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The Role of Oxysterols in Human Cancer
A. Kloudova, FP. Guengerich, P. Soucek,
Language English Country United States
Document type Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural
- MeSH
- Cholesterol metabolism MeSH
- Hydroxycholesterols pharmacology MeSH
- Humans MeSH
- Metabolic Networks and Pathways drug effects MeSH
- Lipid Metabolism drug effects MeSH
- Neoplasms etiology metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Research Support, N.I.H., Extramural MeSH
Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested in the diet. By modulating the activity of many proteins [e.g., liver X receptors (LXRs), oxysterol-binding proteins (OSBPs), some ATP-binding cassette (ABC) transporters], oxysterols can affect many cellular functions and influence various physiological processes (e.g., cholesterol metabolism, membrane fluidity regulation, intracellular signaling pathways). Therefore, the role of oxysterols is also important in pathological conditions (e.g., atherosclerosis, diabetes mellitus type 2, neurodegenerative disorders). Finally, current evidence suggests that oxysterols play a role in malignancies such as breast, prostate, colon, and bile duct cancer. This review summarizes the physiological importance of oxysterols in the human body with a special emphasis on their roles in various tumors.
3rd Faculty of Medicine Charles University Prague 100 00 Czech Republic
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen 323 00 Czech Republic
Department of Biochemistry Vanderbilt University School of Medicine Nashville TN 37232 USA
Department of Toxicogenomics National Institute of Public Health Prague 100 42 Czech Republic
References provided by Crossref.org
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