.
245    10
$a Considerable variations in growth hormone policy and prescription in paediatric end-stage renal disease across European countries-a report from the ESPN/ERA-EDTA registry / $c M. van Huis, M. Bonthuis, E. Sahpazova, F. Mencarelli, B. Spasojević, G. Reusz, A. Caldas-Afonso, A. Bjerre, S. Baiko, K. Vondrak, EA. Molchanova, G. Kolvek, N. Zaikova, M. Böhm, G. Ariceta, KJ. Jager, F. Schaefer, KJ. van Stralen, JW. Groothoff,
520    9_
$a BACKGROUND: Growth retardation in paediatric end-stage renal disease (ESRD) has a serious impact on adult life. It is potentially treatable with recombinant growth hormone (rGH). In this study, we aimed to quantify the variation in rGH policies and actual provided care in these patients across Europe. METHODS: Renal registry representatives of 38 European countries received a structured questionnaire on rGH policy. Cross-sectional data on height and actual use of rGH on children with ESRD aged <18 years were retrieved from the ESPN/ERA-EDTA Registry. RESULTS: In 21 (75%) of 28 responding countries, rGH is reimbursed for children with ESRD. The specific conditions for reimbursement (minimum age, maximum age and chronic kidney disease stage) vary considerably. Mean height standard deviation scores (SDS) at renal replacement therapy (RRT) [95% confidence interval (CI)] were significantly higher in countries where rGH was reimbursed -1.80 (-2.06; -1.53) compared with countries in which it was not reimbursed [-2.34 (-2.49;-2.18), P < 0.001]. Comparison of the mean height SDS at onset of RRT and final height SDS yielded similar results. Among the 13 countries for which both data on actual rGH use between 2007 and 2011 and data from the questionnaire were available, 30.1% of dialysis and 42.3% of transplanted patients had a short stature, while only 24.1 and 7.6% of those short children used rGH, respectively. CONCLUSION: Reimbursement of rGH associates with a less compromised final stature of ESRD children. In many countries with full rGH reimbursement, the actual rGH prescription in growth-retarded ESRD children is low and obviously more determined by the doctor's and patients' attitude towards rGH therapy than by financial hurdles.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a tělesná výška $7 D001827
650    _2
$a dítě $7 D002648
650    _2
$a předškolní dítě $7 D002675
650    _2
$a průřezové studie $7 D003430
650    _2
$a Evropa $7 D005060
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidský růstový hormon $x terapeutické užití $7 D019382
650    _2
$a lidé $7 D006801
650    _2
$a kojenec $7 D007223
650    _2
$a novorozenec $7 D007231
650    _2
$a chronické selhání ledvin $x terapie $7 D007676
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lékařská praxe - způsoby provádění $x zákonodárství a právo $7 D010818
650    _2
$a léky na předpis $x aplikace a dávkování $7 D055553
650    _2
$a registrace $7 D012042
650    _2
$a náhrada funkce ledvin $x statistika a číselné údaje $7 D017582
650    _2
$a průzkumy a dotazníky $7 D011795
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Bonthuis, M $u ESPN/ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, Amsterdam, The Netherlands.
700    1_
$a Sahpazova, E $u University Pediatric Clinic, Skopje, FYROM.
700    1_
$a Mencarelli, F $u Nephrology and Dialysis Unit, Department of Pediatrics, Azienda Ospedaliero Universitaria Sant'Orsola-Malpighi, Bologna, Italy.
700    1_
$a Spasojević, B $u Department of Nephrology, University Children's hospital, Belgrade, Serbia.
700    1_
$a Reusz, G $u Semmelweis University Budapest, Budapest, Hungary.
700    1_
$a Caldas-Afonso, A $u Serviçio de Pediatria, Hospital de S. João, Porto, Portugal.
700    1_
$a Bjerre, A $u Department of Pediatrics, Oslo University Hospital, Rikshospitalet, Norway.
700    1_
$a Baiko, S $u 2nd Children's Hospital, Minsk, Belarus.
700    1_
$a Vondrak, K $u University Hospital Prague-Motol, Prague, Czech Republic.
700    1_
$a Molchanova, E A $u Department of Kidney Transplantation, Russian Children's Clinical Hospital, Moscow, Russia.
700    1_
$a Kolvek, G $u Paediatric Department, Faculty of Medicine, Safarik University, Kosice, Slovakia.
700    1_
$a Zaikova, N $u Research Institute for Mother and Child Health Care, Chisinau, Moldova.
700    1_
$a Böhm, M $u Department of Pediatric Nephrology, University Children's Hospital, Vienna, Austria.
700    1_
$a Ariceta, G $u Servicio de Nefrología Pediátrica y Hemodiálisis, Hospital Universitario Materno-Infantil Vall D'Hebron, Barcelona, Spain. $7 gn_A_00008423
700    1_
$a Jager, K J $u ESPN/ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, Amsterdam, The Netherlands.
700    1_
$a Schaefer, F $u Department of Paediatric Nephrology, University of Heidelberg, Center for Pediatrics and Adolescent Medicine, Heidelberg, Germany.
700    1_
$a van Stralen, K J $u ESPN/ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, Amsterdam, The Netherlands.
700    1_
$a Groothoff, J W $u Department of Pediatric Nephrology, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.
773    0_
$w MED00010288 $t Nephrology, dialysis, transplantation official publication of the European Dialysis and Transplant Association - European Renal Association $x 1460-2385 $g Roč. 31, č. 4 (2016), s. 609-19
856    41
$u https://pubmed.ncbi.nlm.nih.gov/25925700 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20171025 $b ABA008
991    __
$a 20171025115717 $b ABA008
999    __
$a ok $b bmc $g 1255504 $s 992938
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 31 $c 4 $d 609-19 $e 20150428 $i 1460-2385 $m Nephrology, dialysis, transplantation $n Nephrol Dial Transplant $x MED00010288
LZP    __
$a Pubmed-20171025

Najít záznam

Citační ukazatele

Možnosti archivace