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Film wound dressing with local anesthetic based on insoluble carboxymethycellulose matrix
Lenka Vinklárková, Ruta Masteiková, Gabriela Foltýnová, Jan Muselík, Sylvie Pavloková, Jurga Bernatonienė, David Vetchý
Jazyk angličtina Země Česko
Typ dokumentu práce podpořená grantem
- MeSH
- anestetika lokální * MeSH
- bolest farmakoterapie MeSH
- chemie farmaceutická MeSH
- lékové formy MeSH
- lidokain MeSH
- lokální anestezie MeSH
- nosiče léků chemická syntéza chemie MeSH
- obvazy * MeSH
- povrchové vlastnosti MeSH
- rány a poranění terapie MeSH
- sodná sůl karboxymethylcelulosy * chemie MeSH
- systémy cílené aplikace léků MeSH
- techniky in vitro MeSH
- uvolňování léčiv MeSH
- Publikační typ
- práce podpořená grantem MeSH
The aim of the presented research was to formulate, prepare and evaluate novel film wound dressings containing lidocaine hydrochloride. The conversion of partially substituted fibrous sodium carboxymethylcellulose (CMC) to an acidic form of CMC enabled the formation of an insoluble matrix which consequently provided the prepared films with excellent handling properties in their wet state. The drug concentration which was incorporated into an external layer of the film was 5 mg/cm2. The films demonstrated satisfactory mass and drug content uniformity as well as an acidic surface pH advantageous for wound application. An in vitro drug release test proved that the insoluble CMC matrix served as a reliable carrier without slowing down the release of lidocaine hydrochloride − more than 90% of the drug was released during the first 15 min, indicating a quick rate of anesthetic action. The prepared films could be potential wound dressings for comfortable and efficient topical anesthesia before/after procedures on the wound.
Faculty of Pharmacy Department of Pharmaceutics Brno Czech Republic
Citace poskytuje Crossref.org
Literatura
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- $a Film wound dressing with local anesthetic based on insoluble carboxymethycellulose matrix / $c Lenka Vinklárková, Ruta Masteiková, Gabriela Foltýnová, Jan Muselík, Sylvie Pavloková, Jurga Bernatonienė, David Vetchý
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- $a The aim of the presented research was to formulate, prepare and evaluate novel film wound dressings containing lidocaine hydrochloride. The conversion of partially substituted fibrous sodium carboxymethylcellulose (CMC) to an acidic form of CMC enabled the formation of an insoluble matrix which consequently provided the prepared films with excellent handling properties in their wet state. The drug concentration which was incorporated into an external layer of the film was 5 mg/cm2. The films demonstrated satisfactory mass and drug content uniformity as well as an acidic surface pH advantageous for wound application. An in vitro drug release test proved that the insoluble CMC matrix served as a reliable carrier without slowing down the release of lidocaine hydrochloride − more than 90% of the drug was released during the first 15 min, indicating a quick rate of anesthetic action. The prepared films could be potential wound dressings for comfortable and efficient topical anesthesia before/after procedures on the wound.
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